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- W1965366240 endingPage "206" @default.
- W1965366240 startingPage "189" @default.
- W1965366240 abstract "With the purification and cloning of the interferon gamma (IFN-γ) receptor chains the mechanism of IFN-γ action and the resultant signal transduction events were delineated in remarkable detail. The interferon gamma (IFN-γ) receptor complex consists of two chains: IFN-γR1, the ligand-binding chain, and IFN-γR2, the accessory chain. Binding of IFN-γ causes oligomerization of the two IFN-γ receptor subunits, IFN-γR1 and IFN-γR2, which initiates the signal transduction events: activation of Jakl and Jak2 receptor associated protein tyrosine kinases, phosphorylation of the IFN-γR1 intracellular domain on Tyr440 followed by phosphorylation and activation of Stat1α, the latent transcriptional factor. With all these steps established, the IFN-γ receptor complex has provided the basic model for understanding the receptors for other members of the family of class II cytokine receptors." @default.
- W1965366240 created "2016-06-24" @default.
- W1965366240 creator A5001004057 @default.
- W1965366240 creator A5019567093 @default.
- W1965366240 creator A5035780912 @default.
- W1965366240 creator A5061470762 @default.
- W1965366240 creator A5063571201 @default.
- W1965366240 creator A5084391691 @default.
- W1965366240 date "1997-09-01" @default.
- W1965366240 modified "2023-09-24" @default.
- W1965366240 title "The interferon gamma (IFN-γ) receptor: a paradigm for the multichain cytokine receptor" @default.
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