FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965304265> ?p ?o ?g. }

• W1965304265 endingPage "41" @default.
• W1965304265 startingPage "3735" @default.
• W1965304265 abstract "Lymphokine-activated killer (LAK) cells are generated in vitro by the incubation of normal murine splenocytes in interleukin 2. We have shown previously that the systemic injection of LAK cells in conjunction with recombinant interleukin 2 can reduce the number of established pulmonary metastases in mice. In an attempt to study this approach in the treatment of hepatic metastases, we developed a technique for the induction of hepatic metastases in mice based on the intrasplenic injection of tumor cells and have tested the effects of LAK cells and recombinant interleukin 2 produced in Escherichia coli (RIL-2) therapy on these metastases. Treatment with LAK cells alone in 14 consecutive experiments rarely produced significant reduction in metastases over control (mean percentage reduction, 12%). Therapy with RIL-2 alone produced a dose-dependent reduction in the number of liver metastases. In 20 consecutive experiments when RIL-2 was administered i.p. three times a day at doses varying from 1,000 to 5,000, 10,000 to 15,000, and 25,000 units, a statistically significant (P less than 0.05) reduction in liver metastases was seen in 2 of 12, 2 of 4, and 8 of 12 determinations, respectively (percentage reduction, 0 to 97; mean, 42%). At doses greater than 25,000 units, the reduction in metastases was highly reproducible (percentage reduction, 66 to 95; mean, 83%) and was statistically significant in 14 of 14 determinations. When LAK cells were given i.v. in addition to RIL-2 administration in 16 consecutive experiments, the percentage reduction in liver metastases was markedly increased over that seen with RIL-2 alone (mean percentage reduction, 77% at doses of 5,000 to 25,000 units of RIL-2 and mean reduction, 97% for doses greater than 25,000 units of RIL-2). At doses of 5,000, 10,000, 25,000, and greater than 25,000 units of RIL-2 plus LAK cells, significant reduction of liver metastases (P less than 0.05) was achieved in 3 of 7, 2 of 2, 8 of 8, and 6 of 6 determinations, respectively. When animals were given fresh splenocytes or splenocytes cultured in complete medium without RIL-2 instead of LAK cells, no reduction in liver metastases was seen except for that attributable to the administration of RIL-2 alone. Sublethal total body irradiation of the mice prior to therapy abrogated the therapeutic effects of RIL-2, but the effects of treatment with LAK cells plus RIL-2 were maintained. Thus, treatment with RIL-2 alone or in combination with LAK cells is effective in reducing the number of established hepatic micrometastases in a murine model.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W1965304265 created "2016-06-24" @default.
• W1965304265 creator A5033871994 @default.
• W1965304265 creator A5072133376 @default.
• W1965304265 date "1985-08-01" @default.
• W1965304265 modified "2023-10-16" @default.
• W1965304265 title "Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2." @default.
• W1965304265 cites W1501496773 @default.
• W1965304265 cites W1506157243 @default.
• W1965304265 cites W1561387023 @default.
• W1965304265 cites W1565950166 @default.
• W1965304265 cites W1591093768 @default.
• W1965304265 cites W1783973309 @default.
• W1965304265 cites W1893785002 @default.
• W1965304265 cites W1965406139 @default.
• W1965304265 cites W2036275492 @default.
• W1965304265 cites W2037339580 @default.
• W1965304265 cites W2040538980 @default.
• W1965304265 cites W2051962533 @default.
• W1965304265 cites W2060931004 @default.
• W1965304265 cites W2102251060 @default.
• W1965304265 cites W2103767468 @default.
• W1965304265 cites W2130537353 @default.
• W1965304265 cites W2143594378 @default.
• W1965304265 cites W2288344645 @default.
• W1965304265 cites W2420056077 @default.
• W1965304265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3893689" @default.
• W1965304265 hasPublicationYear "1985" @default.
• W1965304265 type Work @default.
• W1965304265 sameAs 1965304265 @default.
