FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965305027> ?p ?o ?g. }

• W1965305027 abstract "Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of c-KIT in canine GISTs; specifically, we investigated activating mutations in exons 8, 9, 11, 13, and 17 of c-KIT and exons 12, 14, and 18 of platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), all of which have been implicated in human GISTs.Seventeen canine GISTs all confirmed to be positive for KIT immunostaining were studied. Exons 8, 9, 11, 13 and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA, were amplified from DNA isolated from formalin-fixed paraffin-embedded samples.Of these seventeen cases, six amplicons of exon 11 of c-KIT showed aberrant bands on gel electrophoresis. Sequencing of these amplicons revealed heterozygous in-frame deletions in six cases. The mutations include two different but overlapping six base pair deletions. Exons 8, 9, 13, and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA had no abnormalities detected by electrophoresis and sequencing did not reveal any mutations, other than synonymous single nucleotide polymorphisms (SNPs) found in exon 11 of c-KIT and exons 12 and 14 of PDGFRA.The deletion mutations detected in canine GISTs are similar to those previously found in the juxtamembrane domain of c-KIT in canine cutaneous mast cell tumors in our laboratory as well as to those reported in human GISTs. Interestingly, none of the other c-KIT or PDGFRA exons showed any abnormalities in our cases. This finding underlines the critical importance of c-KIT in the pathophysiology of canine GISTs. The expression of KIT and the identification of these activating mutations in c-KIT implicate KIT in the pathogenesis of these tumors. Our results indicate that mutations in c-KIT may be of prognostic significance and that targeting KIT may be a rational approach to treatment of these malignant tumors. This study further demonstrates that spontaneously occurring canine GISTs share molecular features with human GISTs and are an appropriate model for human GISTs." @default.
• W1965305027 created "2016-06-24" @default.
• W1965305027 creator A5003198305 @default.
• W1965305027 creator A5034984666 @default.
• W1965305027 creator A5037658952 @default.
• W1965305027 creator A5083024771 @default.
• W1965305027 creator A5085854115 @default.
• W1965305027 date "2010-10-15" @default.
• W1965305027 modified "2023-10-15" @default.
• W1965305027 title "Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11" @default.
• W1965305027 cites W1514031343 @default.
• W1965305027 cites W1521633337 @default.
• W1965305027 cites W1549034776 @default.
• W1965305027 cites W1752312133 @default.
• W1965305027 cites W1778521318 @default.
• W1965305027 cites W1933891757 @default.
• W1965305027 cites W1964868967 @default.
• W1965305027 cites W1966319307 @default.
• W1965305027 cites W1972829319 @default.
• W1965305027 cites W1975344486 @default.
• W1965305027 cites W1983235255 @default.
• W1965305027 cites W1985622294 @default.
• W1965305027 cites W1986936995 @default.
• W1965305027 cites W1987838834 @default.
• W1965305027 cites W1988821060 @default.
• W1965305027 cites W1991175004 @default.
• W1965305027 cites W2006556639 @default.
• W1965305027 cites W2007328596 @default.
• W1965305027 cites W2013709527 @default.
• W1965305027 cites W2014183075 @default.
• W1965305027 cites W2016576372 @default.
• W1965305027 cites W2024702786 @default.
• W1965305027 cites W2037751628 @default.
• W1965305027 cites W2039045990 @default.
• W1965305027 cites W2041415161 @default.
• W1965305027 cites W2046381204 @default.
• W1965305027 cites W2046804728 @default.
• W1965305027 cites W2051515492 @default.
• W1965305027 cites W2064375212 @default.
• W1965305027 cites W2070268639 @default.
• W1965305027 cites W2071008257 @default.
• W1965305027 cites W2072103710 @default.
• W1965305027 cites W2081921707 @default.
• W1965305027 cites W2106363223 @default.
• W1965305027 cites W2111550284 @default.
• W1965305027 cites W2114611642 @default.
• W1965305027 cites W2120997246 @default.
• W1965305027 cites W2121609639 @default.
• W1965305027 cites W2122794531 @default.
• W1965305027 cites W2123571541 @default.
• W1965305027 cites W2128126075 @default.
• W1965305027 cites W2129702865 @default.
• W1965305027 cites W2133771964 @default.
• W1965305027 cites W2140626630 @default.
• W1965305027 cites W2146860018 @default.
• W1965305027 cites W2149908540 @default.
• W1965305027 cites W2159467875 @default.
• W1965305027 cites W2166199724 @default.
• W1965305027 cites W2168030213 @default.
• W1965305027 cites W2168272823 @default.
• W1965305027 cites W2171620774 @default.
• W1965305027 doi "https://doi.org/10.1186/1471-2407-10-559" @default.
• W1965305027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2970610" @default.
• W1965305027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20950418" @default.
• W1965305027 hasPublicationYear "2010" @default.
• W1965305027 type Work @default.
• W1965305027 sameAs 1965305027 @default.
• W1965305027 citedByCount "64" @default.
• W1965305027 countsByYear W19653050272012 @default.
• W1965305027 countsByYear W19653050272013 @default.
• W1965305027 countsByYear W19653050272014 @default.
• W1965305027 countsByYear W19653050272015 @default.
• W1965305027 countsByYear W19653050272016 @default.
• W1965305027 countsByYear W19653050272017 @default.
• W1965305027 countsByYear W19653050272018 @default.
• W1965305027 countsByYear W19653050272019 @default.
• W1965305027 countsByYear W19653050272020 @default.
• W1965305027 countsByYear W19653050272021 @default.
• W1965305027 countsByYear W19653050272022 @default.
• W1965305027 countsByYear W19653050272023 @default.
• W1965305027 crossrefType "journal-article" @default.
• W1965305027 hasAuthorship W1965305027A5003198305 @default.
• W1965305027 hasAuthorship W1965305027A5034984666 @default.
• W1965305027 hasAuthorship W1965305027A5037658952 @default.
• W1965305027 hasAuthorship W1965305027A5083024771 @default.
• W1965305027 hasAuthorship W1965305027A5085854115 @default.
• W1965305027 hasBestOaLocation W19653050271 @default.
• W1965305027 hasConcept C104317684 @default.
• W1965305027 hasConcept C109159458 @default.
• W1965305027 hasConcept C142724271 @default.
• W1965305027 hasConcept C153911025 @default.
• W1965305027 hasConcept C16930146 @default.
• W1965305027 hasConcept C176944494 @default.
• W1965305027 hasConcept C2022786 @default.
• W1965305027 hasConcept C2775922572 @default.
• W1965305027 hasConcept C28328180 @default.
• W1965305027 hasConcept C2910840531 @default.
• W1965305027 hasConcept C36823959 @default.
• W1965305027 hasConcept C37307934 @default.
• W1965305027 hasConcept C49105822 @default.

• next