FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965366931> ?p ?o ?g. }

• W1965366931 abstract "Abstract Background Si-Wu-Tang (SWT), comprising the combination of four herbs, Paeoniae, Angelicae, Chuanxiong and Rehmanniae, is one of the most popular traditional oriental medicines for women’s diseases. In our previous study, the microarray gene expression profiles of SWT on breast cancer cell line MCF-7 were found similar to the effect of β-estradiol (E2) on MCF-7 cells in the Connectivity Map database. Methods Further data analysis was conducted to find the main similarities and differences between the effects of SWT and E2 on MCF-7 gene expression. The cell proliferation assay on MCF-7 (ER-positive) and MDA-MB-231 (ER-negative) cells were used to examine such estrogenic activity. The estrogenic potency of SWT was further confirmed by estrogen-responsive element (ERE) luciferase reporter assay in MCF-7 cells. Results Many estrogen regulated genes strongly up-regulated by E2 were similarly up-regulated by SWT, e.g., GREB1 , PGR and EGR3 . Of interest with regard to safety of SWT, the oncogenes MYBL1 and RET were strongly induced by E2 but not by SWT. Quantitative RT-PCR analysis revealed a highly concordant expression change in selected genes with data obtained by microarrays. Further supporting SWT’s estrogenic activity, in MCF-7 but not in MDA-MB-231 cells, SWT stimulated cell growth at lower concentrations (< 3.0 mg/ml), while at high concentrations, it inhibits the growth of both cell lines. The growth inhibitory potency of SWT was significantly higher in MDA-MB-231 than in MCF-7 cells. The SWT-induced cell growth of MCF-7 could be blocked by addition of the estrogen receptor antagonist tamoxifen. In addition, SWT was able to activate the ERE activity at lower concentrations. The herbal components Angelicae, Chuanxiong and Rehmanniae at lower concentrations (< 3.0 mg/ml) also showed growth-inducing and ERE-activating activity in MCF-7 cells. Conclusions These results revealed a new mechanism to support the clinical use of SWT for estrogen related diseases and possibly for cancer prevention. This study also demonstrated the feasibility of using microarray transcriptional profiling to discover phytoestrogenic components that are present in natural products." @default.
• W1965366931 created "2016-06-24" @default.
• W1965366931 creator A5007166385 @default.
• W1965366931 creator A5014245128 @default.
• W1965366931 creator A5025393961 @default.
• W1965366931 creator A5043439155 @default.
• W1965366931 creator A5045201341 @default.
• W1965366931 creator A5058188339 @default.
• W1965366931 creator A5073706747 @default.
• W1965366931 creator A5080076598 @default.
• W1965366931 creator A5081004832 @default.
• W1965366931 creator A5088070159 @default.
• W1965366931 date "2013-01-10" @default.
• W1965366931 modified "2023-10-16" @default.
• W1965366931 title "Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity" @default.
• W1965366931 cites W1964226926 @default.
• W1965366931 cites W1966071231 @default.
• W1965366931 cites W1966092733 @default.
• W1965366931 cites W1971864849 @default.
• W1965366931 cites W1971909806 @default.
• W1965366931 cites W1973564912 @default.
• W1965366931 cites W1979660342 @default.
• W1965366931 cites W1979919537 @default.
• W1965366931 cites W1980109556 @default.
• W1965366931 cites W1981761625 @default.
• W1965366931 cites W1994160613 @default.
• W1965366931 cites W1994728053 @default.
• W1965366931 cites W2002310413 @default.
• W1965366931 cites W2003520577 @default.
• W1965366931 cites W2003685376 @default.
• W1965366931 cites W2003726111 @default.
• W1965366931 cites W2013604894 @default.
• W1965366931 cites W2021990634 @default.
• W1965366931 cites W2026695532 @default.
• W1965366931 cites W2035587817 @default.
• W1965366931 cites W2037460676 @default.
• W1965366931 cites W2051419174 @default.
• W1965366931 cites W2053356055 @default.
• W1965366931 cites W2056830390 @default.
• W1965366931 cites W2058683100 @default.
• W1965366931 cites W2059550141 @default.
• W1965366931 cites W2062656956 @default.
• W1965366931 cites W2069162970 @default.
• W1965366931 cites W2070431799 @default.
• W1965366931 cites W2072977569 @default.
• W1965366931 cites W2075177908 @default.
• W1965366931 cites W2090256594 @default.
• W1965366931 cites W2094139685 @default.
• W1965366931 cites W2103313840 @default.
• W1965366931 cites W2104000690 @default.
• W1965366931 cites W2108934854 @default.
• W1965366931 cites W2119769325 @default.
• W1965366931 cites W2121604817 @default.
• W1965366931 cites W2122759376 @default.
• W1965366931 cites W2124318493 @default.
• W1965366931 cites W2126964476 @default.
• W1965366931 cites W2140418048 @default.
• W1965366931 cites W2142733123 @default.
• W1965366931 cites W2149680578 @default.
• W1965366931 cites W2150926065 @default.
• W1965366931 cites W2169110289 @default.
• W1965366931 cites W2169318796 @default.
• W1965366931 cites W4297913676 @default.
• W1965366931 doi "https://doi.org/10.1186/1472-6882-13-11" @default.
• W1965366931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3637310" @default.
• W1965366931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23305139" @default.
• W1965366931 hasPublicationYear "2013" @default.
• W1965366931 type Work @default.
• W1965366931 sameAs 1965366931 @default.
• W1965366931 citedByCount "25" @default.
• W1965366931 countsByYear W19653669312013 @default.
• W1965366931 countsByYear W19653669312014 @default.
• W1965366931 countsByYear W19653669312015 @default.
• W1965366931 countsByYear W19653669312016 @default.
• W1965366931 countsByYear W19653669312017 @default.
• W1965366931 countsByYear W19653669312018 @default.
• W1965366931 countsByYear W19653669312019 @default.
• W1965366931 countsByYear W19653669312020 @default.
• W1965366931 countsByYear W19653669312022 @default.
• W1965366931 crossrefType "journal-article" @default.
• W1965366931 hasAuthorship W1965366931A5007166385 @default.
• W1965366931 hasAuthorship W1965366931A5014245128 @default.
• W1965366931 hasAuthorship W1965366931A5025393961 @default.
• W1965366931 hasAuthorship W1965366931A5043439155 @default.
• W1965366931 hasAuthorship W1965366931A5045201341 @default.
• W1965366931 hasAuthorship W1965366931A5058188339 @default.
• W1965366931 hasAuthorship W1965366931A5073706747 @default.
• W1965366931 hasAuthorship W1965366931A5080076598 @default.
• W1965366931 hasAuthorship W1965366931A5081004832 @default.
• W1965366931 hasAuthorship W1965366931A5088070159 @default.
• W1965366931 hasBestOaLocation W19653669311 @default.
• W1965366931 hasConcept C104317684 @default.
• W1965366931 hasConcept C109541995 @default.
• W1965366931 hasConcept C121608353 @default.
• W1965366931 hasConcept C126322002 @default.
• W1965366931 hasConcept C1491633281 @default.
• W1965366931 hasConcept C150194340 @default.
• W1965366931 hasConcept C153911025 @default.
• W1965366931 hasConcept C18431079 @default.
• W1965366931 hasConcept C186836561 @default.

• next