FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965248045> ?p ?o ?g. }

• W1965248045 endingPage "1038" @default.
• W1965248045 startingPage "1031" @default.
• W1965248045 abstract "Endoplasmic reticulum (ER)-associated degradation (ERAD) of unassembled T-cell receptor alpha-chain (TCRalpha) is reliant on the presence of two basic residues in the transmembrane (TM) segment of TCRalpha. The precise role of these residues in ER quality control is unclear. Here, we show that a TCRalpha mutant lacking these intramembrane charged residues has a tendency to form homooligomers through an interchain disulfide bond that involves a specific pair of cysteine residues. Covalent oligomerization of TCRalpha appears to stabilize it at the ER membrane. The presence of a single lysine residue at specific positions within the TCRalpha TM domain abolishes its oligomerization and causes its rapid degradation. Conversely, when TCRalpha oligomerization is induced by a bivalent compound, the degradation of TCRalpha is inhibited. Together, these results suggest that the intramembrane charged residues in TCRalpha do not function as a signal for substrate recognition in ERAD. Instead, their primary role is to reduce TCRalpha oligomerization, maintaining it in a retrotranslocation-competent state. Our results also suggest that the ERAD machinery is inefficient when coping with oligomerized substrates, indicating a requirement for chaperone-mediated protein disassembly in the ER lumen prior to retrotranslocation." @default.
• W1965248045 created "2016-06-24" @default.
• W1965248045 creator A5020782532 @default.
• W1965248045 creator A5044766614 @default.
• W1965248045 creator A5046551911 @default.
• W1965248045 creator A5058092999 @default.
• W1965248045 date "2010-04-01" @default.
• W1965248045 modified "2023-10-18" @default.
• W1965248045 title "Role of intramembrane charged residues in the quality control of unassembled T-cell receptor α-chains at the endoplasmic reticulum" @default.
• W1965248045 cites W1510774549 @default.
• W1965248045 cites W1592548488 @default.
• W1965248045 cites W168389016 @default.
• W1965248045 cites W1965588273 @default.
• W1965248045 cites W1976981613 @default.
• W1965248045 cites W1981551685 @default.
• W1965248045 cites W1984347348 @default.
• W1965248045 cites W2000806214 @default.
• W1965248045 cites W2004468088 @default.
• W1965248045 cites W2005763639 @default.
• W1965248045 cites W2007422965 @default.
• W1965248045 cites W2009664225 @default.
• W1965248045 cites W2011655817 @default.
• W1965248045 cites W2021773042 @default.
• W1965248045 cites W2031644342 @default.
• W1965248045 cites W2033088972 @default.
• W1965248045 cites W2037926081 @default.
• W1965248045 cites W2046933512 @default.
• W1965248045 cites W2048481017 @default.
• W1965248045 cites W2049127225 @default.
• W1965248045 cites W2049656093 @default.
• W1965248045 cites W2050356515 @default.
• W1965248045 cites W2050871949 @default.
• W1965248045 cites W2051248831 @default.
• W1965248045 cites W2051881845 @default.
• W1965248045 cites W2064609154 @default.
• W1965248045 cites W2065278356 @default.
• W1965248045 cites W2066516932 @default.
• W1965248045 cites W2068306128 @default.
• W1965248045 cites W2081104776 @default.
• W1965248045 cites W2114366341 @default.
• W1965248045 cites W2135450099 @default.
• W1965248045 cites W2137390014 @default.
• W1965248045 cites W2141109151 @default.
• W1965248045 cites W2141284487 @default.
• W1965248045 cites W2146969978 @default.
• W1965248045 cites W2148304657 @default.
• W1965248045 cites W2152351845 @default.
• W1965248045 cites W2155946179 @default.
• W1965248045 cites W2156617634 @default.
• W1965248045 cites W2158959097 @default.
• W1965248045 cites W2170117828 @default.
• W1965248045 cites W2170220756 @default.
• W1965248045 cites W2171862076 @default.
• W1965248045 doi "https://doi.org/10.1242/jcs.059758" @default.
• W1965248045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844315" @default.
• W1965248045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20332119" @default.
• W1965248045 hasPublicationYear "2010" @default.
• W1965248045 type Work @default.
• W1965248045 sameAs 1965248045 @default.
• W1965248045 citedByCount "25" @default.
• W1965248045 countsByYear W19652480452012 @default.
• W1965248045 countsByYear W19652480452013 @default.
• W1965248045 countsByYear W19652480452014 @default.
• W1965248045 countsByYear W19652480452016 @default.
• W1965248045 countsByYear W19652480452018 @default.
• W1965248045 countsByYear W19652480452019 @default.
• W1965248045 countsByYear W19652480452020 @default.
• W1965248045 countsByYear W19652480452022 @default.
• W1965248045 crossrefType "journal-article" @default.
• W1965248045 hasAuthorship W1965248045A5020782532 @default.
• W1965248045 hasAuthorship W1965248045A5044766614 @default.
• W1965248045 hasAuthorship W1965248045A5046551911 @default.
• W1965248045 hasAuthorship W1965248045A5058092999 @default.
• W1965248045 hasBestOaLocation W19652480451 @default.
• W1965248045 hasConcept C139447449 @default.
• W1965248045 hasConcept C142724271 @default.
• W1965248045 hasConcept C158617107 @default.
• W1965248045 hasConcept C158619295 @default.
• W1965248045 hasConcept C2775962898 @default.
• W1965248045 hasConcept C71924100 @default.
• W1965248045 hasConcept C86803240 @default.
• W1965248045 hasConcept C95444343 @default.
• W1965248045 hasConceptScore W1965248045C139447449 @default.
• W1965248045 hasConceptScore W1965248045C142724271 @default.
• W1965248045 hasConceptScore W1965248045C158617107 @default.
• W1965248045 hasConceptScore W1965248045C158619295 @default.
• W1965248045 hasConceptScore W1965248045C2775962898 @default.
• W1965248045 hasConceptScore W1965248045C71924100 @default.
• W1965248045 hasConceptScore W1965248045C86803240 @default.
• W1965248045 hasConceptScore W1965248045C95444343 @default.
• W1965248045 hasIssue "7" @default.
• W1965248045 hasLocation W19652480451 @default.
• W1965248045 hasLocation W19652480452 @default.
• W1965248045 hasLocation W19652480453 @default.
• W1965248045 hasLocation W19652480454 @default.
• W1965248045 hasOpenAccess W1965248045 @default.
• W1965248045 hasPrimaryLocation W19652480451 @default.
• W1965248045 hasRelatedWork W2041749209 @default.

• next