Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965362242> ?p ?o ?g. }
- W1965362242 endingPage "4" @default.
- W1965362242 startingPage "1" @default.
- W1965362242 abstract "Although the endocannabinoid system (ECS) has been implicated in brain development and various psychiatric disorders, precise mechanisms of the ECS on mood and anxiety disorders remain unclear. Here, we have investigated developmental and disease-related expression pattern of the cannabinoid receptor 1 (CB1) and the cannabinoid receptor 2 (CB2) genes in the dorsolateral prefrontal cortex (PFC) of humans. Using mice selectively bred for high and low fear, we further investigated potential association between fear memory and the cannabinoid receptor expression in the brain. The CB1, not the CB2, mRNA levels in the PFC gradually decrease during postnatal development ranging in age from birth to 50 years (r2 > 0.6 & adj. p < 0.05). The CB1 levels in the PFC of major depression patients were higher when compared to the age-matched controls (adj. p < 0.05). In mice, the CB1, not the CB2, levels in the PFC were positively correlated with freezing behavior in classical fear conditioning (p < 0.05). These results suggest that the CB1 in the PFC may play a significant role in regulating mood and anxiety symptoms. Our study demonstrates the advantage of utilizing data from postmortem brain tissue and a mouse model of fear to enhance our understanding of the role of the cannabinoid receptors in mood and anxiety disorders." @default.
- W1965362242 created "2016-06-24" @default.
- W1965362242 creator A5007081398 @default.
- W1965362242 creator A5071880893 @default.
- W1965362242 date "2011-09-01" @default.
- W1965362242 modified "2023-09-23" @default.
- W1965362242 title "Cb1 receptor-mediated signaling emerges as a novel lead to evidence-based treatment development for stress-related psychopathology" @default.
- W1965362242 cites W1525600305 @default.
- W1965362242 cites W1534942440 @default.
- W1965362242 cites W1591647183 @default.
- W1965362242 cites W1689156510 @default.
- W1965362242 cites W1964014092 @default.
- W1965362242 cites W1965229720 @default.
- W1965362242 cites W1969888326 @default.
- W1965362242 cites W1970455198 @default.
- W1965362242 cites W1971466205 @default.
- W1965362242 cites W1976171908 @default.
- W1965362242 cites W1977774953 @default.
- W1965362242 cites W1978762354 @default.
- W1965362242 cites W1980718841 @default.
- W1965362242 cites W1980826175 @default.
- W1965362242 cites W1982291289 @default.
- W1965362242 cites W1984109009 @default.
- W1965362242 cites W1987096289 @default.
- W1965362242 cites W1989073099 @default.
- W1965362242 cites W1989463851 @default.
- W1965362242 cites W2000809493 @default.
- W1965362242 cites W2004071734 @default.
- W1965362242 cites W2004284072 @default.
- W1965362242 cites W2008171418 @default.
- W1965362242 cites W2008273719 @default.
- W1965362242 cites W2009594014 @default.
- W1965362242 cites W2009732294 @default.
- W1965362242 cites W2018005554 @default.
- W1965362242 cites W2023585608 @default.
- W1965362242 cites W2024653583 @default.
- W1965362242 cites W2025257777 @default.
- W1965362242 cites W2025390026 @default.
- W1965362242 cites W2027352187 @default.
- W1965362242 cites W2028623309 @default.
- W1965362242 cites W2029181309 @default.
- W1965362242 cites W2033835916 @default.
- W1965362242 cites W2034331710 @default.
- W1965362242 cites W2039708012 @default.
- W1965362242 cites W2041670206 @default.
- W1965362242 cites W2043621158 @default.
- W1965362242 cites W2045484191 @default.
- W1965362242 cites W2068119876 @default.
- W1965362242 cites W2073926336 @default.
- W1965362242 cites W2074290211 @default.
- W1965362242 cites W2074698946 @default.
- W1965362242 cites W2076043532 @default.
- W1965362242 cites W2083371696 @default.
- W1965362242 cites W2084163988 @default.
- W1965362242 cites W2084663855 @default.
- W1965362242 cites W2085741941 @default.
- W1965362242 cites W2086623168 @default.
- W1965362242 cites W2088851718 @default.
- W1965362242 cites W2093376597 @default.
- W1965362242 cites W2094389602 @default.
- W1965362242 cites W2096693006 @default.
- W1965362242 cites W2099617879 @default.
- W1965362242 cites W2106243833 @default.
- W1965362242 cites W2111110292 @default.
- W1965362242 cites W2118091961 @default.
- W1965362242 cites W2119735577 @default.
- W1965362242 cites W2123249845 @default.
- W1965362242 cites W2123688268 @default.
- W1965362242 cites W2124037107 @default.
- W1965362242 cites W2124248227 @default.
- W1965362242 cites W2124512064 @default.
- W1965362242 cites W2133859389 @default.
- W1965362242 cites W2143861132 @default.
- W1965362242 cites W2143870303 @default.
- W1965362242 cites W2147814145 @default.
- W1965362242 cites W2149183149 @default.
- W1965362242 cites W2152835445 @default.
- W1965362242 cites W2153143530 @default.
- W1965362242 cites W2157977435 @default.
- W1965362242 cites W2168003262 @default.
- W1965362242 cites W4241363254 @default.
- W1965362242 cites W51427809 @default.
- W1965362242 doi "https://doi.org/10.1016/j.neulet.2011.07.011" @default.
- W1965362242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21787837" @default.
- W1965362242 hasPublicationYear "2011" @default.
- W1965362242 type Work @default.
- W1965362242 sameAs 1965362242 @default.
- W1965362242 citedByCount "3" @default.
- W1965362242 countsByYear W19653622422012 @default.
- W1965362242 crossrefType "journal-article" @default.
- W1965362242 hasAuthorship W1965362242A5007081398 @default.
- W1965362242 hasAuthorship W1965362242A5071880893 @default.
- W1965362242 hasConcept C118552586 @default.
- W1965362242 hasConcept C123273963 @default.
- W1965362242 hasConcept C126322002 @default.
- W1965362242 hasConcept C134018914 @default.
- W1965362242 hasConcept C148001335 @default.
- W1965362242 hasConcept C15744967 @default.