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- W1965269715 abstract "A highly effective procedure is reported to synthesize 1,2-aminoalcohols by regio- and chemo-selective ammonolysis of mono-substituted epoxides. Additive- and concentration-effects were studied, revealing that (1) methanesulfonic acid is most effective among the additives tested and (2) formation of bis-adducts is practically eliminated at [C] ⩽ 40 mM. The optimum condition thus identified was successfully applied to the final step of the synthesis of potent anti-tumor compound E7389." @default.
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- W1965269715 date "2007-12-01" @default.
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- W1965269715 title "Effective procedure for selective ammonolysis of monosubstituted oxiranes: application to E7389 synthesis" @default.
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- W1965269715 doi "https://doi.org/10.1016/j.tetlet.2007.10.116" @default.
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