FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965372015> ?p ?o ?g. }

• W1965372015 endingPage "188" @default.
• W1965372015 startingPage "184" @default.
• W1965372015 abstract "Purpose To investigate the toxicity of nelfinavir, administered during preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer. Material and methods Twelve patients were treated with chemoradiotherapy to 50.4 Gy combined with capecitabine 825 mg/m2 BID. Three dose levels (DL) of nelfinavir were tested: 750 mg BID (DL1), 1250 mg BID (DL2) and an intermediate level of 1000 mg BID (DL3). Surgery was performed between 8 and 10 weeks after completion of CRT. Primary endpoint was dose-limiting toxicity (DLT), defined as any grade 3 or higher non-hematological or grade 4 or higher hematological toxicity. Results Eleven patients could be analyzed: 5 were treated in DL1, 3 in DL2 and 3 in DL3. The first 3 patients in DL1 did not develop a DLT. In DL2 one patient developed gr 3 diarrhea, 1 patient had gr 3 transaminase elevation and 1 patient had a gr 3 cholangitis with unknown cause. An intermediate dose level was tested in DL3. In this group 2 patients developed gr 3 diarrhea and 1 patient gr 3 transaminase elevation and gr 4 post-operative wound complication. Three patients achieved a pathological complete response (pCR). Conclusions Nelfinavir 750 mg BID was defined as the recommended phase II dose in combination with capecitabine and 50.4 Gy pre-operative radiotherapy in rectal cancer. First tumor response evaluations are promising, but a further phase II study is needed to get more information about efficacy of this treatment regimen." @default.
• W1965372015 created "2016-06-24" @default.
• W1965372015 creator A5023698533 @default.
• W1965372015 creator A5035664541 @default.
• W1965372015 creator A5044186726 @default.
• W1965372015 creator A5044305743 @default.
• W1965372015 creator A5050363025 @default.
• W1965372015 creator A5052617540 @default.
• W1965372015 creator A5058987737 @default.
• W1965372015 creator A5063175573 @default.
• W1965372015 creator A5069023434 @default.
• W1965372015 creator A5076040219 @default.
• W1965372015 creator A5078561640 @default.
• W1965372015 date "2013-05-01" @default.
• W1965372015 modified "2023-10-17" @default.
• W1965372015 title "Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer" @default.
• W1965372015 cites W1504454374 @default.
• W1965372015 cites W1977468182 @default.
• W1965372015 cites W1982768187 @default.
• W1965372015 cites W1983553990 @default.
• W1965372015 cites W1992098692 @default.
• W1965372015 cites W2002976877 @default.
• W1965372015 cites W2010112233 @default.
• W1965372015 cites W2016703488 @default.
• W1965372015 cites W2019702920 @default.
• W1965372015 cites W2036595545 @default.
• W1965372015 cites W2040050823 @default.
• W1965372015 cites W2043645215 @default.
• W1965372015 cites W2043929834 @default.
• W1965372015 cites W2044932421 @default.
• W1965372015 cites W2062494260 @default.
• W1965372015 cites W2076193144 @default.
• W1965372015 cites W2079046174 @default.
• W1965372015 cites W2080071021 @default.
• W1965372015 cites W2087675944 @default.
• W1965372015 cites W2091689893 @default.
• W1965372015 cites W2093583396 @default.
• W1965372015 cites W2112521802 @default.
• W1965372015 cites W2121695446 @default.
• W1965372015 cites W2129172946 @default.
• W1965372015 cites W2135364779 @default.
• W1965372015 cites W2144717403 @default.
• W1965372015 cites W2151092952 @default.
• W1965372015 cites W2160655529 @default.
• W1965372015 cites W2161581516 @default.
• W1965372015 cites W2167319223 @default.
• W1965372015 cites W2168280541 @default.
• W1965372015 cites W2388163742 @default.
• W1965372015 cites W4211147392 @default.
• W1965372015 doi "https://doi.org/10.1016/j.radonc.2013.03.023" @default.
• W1965372015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23647753" @default.
• W1965372015 hasPublicationYear "2013" @default.
• W1965372015 type Work @default.
• W1965372015 sameAs 1965372015 @default.
• W1965372015 citedByCount "41" @default.
• W1965372015 countsByYear W19653720152014 @default.
• W1965372015 countsByYear W19653720152015 @default.
• W1965372015 countsByYear W19653720152016 @default.
• W1965372015 countsByYear W19653720152017 @default.
• W1965372015 countsByYear W19653720152018 @default.
• W1965372015 countsByYear W19653720152019 @default.
• W1965372015 countsByYear W19653720152020 @default.
• W1965372015 countsByYear W19653720152021 @default.
• W1965372015 countsByYear W19653720152022 @default.
• W1965372015 crossrefType "journal-article" @default.
• W1965372015 hasAuthorship W1965372015A5023698533 @default.
• W1965372015 hasAuthorship W1965372015A5035664541 @default.
• W1965372015 hasAuthorship W1965372015A5044186726 @default.
• W1965372015 hasAuthorship W1965372015A5044305743 @default.
• W1965372015 hasAuthorship W1965372015A5050363025 @default.
• W1965372015 hasAuthorship W1965372015A5052617540 @default.
• W1965372015 hasAuthorship W1965372015A5058987737 @default.
• W1965372015 hasAuthorship W1965372015A5063175573 @default.
• W1965372015 hasAuthorship W1965372015A5069023434 @default.
• W1965372015 hasAuthorship W1965372015A5076040219 @default.
• W1965372015 hasAuthorship W1965372015A5078561640 @default.
• W1965372015 hasBestOaLocation W19653720152 @default.
• W1965372015 hasConcept C121608353 @default.
• W1965372015 hasConcept C126322002 @default.
• W1965372015 hasConcept C141071460 @default.
• W1965372015 hasConcept C142462285 @default.
• W1965372015 hasConcept C2777909004 @default.
• W1965372015 hasConcept C2778424827 @default.
• W1965372015 hasConcept C2779802037 @default.
• W1965372015 hasConcept C2781160516 @default.
• W1965372015 hasConcept C2781413609 @default.
• W1965372015 hasConcept C29730261 @default.
• W1965372015 hasConcept C2993143319 @default.
• W1965372015 hasConcept C3013748606 @default.
• W1965372015 hasConcept C31760486 @default.
• W1965372015 hasConcept C509974204 @default.
• W1965372015 hasConcept C512399662 @default.
• W1965372015 hasConcept C526805850 @default.
• W1965372015 hasConcept C71924100 @default.
• W1965372015 hasConcept C90924648 @default.
• W1965372015 hasConceptScore W1965372015C121608353 @default.
• W1965372015 hasConceptScore W1965372015C126322002 @default.
• W1965372015 hasConceptScore W1965372015C141071460 @default.

• next