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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965283399> ?p ?o ?g. }

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• W1965283399 abstract "Development of atherosclerosis in diabetes patients is thought to be associated with high D-glucose-induced changes in vascular cell proliferation. This study was designed to investigate the intracellular mechanisms of altered proliferation in porcine aortic endothelial and smooth muscle cells under high D-glucose conditions. Two different technical approaches were used for determination of cell proliferation, a cell counting procedure and bromodeoxyuridine incorporation. D-Glucose diminished endothelial cell proliferation (30.3%) and increased smooth muscle cell proliferation (143%) in a dose-dependent manner. Neither D-mannitol, sucrose nor L-glucose mimicked the effect of D-glucose. Inhibition of D-glucose uptake into vascular cells by cytochalasin B prevented the effect of high D-glucose on cell proliferation. The aldose-reductase inhibitors, sorbinil and zopolrestat, little affected high D-glucose-attenuated endothelial cell proliferation, while the enhanced proliferation of smooth muscle cells was prevented by aldose-reductase inhibitors. Elevation of cellular glutathione levels yielded protection of both cell types from high D-glucose-mediated changes in cell proliferation, suggesting that high D-glucose may act via generation of oxidative species. Finally, aminoguanidine was shown to constitute a very potent inhibitor of D-glucose-induced dysfunction in vascular cell proliferation. These data suggest that high D-glucose-induced changes in cell proliferation of endothelial and smooth muscle cells are related to specific D-glucose uptake rather than hyperosmolality. Aldose-reductase seems to be mainly involved in the effect of high D-glucose only on smooth muscle cell proliferation, while in endothelial cells there is (are) other factor(s) in addition to the sorbitol pathway involved in high D-glucose-induced changes in cell proliferation." @default.
• W1965283399 created "2016-06-24" @default.
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• W1965283399 date "1995-12-01" @default.
• W1965283399 modified "2023-10-14" @default.
• W1965283399 title "Intracellular mechanism of highd-glucose-induced modulation of vascular cell proliferation" @default.
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• W1965283399 doi "https://doi.org/10.1016/0014-2999(95)00534-x" @default.
• W1965283399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8788435" @default.
• W1965283399 hasPublicationYear "1995" @default.
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