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- W1965291256 abstract "Decreased expression of diacylglycerol kinase (DGK) δ in skeletal muscles is closely related to the pathogenesis of type 2 diabetes. However, the regulation of DGKδ expression is not well understood. In this study, we found that myristic acid (14:0) significantly increased DGKδ2 protein expression in a dose-dependent manner (EC(50) = 0.16 mM) in mouse C2C12 myotubes. In contrast, oleic [18:1(n-9)], eicosenoic [20:1(n-9)] and erucic [22:1(n-9)] acids markedly decreased DGKδ2 expression. Myristic acid slowly enhanced DGKδ2 expression at the transcription level. Therefore, DGKδ2 expression is positively regulated by the relatively short-chain saturated fatty acid myristic acid but attenuated by n-9 monounsaturated fatty acids." @default.
- W1965291256 created "2016-06-24" @default.
- W1965291256 creator A5016441483 @default.
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- W1965291256 date "2014-05-23" @default.
- W1965291256 modified "2023-09-30" @default.
- W1965291256 title "Regulation of Diacylglycerol Kinase δ2 Expression in C2C12 Skeletal Muscle Cells by Free Fatty Acids" @default.
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- W1965291256 doi "https://doi.org/10.1007/s11745-014-3912-9" @default.
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