FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965221402> ?p ?o ?g. }

• W1965221402 endingPage "1081" @default.
• W1965221402 startingPage "1067" @default.
• W1965221402 abstract "In mammals, the unique midkine (mdk) gene encodes a secreted heparin-binding growth factor with neurotrophic activity. Here, we show the presence of two functional mdk genes named mdka and mdkb in zebrafish and rainbow trout. Both midkine proteins are clearly different from the related pleiotrophin, which was also identified in zebrafish and other fishes. Zebrafish mdka and mdkb genes map to linkage groups LG7 and LG25, respectively, both presenting synteny to human chromosome 11, in which the unique human ortholog mdk is located. At least four other genes unique in mammals are also present as duplicates on LG7 and LG25. Phylogenetic and divergence analyses suggested that LG7/LG25 paralogs including mdka and mdkb have been formed at approximately the same time, early during the evolution of the fish lineage. Hence, zebrafish and rainbow trout mdka and mdkb might have been generated by an ancient block duplication, and might be remnants of the proposed fish-specific whole-genome duplication. In contrast to the ubiquitous expression of their mammalian counterpart, zebrafish mdka and mdkb are expressed in spatially restricted, mostly nonoverlapping patterns during embryonic development and strongly in distinct domains in the adult brain. Ectopic ubiquitous expression of both mdk genes in early zebrafish embryos caused completely distinct effects on neural crest and floorplate development. These data indicate that mdka and mdkb underwent functional divergence after duplication. This provides an outstanding model to analyze the molecular mechanisms that lead to differences in pathways regulating the formation of homologous embryonic structures in different vertebrates." @default.
• W1965221402 created "2016-06-24" @default.
• W1965221402 creator A5029643939 @default.
• W1965221402 creator A5031215616 @default.
• W1965221402 creator A5053102600 @default.
• W1965221402 creator A5078748028 @default.
• W1965221402 creator A5083609593 @default.
• W1965221402 date "2003-05-12" @default.
• W1965221402 modified "2023-10-02" @default.
• W1965221402 title "Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-Specific Gene Duplication" @default.
• W1965221402 cites W1495565929 @default.
• W1965221402 cites W1498740969 @default.
• W1965221402 cites W151207798 @default.
• W1965221402 cites W1520098011 @default.
• W1965221402 cites W1545009729 @default.
• W1965221402 cites W1574089736 @default.
• W1965221402 cites W1634376377 @default.
• W1965221402 cites W1667206495 @default.
• W1965221402 cites W1727814965 @default.
• W1965221402 cites W1838303488 @default.
• W1965221402 cites W1929503316 @default.
• W1965221402 cites W1970835368 @default.
• W1965221402 cites W1971012459 @default.
• W1965221402 cites W1974723367 @default.
• W1965221402 cites W1988547053 @default.
• W1965221402 cites W1992297402 @default.
• W1965221402 cites W2000932006 @default.
• W1965221402 cites W2008692424 @default.
• W1965221402 cites W2010673355 @default.
• W1965221402 cites W2015633789 @default.
• W1965221402 cites W2017354392 @default.
• W1965221402 cites W2021128909 @default.
• W1965221402 cites W2021352779 @default.
• W1965221402 cites W2024018378 @default.
• W1965221402 cites W2032040395 @default.
• W1965221402 cites W2034477126 @default.
• W1965221402 cites W2035847060 @default.
• W1965221402 cites W2042080445 @default.
• W1965221402 cites W2043359206 @default.
• W1965221402 cites W2049642777 @default.
• W1965221402 cites W2050538166 @default.
• W1965221402 cites W2055238787 @default.
• W1965221402 cites W2056105561 @default.
• W1965221402 cites W2059453272 @default.
• W1965221402 cites W2066187005 @default.
• W1965221402 cites W2067031548 @default.
• W1965221402 cites W2068918006 @default.
• W1965221402 cites W2074274229 @default.
• W1965221402 cites W2077597259 @default.
• W1965221402 cites W2081235375 @default.
• W1965221402 cites W2083296412 @default.
• W1965221402 cites W2085109269 @default.
• W1965221402 cites W2088411049 @default.
• W1965221402 cites W2090513735 @default.
• W1965221402 cites W2097382368 @default.
• W1965221402 cites W2097706568 @default.
• W1965221402 cites W2100855116 @default.
• W1965221402 cites W2110721168 @default.
• W1965221402 cites W2116335962 @default.
• W1965221402 cites W2116451502 @default.
• W1965221402 cites W2117066685 @default.
• W1965221402 cites W2119469219 @default.
• W1965221402 cites W2120960764 @default.
• W1965221402 cites W2122911447 @default.
• W1965221402 cites W2123302656 @default.
• W1965221402 cites W2125349610 @default.
• W1965221402 cites W2128650008 @default.
• W1965221402 cites W2129873761 @default.
• W1965221402 cites W2131412639 @default.
• W1965221402 cites W2137259658 @default.
• W1965221402 cites W2137845412 @default.
• W1965221402 cites W2143920612 @default.
• W1965221402 cites W2149278002 @default.
• W1965221402 cites W2152075687 @default.
• W1965221402 cites W2158071345 @default.
• W1965221402 cites W2161193684 @default.
• W1965221402 cites W2162262697 @default.
• W1965221402 cites W2164997158 @default.
• W1965221402 cites W2172286707 @default.
• W1965221402 cites W2208941368 @default.
• W1965221402 cites W2418182246 @default.
• W1965221402 cites W2559313591 @default.
• W1965221402 cites W4232087855 @default.
• W1965221402 cites W4242530862 @default.
• W1965221402 cites W4256020451 @default.
• W1965221402 cites W2409682577 @default.
• W1965221402 doi "https://doi.org/10.1101/gr.1097503" @default.
• W1965221402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/403662" @default.
• W1965221402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12743018" @default.
• W1965221402 hasPublicationYear "2003" @default.
• W1965221402 type Work @default.
• W1965221402 sameAs 1965221402 @default.
• W1965221402 citedByCount "66" @default.
• W1965221402 countsByYear W19652214022012 @default.
• W1965221402 countsByYear W19652214022013 @default.
• W1965221402 countsByYear W19652214022014 @default.
• W1965221402 countsByYear W19652214022015 @default.
• W1965221402 countsByYear W19652214022018 @default.

• next