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- W1965350385 endingPage "31" @default.
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- W1965350385 abstract "Intracellular calcium release is a fundamental signaling mechanism in all eukaryotic cells. The ryanodine receptor (RyR) and inositol 1,4,5-trisphosphate receptor (IP3R) are intracellular calcium release channels. Both channels can be regulated by calcium and calmodulin (CaM). In this review we will first discuss the role of calcium as an activator and inactivator of the IP3R, concluding that calcium is the most important regulator of the IP3R. In the second part we will further focus on the role of CaM as modulator of the IP3R, using results of the voltage-dependent Ca2+ channels and the RyR as reference material. Here we conclude that despite the fact that different CaM-binding sites have been characterized, their function for the IP3R remains elusive. In the third part we will discuss the possible functional role of CaM in IP3-induced Ca2+ release (IICR) by direct and indirect mechanisms. Special attention will be given to the Ca2+-binding proteins (CaBPs) that were shown to activate the IP3R in the absence of IP3." @default.
- W1965350385 created "2016-06-24" @default.
- W1965350385 creator A5019565239 @default.
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- W1965350385 creator A5047593997 @default.
- W1965350385 creator A5049588515 @default.
- W1965350385 creator A5061905092 @default.
- W1965350385 creator A5082879421 @default.
- W1965350385 date "2002-11-01" @default.
- W1965350385 modified "2023-09-23" @default.
- W1965350385 title "The role of calmodulin for inositol 1,4,5-trisphosphate receptor function" @default.
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