FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965237750> ?p ?o ?g. }

• W1965237750 endingPage "761" @default.
• W1965237750 startingPage "752" @default.
• W1965237750 abstract "Abstract The majority of tumor‐associated antigens are aberrantly expressed or overexpressed normal gene products. Therefore, mechanisms responsible for self tolerance dampen immune responses against these antigens. To evaluate the effect that tolerance has on the immune responses against tumor antigens, we characterized the CD8 + T cell responses in neu mice. T cell responses against theA2.1/neu p369–377 and p773–782 peptides were evaluated in neu mice that were crossed with A2.1/Kb transgenic mice (A2×neu). Tetramer binding and cytotoxic activity demonstrate that, compared to CTL from A2.1/Kb×FVB wild‐type mice (A2×FVB), CD8 + T cells from A2×neu mice were of lower avidity for the peptides. Despite the fact that A2×neu mice are tolerant, multipleimmunizations with DC pulsed with the p369–377 or p773–782 peptides in the presence of IL‐2 retarded tumor growth in A2×neu mice, and immunizations in combination with the anti‐OX40 mAb further enhanced the antitumor response. Taken together, these data indicate that low‐avidity T cells for neu antigens persisting in A2×neu mice have the capacity to develop antitumor responses as long as they are provided with efficient costimulation. These results underscore the potential role of low‐avidity T cells in antitumor immunity and may offer an important component for vaccination immunotherapies." @default.
• W1965237750 created "2016-06-24" @default.
• W1965237750 creator A5027377475 @default.
• W1965237750 creator A5045577060 @default.
• W1965237750 creator A5081929966 @default.
• W1965237750 date "2004-02-25" @default.
• W1965237750 modified "2023-10-16" @default.
• W1965237750 title "The CD8⁺T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity" @default.
• W1965237750 cites W1509401982 @default.
• W1965237750 cites W1599973887 @default.
• W1965237750 cites W1610255617 @default.
• W1965237750 cites W1705182747 @default.
• W1965237750 cites W1963631321 @default.
• W1965237750 cites W1982093899 @default.
• W1965237750 cites W2001640241 @default.
• W1965237750 cites W2006987944 @default.
• W1965237750 cites W2008564146 @default.
• W1965237750 cites W2008875850 @default.
• W1965237750 cites W2038773736 @default.
• W1965237750 cites W2058864999 @default.
• W1965237750 cites W2077927974 @default.
• W1965237750 cites W2078760290 @default.
• W1965237750 cites W2079816467 @default.
• W1965237750 cites W2087843772 @default.
• W1965237750 cites W2088890805 @default.
• W1965237750 cites W2097009175 @default.
• W1965237750 cites W2097179308 @default.
• W1965237750 cites W2103767560 @default.
• W1965237750 cites W2141935247 @default.
• W1965237750 cites W2156253561 @default.
• W1965237750 cites W2157822148 @default.
• W1965237750 cites W2164339006 @default.
• W1965237750 cites W2170584525 @default.
• W1965237750 cites W2326276411 @default.
• W1965237750 doi "https://doi.org/10.1002/eji.200324427" @default.
• W1965237750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14991605" @default.
• W1965237750 hasPublicationYear "2004" @default.
• W1965237750 type Work @default.
• W1965237750 sameAs 1965237750 @default.
• W1965237750 citedByCount "69" @default.
• W1965237750 countsByYear W19652377502012 @default.
• W1965237750 countsByYear W19652377502013 @default.
• W1965237750 countsByYear W19652377502015 @default.
• W1965237750 countsByYear W19652377502017 @default.
• W1965237750 countsByYear W19652377502018 @default.
• W1965237750 countsByYear W19652377502020 @default.
• W1965237750 crossrefType "journal-article" @default.
• W1965237750 hasAuthorship W1965237750A5027377475 @default.
• W1965237750 hasAuthorship W1965237750A5045577060 @default.
• W1965237750 hasAuthorship W1965237750A5081929966 @default.
• W1965237750 hasConcept C102230213 @default.
• W1965237750 hasConcept C104317684 @default.
• W1965237750 hasConcept C141035611 @default.
• W1965237750 hasConcept C147483822 @default.
• W1965237750 hasConcept C147969180 @default.
• W1965237750 hasConcept C153911025 @default.
• W1965237750 hasConcept C154317977 @default.
• W1965237750 hasConcept C167672396 @default.
• W1965237750 hasConcept C179223381 @default.
• W1965237750 hasConcept C202751555 @default.
• W1965237750 hasConcept C203014093 @default.
• W1965237750 hasConcept C2776090121 @default.
• W1965237750 hasConcept C55493867 @default.
• W1965237750 hasConcept C86803240 @default.
• W1965237750 hasConcept C8891405 @default.
• W1965237750 hasConceptScore W1965237750C102230213 @default.
• W1965237750 hasConceptScore W1965237750C104317684 @default.
• W1965237750 hasConceptScore W1965237750C141035611 @default.
• W1965237750 hasConceptScore W1965237750C147483822 @default.
• W1965237750 hasConceptScore W1965237750C147969180 @default.
• W1965237750 hasConceptScore W1965237750C153911025 @default.
• W1965237750 hasConceptScore W1965237750C154317977 @default.
• W1965237750 hasConceptScore W1965237750C167672396 @default.
• W1965237750 hasConceptScore W1965237750C179223381 @default.
• W1965237750 hasConceptScore W1965237750C202751555 @default.
• W1965237750 hasConceptScore W1965237750C203014093 @default.
• W1965237750 hasConceptScore W1965237750C2776090121 @default.
• W1965237750 hasConceptScore W1965237750C55493867 @default.
• W1965237750 hasConceptScore W1965237750C86803240 @default.
• W1965237750 hasConceptScore W1965237750C8891405 @default.
• W1965237750 hasIssue "3" @default.
• W1965237750 hasLocation W19652377501 @default.
• W1965237750 hasLocation W19652377502 @default.
• W1965237750 hasOpenAccess W1965237750 @default.
• W1965237750 hasPrimaryLocation W19652377501 @default.
• W1965237750 hasRelatedWork W1479760379 @default.
• W1965237750 hasRelatedWork W1488522044 @default.
• W1965237750 hasRelatedWork W1501233675 @default.
• W1965237750 hasRelatedWork W1526773517 @default.
• W1965237750 hasRelatedWork W1565230971 @default.
• W1965237750 hasRelatedWork W1643293176 @default.
• W1965237750 hasRelatedWork W2023919916 @default.
• W1965237750 hasRelatedWork W2030704727 @default.
• W1965237750 hasRelatedWork W2085055743 @default.
• W1965237750 hasRelatedWork W2318603631 @default.
• W1965237750 hasVolume "34" @default.
• W1965237750 isParatext "false" @default.
• W1965237750 isRetracted "false" @default.

• next