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• W1965331353 abstract "The kinetics of opening of the DNA quadruplex formed by the human telomeric repeat have been investigated using real-time fluorescence resonance energy transfer (FRET) measurements with a peptide nucleic acid (PNA) trap. It has been found that this opening is zero-order with respect to PNA, indicating that the initial step is a rate-limiting internal rearrangement of the quadruplex. A study of the temperature dependence of the rate of quadruplex opening was performed and the activation energy of the process estimated to be 98 +/- 8 kJ mol(-1)." @default.
• W1965331353 created "2016-06-24" @default.
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• W1965331353 date "2003-03-11" @default.
• W1965331353 modified "2023-10-17" @default.
• W1965331353 title "Kinetics of Unfolding the Human Telomeric DNA Quadruplex Using a PNA Trap" @default.
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• W1965331353 doi "https://doi.org/10.1021/ja029149w" @default.
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