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- W1965291498 abstract "Th1 cells, which express IL-18R, produce IFN-γ in response to Ag and IL-2 and increase further production of IFN-γ upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 and IL-13), GM-CSF and chemokines (RANTES, MIP-1α). Human Th1 cells also produce IFN-γ and IL-13 in response to anti-CD3 and IL-18. Recently, we demonstrated Th1 cells induce intrinsic type atopic asthma and dermatitis by production of Th1- and Th2-cytokines and chemokines. Here, we review the pathological roles of Th1 cells, stimulated with Ag and IL-18 in vivo, in the pathogenesis of allergic disorders by production of Th1 and Th2 cytokines and chemokines. Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as “super Th1 cells”." @default.
- W1965291498 created "2016-06-24" @default.
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- W1965291498 date "2010-01-01" @default.
- W1965291498 modified "2023-09-30" @default.
- W1965291498 title "Importance of IL-18-induced Super Th1 Cells for the Development of Allergic Inflammation" @default.
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- W1965291498 doi "https://doi.org/10.2332/allergolint.10-rai-0208" @default.
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