Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965302562> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1965302562 endingPage "269" @default.
- W1965302562 startingPage "262" @default.
- W1965302562 abstract "A sensitive ELISA assay for quantifying erythrocyte (E) bound C3 fragments was developed. The assay employs a double-antibody sandwich technique, using polyclonal anti-C3d or anti-C3c antibodies to quantify C3 fragments, expressing C3d and/or C3c epitopes in washed, detergent-solubilized E. The assay detected 50-120 molecules of C3d per E in healthy individuals. Antigens reacting with anti-C3c antibodies were also detected on E from normal individuals, but the density of C3c-epitopes was 0.9-2.4 times lower than that of C3d-epitopes. In 2 patients with congenital factor I deficiency significantly increased density of E-bound C3c- as well as C3d-antigen was observed. Plasma infusion in one of the patients induced a loss of E-bound C3c-antigens, indicating cleavage of E-bound C3b to iC3b and further to C3c and E-bound C3d. Loss of C3c-antigens also occurred following in vitro treatment with normal human serum of E from one of the patients. Two thirds of 22 patients with systemic lupus erythematosus (SLE) and of 18 patients with rheumatoid arthritis had significantly increased density of E-bound C3d, the highest density being 490 C3d molecules/E in an SLE patient. The density of E-bound C3d correlated with the plasma-C3d concentration, indicating that the coating of E with C3d reflects the degree of complement activation." @default.
- W1965302562 created "2016-06-24" @default.
- W1965302562 creator A5002961808 @default.
- W1965302562 creator A5005855404 @default.
- W1965302562 creator A5007083286 @default.
- W1965302562 creator A5020558434 @default.
- W1965302562 creator A5042231472 @default.
- W1965302562 creator A5042259994 @default.
- W1965302562 date "1989-05-01" @default.
- W1965302562 modified "2023-10-16" @default.
- W1965302562 title "Quantification by ELISA of Erythrocyte-Bound C3 Fragments Expressing C3d and/or C3c Epitopes in Patients with Factor I Deficiency and with Autoimmune Diseases" @default.
- W1965302562 cites W1253835855 @default.
- W1965302562 cites W1457830441 @default.
- W1965302562 cites W1462658072 @default.
- W1965302562 cites W1526898493 @default.
- W1965302562 cites W1528867643 @default.
- W1965302562 cites W1558437093 @default.
- W1965302562 cites W1578980478 @default.
- W1965302562 cites W1905838633 @default.
- W1965302562 cites W1964281843 @default.
- W1965302562 cites W1966431729 @default.
- W1965302562 cites W1984703907 @default.
- W1965302562 cites W2000680139 @default.
- W1965302562 cites W2002607976 @default.
- W1965302562 cites W2014932151 @default.
- W1965302562 cites W2020469064 @default.
- W1965302562 cites W2021702211 @default.
- W1965302562 cites W2031374319 @default.
- W1965302562 cites W2043773630 @default.
- W1965302562 cites W2074941320 @default.
- W1965302562 cites W2075560866 @default.
- W1965302562 cites W2075659518 @default.
- W1965302562 cites W2078933926 @default.
- W1965302562 cites W2166708018 @default.
- W1965302562 cites W2171118517 @default.
- W1965302562 cites W2418181439 @default.
- W1965302562 cites W345313747 @default.
- W1965302562 cites W4238708053 @default.
- W1965302562 cites W4246240125 @default.
- W1965302562 cites W4293247451 @default.
- W1965302562 doi "https://doi.org/10.1111/j.1423-0410.1989.tb02039.x" @default.
- W1965302562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2474900" @default.
- W1965302562 hasPublicationYear "1989" @default.
- W1965302562 type Work @default.
- W1965302562 sameAs 1965302562 @default.
- W1965302562 citedByCount "11" @default.
- W1965302562 crossrefType "journal-article" @default.
- W1965302562 hasAuthorship W1965302562A5002961808 @default.
- W1965302562 hasAuthorship W1965302562A5005855404 @default.
- W1965302562 hasAuthorship W1965302562A5007083286 @default.
- W1965302562 hasAuthorship W1965302562A5020558434 @default.
- W1965302562 hasAuthorship W1965302562A5042231472 @default.
- W1965302562 hasAuthorship W1965302562A5042259994 @default.
- W1965302562 hasConcept C147483822 @default.
- W1965302562 hasConcept C153911025 @default.
- W1965302562 hasConcept C159654299 @default.
- W1965302562 hasConcept C185592680 @default.
- W1965302562 hasConcept C195616568 @default.
- W1965302562 hasConcept C203014093 @default.
- W1965302562 hasConcept C86803240 @default.
- W1965302562 hasConcept C956191 @default.
- W1965302562 hasConceptScore W1965302562C147483822 @default.
- W1965302562 hasConceptScore W1965302562C153911025 @default.
- W1965302562 hasConceptScore W1965302562C159654299 @default.
- W1965302562 hasConceptScore W1965302562C185592680 @default.
- W1965302562 hasConceptScore W1965302562C195616568 @default.
- W1965302562 hasConceptScore W1965302562C203014093 @default.
- W1965302562 hasConceptScore W1965302562C86803240 @default.
- W1965302562 hasConceptScore W1965302562C956191 @default.
- W1965302562 hasIssue "4" @default.
- W1965302562 hasLocation W19653025621 @default.
- W1965302562 hasLocation W19653025622 @default.
- W1965302562 hasOpenAccess W1965302562 @default.
- W1965302562 hasPrimaryLocation W19653025621 @default.
- W1965302562 hasRelatedWork W1975648827 @default.
- W1965302562 hasRelatedWork W1977052700 @default.
- W1965302562 hasRelatedWork W1980985575 @default.
- W1965302562 hasRelatedWork W1983657734 @default.
- W1965302562 hasRelatedWork W2056973121 @default.
- W1965302562 hasRelatedWork W2386118910 @default.
- W1965302562 hasRelatedWork W3138251214 @default.
- W1965302562 hasRelatedWork W3179259355 @default.
- W1965302562 hasRelatedWork W4239344034 @default.
- W1965302562 hasRelatedWork W4241395440 @default.
- W1965302562 hasVolume "56" @default.
- W1965302562 isParatext "false" @default.
- W1965302562 isRetracted "false" @default.
- W1965302562 magId "1965302562" @default.
- W1965302562 workType "article" @default.