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- W1965371827 abstract "0601 Although a great deal of attention has been given to the mechanical properties of skeletal muscle during isometric and shortening contractions, much less is known about the mechanical behavior of skeletal muscle during lengthening contractions. Within this context, the mechanical behavior of skeletal muscle during lengthening and its dependence on mechanical loading state and myosin heavy chain (MyHC) isoform composition remains poorly defined. PURPOSE: The objective of this study was to determine the extent to which the elastic modulus (E) is dependent on the loading state and/or MyHC isoform composition of a muscle. METHODS: To achieve this objective, we manipulated the loading state and the MyHC isoform composition of the rodent soleus muscle by using the hindlimb suspension model and altering the thyroid status of the animal. Muscle length was set to Lo. The muscle was then stimulated at its optimal frequency and allowed to move onto the isometric plateau. The ergometer was instructed to perform a ramp stretch 450 ms following the onset of the isometric contraction. The amplitudes of ramp stretches used in this study were 0.5, 1, and 2 mm in length. This corresponds to strains of ∼1.5 to ∼6 % of Lo. RESULTS: Hindlimb suspension for 4 wks reduced soleus muscle mass by ∼40% (P < 0.001) and hyperthyroidism produced a significant shift in MyHC isoform composition. Stiffness was reduced by ∼80% (P <0.001). Hence, the greater loss in stiffness relative to that observed for muscle mass implies that something about the material properties was altered by muscle unloading. This is quantitatively described by the ∼40–60% loss in E (P <0.001). Regression analyses demonstrated that there was a weak relationship (if any) between MyHC isoform composition and E. CONCLUSION: With respect to the findings of this study the loss of stiffness is not simply proportional to the loss in cross-sectional area. Rather our findings clearly demonstrate that the stiffness is not just dependent on structural alterations (i.e., loss of physiological cross-sectional area) but also on material alterations (i.e., a reduction in stiffness normalized to the geometry of the muscle; elastic modulus). Supported in part by NIH 46856 (VJC)" @default.
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- W1965371827 date "2004-05-01" @default.
- W1965371827 modified "2023-09-25" @default.
- W1965371827 title "Mechanical Behavior of Skeletal Muscle during Stretch" @default.
- W1965371827 doi "https://doi.org/10.1097/00005768-200405001-00422" @default.
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