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- W1965369905 abstract "Since the initial Mouse Models of Intestinal Neoplasia Workshop in 2000, considerable progress has been made in developing rodent models of colorectal cancer, and the terminology recommended by the group has largely been adopted by the scientific community. Newer models with multiple genetic alterations develop intestinal tumors that closely resemble their human counterparts in morphology, location, and behavior. These models, as well as those that develop local and distant metastasis, are important advances. Models derived from stem cell populations offer new tools for studying proliferative and quiescent stem cells and their roles in intestinal neoplasia. The creation and ongoing curation of a virtual slide box (http://mmgint.org) offers an opportunity to share histologic findings and have them assessed community-wide. Rodent models remain an invaluable tool for elucidating molecular pathways, identifying novel biomarkers, and devising innovative strategies to prevent and treat intestinal cancer." @default.
- W1965369905 created "2016-06-24" @default.
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- W1965369905 date "2013-04-01" @default.
- W1965369905 modified "2023-10-14" @default.
- W1965369905 title "Pathology of Rodent Models of Intestinal Cancer: Progress Report and Recommendations" @default.
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- W1965369905 doi "https://doi.org/10.1053/j.gastro.2013.01.067" @default.
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