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• W1965371036 endingPage "H1403" @default.
• W1965371036 startingPage "H1378" @default.
• W1965371036 abstract "We have developed a mathematical model of the mouse ventricular myocyte action potential (AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever possible, we used Markov models to represent the molecular structure and function of ion channels. The model includes detailed intracellular Ca2+ dynamics, with simulations of localized events such as sarcoplasmic Ca2+ release into a small intracellular volume bounded by the sarcolemma and sarcoplasmic reticulum. Transporter-mediated Ca2+ fluxes from the bulk cytosol are closely matched to the experimentally reported values and predict stimulation rate-dependent changes in Ca2+ transients. Our model reproduces the properties of cardiac myocytes from two different regions of the heart: the apex and the septum. The septum has a relatively prolonged AP, which reflects a relatively small contribution from the rapid transient outward K+ current in the septum. The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice." @default.
• W1965371036 created "2016-06-24" @default.
• W1965371036 creator A5005670100 @default.
• W1965371036 creator A5029686920 @default.
• W1965371036 creator A5049143581 @default.
• W1965371036 creator A5073612072 @default.
• W1965371036 creator A5089811873 @default.
• W1965371036 date "2004-09-01" @default.
• W1965371036 modified "2023-10-12" @default.
• W1965371036 title "Computer model of action potential of mouse ventricular myocytes" @default.
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