Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965333604> ?p ?o ?g. }
- W1965333604 endingPage "32" @default.
- W1965333604 startingPage "20" @default.
- W1965333604 abstract "The formation of layered structure of the mammalian neocortex requires a fine organized migration of post-mitotic neurons during early development. However, whether the radial migration is regulated by NMDA receptor and specific subunits remains contradictory and unknown. Here, we reported that in the developing rat cortex, migration of presumptive layer II/III neurons to their deserved destination was regulated by NMDA receptors with GluN2B but not GluN2A subunit. Using in utero electroporation of small interference RNA (siRNA) of distinct NMDA receptor subunits, we found that knockdown GluN1 and GluN2B subunits dramatically delayed the neuronal migration to proper layer II/III, while improperly stayed at lower layers or even the germinal regions, without changing the cell fate. In contrast, knockdown of GluN2A subunit did not impair the neuronal migration. Additionally, the ecotopic neurons by GluN2B RNAi developed to well dendritic differentiation, while the ones by GluN1 RNAi still kept morphology of migrating neurons. Therefore, GluN2B subunit of NMDA receptor plays an essential role in regulating proper neuronal migration and cortical lamination." @default.
- W1965333604 created "2016-06-24" @default.
- W1965333604 creator A5001173266 @default.
- W1965333604 creator A5011241874 @default.
- W1965333604 creator A5012333556 @default.
- W1965333604 creator A5025261908 @default.
- W1965333604 creator A5043139433 @default.
- W1965333604 creator A5050772464 @default.
- W1965333604 creator A5055941214 @default.
- W1965333604 creator A5058958720 @default.
- W1965333604 creator A5080806594 @default.
- W1965333604 date "2015-06-01" @default.
- W1965333604 modified "2023-10-14" @default.
- W1965333604 title "The GluN2B subunit of N-methy-D-asparate receptor regulates the radial migration of cortical neurons in vivo" @default.
- W1965333604 cites W1487546036 @default.
- W1965333604 cites W1561430338 @default.
- W1965333604 cites W1608349175 @default.
- W1965333604 cites W1642597095 @default.
- W1965333604 cites W1835974158 @default.
- W1965333604 cites W1949267176 @default.
- W1965333604 cites W1970690750 @default.
- W1965333604 cites W1974879622 @default.
- W1965333604 cites W1976416612 @default.
- W1965333604 cites W1979832807 @default.
- W1965333604 cites W1986618663 @default.
- W1965333604 cites W1986996949 @default.
- W1965333604 cites W1989385298 @default.
- W1965333604 cites W2013928206 @default.
- W1965333604 cites W2015182581 @default.
- W1965333604 cites W2017241296 @default.
- W1965333604 cites W2018633903 @default.
- W1965333604 cites W2019297438 @default.
- W1965333604 cites W2020250576 @default.
- W1965333604 cites W2025678185 @default.
- W1965333604 cites W2025868352 @default.
- W1965333604 cites W2025993162 @default.
- W1965333604 cites W2027844417 @default.
- W1965333604 cites W2029545679 @default.
- W1965333604 cites W2032596004 @default.
- W1965333604 cites W2032950480 @default.
- W1965333604 cites W2036650593 @default.
- W1965333604 cites W2037852973 @default.
- W1965333604 cites W2038783205 @default.
- W1965333604 cites W2040053885 @default.
- W1965333604 cites W2040434011 @default.
- W1965333604 cites W2041024256 @default.
- W1965333604 cites W2045344243 @default.
- W1965333604 cites W2046655629 @default.
- W1965333604 cites W2063620761 @default.
- W1965333604 cites W2069314859 @default.
- W1965333604 cites W2072471457 @default.
- W1965333604 cites W2074262563 @default.
- W1965333604 cites W2074683128 @default.
- W1965333604 cites W2077630079 @default.
- W1965333604 cites W2078167209 @default.
- W1965333604 cites W2080137645 @default.
- W1965333604 cites W2082791664 @default.
- W1965333604 cites W2084462219 @default.
- W1965333604 cites W2089064616 @default.
- W1965333604 cites W2089374585 @default.
- W1965333604 cites W2092265956 @default.
- W1965333604 cites W2099378585 @default.
- W1965333604 cites W2121009504 @default.
- W1965333604 cites W2130017714 @default.
- W1965333604 cites W2130907163 @default.
- W1965333604 cites W2131016346 @default.
- W1965333604 cites W2134711325 @default.
- W1965333604 cites W2139074300 @default.
- W1965333604 cites W2139374120 @default.
- W1965333604 cites W2146656050 @default.
- W1965333604 cites W2150374394 @default.
- W1965333604 cites W2159729949 @default.
- W1965333604 cites W2164674870 @default.
- W1965333604 cites W2166802510 @default.
- W1965333604 cites W2167945354 @default.
- W1965333604 cites W2094379837 @default.
- W1965333604 doi "https://doi.org/10.1016/j.brainres.2015.03.031" @default.
- W1965333604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25838242" @default.
- W1965333604 hasPublicationYear "2015" @default.
- W1965333604 type Work @default.
- W1965333604 sameAs 1965333604 @default.
- W1965333604 citedByCount "16" @default.
- W1965333604 countsByYear W19653336042017 @default.
- W1965333604 countsByYear W19653336042018 @default.
- W1965333604 countsByYear W19653336042019 @default.
- W1965333604 countsByYear W19653336042020 @default.
- W1965333604 countsByYear W19653336042021 @default.
- W1965333604 countsByYear W19653336042022 @default.
- W1965333604 countsByYear W19653336042023 @default.
- W1965333604 crossrefType "journal-article" @default.
- W1965333604 hasAuthorship W1965333604A5001173266 @default.
- W1965333604 hasAuthorship W1965333604A5011241874 @default.
- W1965333604 hasAuthorship W1965333604A5012333556 @default.
- W1965333604 hasAuthorship W1965333604A5025261908 @default.
- W1965333604 hasAuthorship W1965333604A5043139433 @default.
- W1965333604 hasAuthorship W1965333604A5050772464 @default.
- W1965333604 hasAuthorship W1965333604A5055941214 @default.
- W1965333604 hasAuthorship W1965333604A5058958720 @default.