• W1965304265 citedByCount "183" @default.
• W1965304265 countsByYear W19653042652012 @default.
• W1965304265 countsByYear W19653042652013 @default.
• W1965304265 countsByYear W19653042652014 @default.
• W1965304265 countsByYear W19653042652016 @default.
• W1965304265 countsByYear W19653042652018 @default.
• W1965304265 countsByYear W19653042652019 @default.
• W1965304265 countsByYear W19653042652020 @default.
• W1965304265 countsByYear W19653042652021 @default.
• W1965304265 countsByYear W19653042652022 @default.
• W1965304265 countsByYear W19653042652023 @default.
• W1965304265 crossrefType "journal-article" @default.
• W1965304265 hasAuthorship W1965304265A5033871994 @default.
• W1965304265 hasAuthorship W1965304265A5072133376 @default.
• W1965304265 hasConcept C104317684 @default.
• W1965304265 hasConcept C126322002 @default.
• W1965304265 hasConcept C129374314 @default.
• W1965304265 hasConcept C189976730 @default.
• W1965304265 hasConcept C203014093 @default.
• W1965304265 hasConcept C2776090121 @default.
• W1965304265 hasConcept C2777371288 @default.
• W1965304265 hasConcept C2777701055 @default.
• W1965304265 hasConcept C2778690821 @default.
• W1965304265 hasConcept C28651165 @default.
• W1965304265 hasConcept C40767141 @default.
• W1965304265 hasConcept C49382859 @default.
• W1965304265 hasConcept C55493867 @default.
• W1965304265 hasConcept C71924100 @default.
• W1965304265 hasConcept C86803240 @default.
• W1965304265 hasConcept C8891405 @default.
• W1965304265 hasConceptScore W1965304265C104317684 @default.
• W1965304265 hasConceptScore W1965304265C126322002 @default.
• W1965304265 hasConceptScore W1965304265C129374314 @default.
• W1965304265 hasConceptScore W1965304265C189976730 @default.
• W1965304265 hasConceptScore W1965304265C203014093 @default.
• W1965304265 hasConceptScore W1965304265C2776090121 @default.
• W1965304265 hasConceptScore W1965304265C2777371288 @default.
• W1965304265 hasConceptScore W1965304265C2777701055 @default.
• W1965304265 hasConceptScore W1965304265C2778690821 @default.
• W1965304265 hasConceptScore W1965304265C28651165 @default.
• W1965304265 hasConceptScore W1965304265C40767141 @default.
• W1965304265 hasConceptScore W1965304265C49382859 @default.
• W1965304265 hasConceptScore W1965304265C55493867 @default.
• W1965304265 hasConceptScore W1965304265C71924100 @default.
• W1965304265 hasConceptScore W1965304265C86803240 @default.
• W1965304265 hasConceptScore W1965304265C8891405 @default.
• W1965304265 hasIssue "8" @default.
• W1965304265 hasLocation W19653042651 @default.
• W1965304265 hasOpenAccess W1965304265 @default.
• W1965304265 hasPrimaryLocation W19653042651 @default.
• W1965304265 hasRelatedWork W1481598923 @default.
• W1965304265 hasRelatedWork W2027843298 @default.
• W1965304265 hasRelatedWork W2070684861 @default.
• W1965304265 hasRelatedWork W2070789182 @default.
• W1965304265 hasRelatedWork W2083489699 @default.
• W1965304265 hasRelatedWork W2408956129 @default.
• W1965304265 hasRelatedWork W2409981128 @default.
• W1965304265 hasRelatedWork W2411467451 @default.
• W1965304265 hasRelatedWork W2472438389 @default.
• W1965304265 hasRelatedWork W4249205621 @default.
• W1965304265 hasVolume "45" @default.
• W1965304265 isParatext "false" @default.
• W1965304265 isRetracted "false" @default.
• W1965304265 magId "1965304265" @default.
• W1965304265 workType "article" @default.