Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965337327> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1965337327 endingPage "337" @default.
- W1965337327 startingPage "325" @default.
- W1965337327 abstract "The cardiovascular response to the K(+) channel inhibitor 4-aminopyridine in anaesthetized rats was analysed. 4-Aminopyridine produced a biphasic pressor response. First, it increased blood pressure, total peripheral vascular resistance, cardiac output and stroke volume. Nitric oxide synthase (NOS) inhibitor augmented the tension response; reserpine, phentolamine, propranolol, scopolamine, atropine, adrenalectomy, indomethacin, angiotensin AT(1) and endothelin ET(A) receptor antagonists had no effect. Subsequently, heart rate increased, but total peripheral vascular resistance was no longer elevated. Reserpine and propranolol abolished the tachycardia. An elevated late tension occurred after propranolol and NOS inhibitor but not reserpine or phentolamine+NOS inhibitor. The peripherally acting 3,4-diaminopyridine produced similar responses. 4-Aminopyridine contracted isolated aortic rings also after denudation. These results are compatible with that the immediate tension response resulted from closure of vascular smooth muscle K(+) channels, and that closure of presynaptic K(+) channels in peripheral sympathetic nerves subsequently activated noradrenaline release, beta-adrenoceptors and tachycardia, while nitric oxide counter-acted a concomitant alpha-adrenergic vasoconstriction." @default.
- W1965337327 created "2016-06-24" @default.
- W1965337327 creator A5073244225 @default.
- W1965337327 date "2002-10-01" @default.
- W1965337327 modified "2023-09-26" @default.
- W1965337327 title "Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine" @default.
- W1965337327 cites W134363133 @default.
- W1965337327 cites W160708530 @default.
- W1965337327 cites W1753089048 @default.
- W1965337327 cites W1969187588 @default.
- W1965337327 cites W1977629503 @default.
- W1965337327 cites W1980715848 @default.
- W1965337327 cites W1981889097 @default.
- W1965337327 cites W1982061543 @default.
- W1965337327 cites W1986117743 @default.
- W1965337327 cites W1986263025 @default.
- W1965337327 cites W1989247510 @default.
- W1965337327 cites W1991556034 @default.
- W1965337327 cites W1997613458 @default.
- W1965337327 cites W2011109963 @default.
- W1965337327 cites W2038910392 @default.
- W1965337327 cites W2040668875 @default.
- W1965337327 cites W2058150188 @default.
- W1965337327 cites W2062782850 @default.
- W1965337327 cites W2073924708 @default.
- W1965337327 cites W2078829939 @default.
- W1965337327 cites W2082201595 @default.
- W1965337327 cites W2088939652 @default.
- W1965337327 cites W2092183051 @default.
- W1965337327 cites W2118571380 @default.
- W1965337327 cites W2118644794 @default.
- W1965337327 cites W2125766324 @default.
- W1965337327 cites W2171678141 @default.
- W1965337327 cites W2287244414 @default.
- W1965337327 cites W2395707267 @default.
- W1965337327 cites W4211240533 @default.
- W1965337327 doi "https://doi.org/10.1016/s0014-2999(02)02306-3" @default.
- W1965337327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12359274" @default.
- W1965337327 hasPublicationYear "2002" @default.
- W1965337327 type Work @default.
- W1965337327 sameAs 1965337327 @default.
- W1965337327 citedByCount "19" @default.
- W1965337327 countsByYear W19653373272012 @default.
- W1965337327 countsByYear W19653373272013 @default.
- W1965337327 countsByYear W19653373272015 @default.
- W1965337327 countsByYear W19653373272016 @default.
- W1965337327 countsByYear W19653373272017 @default.
- W1965337327 countsByYear W19653373272020 @default.
- W1965337327 crossrefType "journal-article" @default.
- W1965337327 hasAuthorship W1965337327A5073244225 @default.
- W1965337327 hasConcept C126322002 @default.
- W1965337327 hasConcept C134018914 @default.
- W1965337327 hasConcept C170493617 @default.
- W1965337327 hasConcept C185592680 @default.
- W1965337327 hasConcept C2777842393 @default.
- W1965337327 hasConcept C2778151854 @default.
- W1965337327 hasConcept C2778938600 @default.
- W1965337327 hasConcept C2780253649 @default.
- W1965337327 hasConcept C2780745239 @default.
- W1965337327 hasConcept C42219234 @default.
- W1965337327 hasConcept C58245268 @default.
- W1965337327 hasConcept C71924100 @default.
- W1965337327 hasConcept C84393581 @default.
- W1965337327 hasConceptScore W1965337327C126322002 @default.
- W1965337327 hasConceptScore W1965337327C134018914 @default.
- W1965337327 hasConceptScore W1965337327C170493617 @default.
- W1965337327 hasConceptScore W1965337327C185592680 @default.
- W1965337327 hasConceptScore W1965337327C2777842393 @default.
- W1965337327 hasConceptScore W1965337327C2778151854 @default.
- W1965337327 hasConceptScore W1965337327C2778938600 @default.
- W1965337327 hasConceptScore W1965337327C2780253649 @default.
- W1965337327 hasConceptScore W1965337327C2780745239 @default.
- W1965337327 hasConceptScore W1965337327C42219234 @default.
- W1965337327 hasConceptScore W1965337327C58245268 @default.
- W1965337327 hasConceptScore W1965337327C71924100 @default.
- W1965337327 hasConceptScore W1965337327C84393581 @default.
- W1965337327 hasIssue "3" @default.
- W1965337327 hasLocation W19653373271 @default.
- W1965337327 hasLocation W19653373272 @default.
- W1965337327 hasOpenAccess W1965337327 @default.
- W1965337327 hasPrimaryLocation W19653373271 @default.
- W1965337327 hasRelatedWork W1965337327 @default.
- W1965337327 hasRelatedWork W1992842231 @default.
- W1965337327 hasRelatedWork W2011792914 @default.
- W1965337327 hasRelatedWork W2057537203 @default.
- W1965337327 hasRelatedWork W2091022983 @default.
- W1965337327 hasRelatedWork W2093919627 @default.
- W1965337327 hasRelatedWork W2135033561 @default.
- W1965337327 hasRelatedWork W2411899134 @default.
- W1965337327 hasRelatedWork W2748952813 @default.
- W1965337327 hasRelatedWork W4251709836 @default.
- W1965337327 hasVolume "452" @default.
- W1965337327 isParatext "false" @default.
- W1965337327 isRetracted "false" @default.
- W1965337327 magId "1965337327" @default.
- W1965337327 workType "article" @default.