Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965391089> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1965391089 endingPage "42" @default.
- W1965391089 startingPage "39" @default.
- W1965391089 abstract "Physicians treating hydatidiform mole are still seeking means of identifying those patients who will require chemotherapy. The standard accepted method is to follow human chorionic gonadotropin levels but CA-125 measurement has been suggested as a supplement that may be clinically useful. This study was undertaken to validate or refute the one previous study that addresses this issue. CA-125 was measured at the time of hydatidiform mole evacuation to determine (1) whether it would predict the need for chemotherapy and (2) whether it correlated with human chorionic gonadotropin and tumor load in following patients with hydatidiform mole and metastatic gestational trophoblastic disease.CA-125 was measured in serial weekly samples selected from diagnostic groups of patients with trophoblastic disease. Sixteen patients had hydatidiform mole with spontaneous resolution, fourteen had nonmetastatic gestational trophoblastic tumor, and four had low-risk metastatic disease. Six patients had high-risk metastatic disease. Ten patients had partial hydatidiform mole and one of these required chemotherapy. One patient had primary ovarian choriocarcinoma and three had placental site tumor.The mean preevacuation CA-125 among the 15 patients with complete hydatidiform mole was 40.9 U/ml: 52.5 U/ml for 5 patients who required chemotherapy and 36.2 U/ml for 10 patients who did not require chemotherapy. There was no statistical difference between these values. There was no correlation of CA-125 with hCG. Frequently CA-125 became negative when hCG was still elevated. Among six patients with high-risk disease, CA-125 was elevated in four but in all six patients hCG remained elevated when CA-125 became negative. In nine patients with partial hydatidiform mole CA-125 was elevated prior to mole evacuation and then became negative. The patient with a tetraploid conceptus who required chemotherapy had negative CA-125. With placental site tumor CA-125 was negative, but it was elevated with ovarian choriocarcinoma.CA-125 levels do not provide reliable information in the management of patients with gestational trophoblastic disease." @default.
- W1965391089 created "2016-06-24" @default.
- W1965391089 creator A5081276373 @default.
- W1965391089 date "2000-07-01" @default.
- W1965391089 modified "2023-09-23" @default.
- W1965391089 title "Measurement of CA-125 in Trophoblastic Disease" @default.
- W1965391089 cites W1610439870 @default.
- W1965391089 cites W1970275459 @default.
- W1965391089 cites W2030715776 @default.
- W1965391089 cites W2074064502 @default.
- W1965391089 cites W2090541153 @default.
- W1965391089 doi "https://doi.org/10.1006/gyno.2000.5823" @default.
- W1965391089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10873407" @default.
- W1965391089 hasPublicationYear "2000" @default.
- W1965391089 type Work @default.
- W1965391089 sameAs 1965391089 @default.
- W1965391089 citedByCount "5" @default.
- W1965391089 countsByYear W19653910892013 @default.
- W1965391089 countsByYear W19653910892014 @default.
- W1965391089 countsByYear W19653910892023 @default.
- W1965391089 crossrefType "journal-article" @default.
- W1965391089 hasAuthorship W1965391089A5081276373 @default.
- W1965391089 hasConcept C124815738 @default.
- W1965391089 hasConcept C126322002 @default.
- W1965391089 hasConcept C131872663 @default.
- W1965391089 hasConcept C172680121 @default.
- W1965391089 hasConcept C2775948956 @default.
- W1965391089 hasConcept C2776571570 @default.
- W1965391089 hasConcept C2776694085 @default.
- W1965391089 hasConcept C2776953305 @default.
- W1965391089 hasConcept C2778383414 @default.
- W1965391089 hasConcept C2778489058 @default.
- W1965391089 hasConcept C2778782382 @default.
- W1965391089 hasConcept C2779134260 @default.
- W1965391089 hasConcept C2779234561 @default.
- W1965391089 hasConcept C2780572646 @default.
- W1965391089 hasConcept C2780832733 @default.
- W1965391089 hasConcept C2908941940 @default.
- W1965391089 hasConcept C2909081632 @default.
- W1965391089 hasConcept C29456083 @default.
- W1965391089 hasConcept C46973012 @default.
- W1965391089 hasConcept C54355233 @default.
- W1965391089 hasConcept C71315377 @default.
- W1965391089 hasConcept C71924100 @default.
- W1965391089 hasConcept C86803240 @default.
- W1965391089 hasConcept C90924648 @default.
- W1965391089 hasConceptScore W1965391089C124815738 @default.
- W1965391089 hasConceptScore W1965391089C126322002 @default.
- W1965391089 hasConceptScore W1965391089C131872663 @default.
- W1965391089 hasConceptScore W1965391089C172680121 @default.
- W1965391089 hasConceptScore W1965391089C2775948956 @default.
- W1965391089 hasConceptScore W1965391089C2776571570 @default.
- W1965391089 hasConceptScore W1965391089C2776694085 @default.
- W1965391089 hasConceptScore W1965391089C2776953305 @default.
- W1965391089 hasConceptScore W1965391089C2778383414 @default.
- W1965391089 hasConceptScore W1965391089C2778489058 @default.
- W1965391089 hasConceptScore W1965391089C2778782382 @default.
- W1965391089 hasConceptScore W1965391089C2779134260 @default.
- W1965391089 hasConceptScore W1965391089C2779234561 @default.
- W1965391089 hasConceptScore W1965391089C2780572646 @default.
- W1965391089 hasConceptScore W1965391089C2780832733 @default.
- W1965391089 hasConceptScore W1965391089C2908941940 @default.
- W1965391089 hasConceptScore W1965391089C2909081632 @default.
- W1965391089 hasConceptScore W1965391089C29456083 @default.
- W1965391089 hasConceptScore W1965391089C46973012 @default.
- W1965391089 hasConceptScore W1965391089C54355233 @default.
- W1965391089 hasConceptScore W1965391089C71315377 @default.
- W1965391089 hasConceptScore W1965391089C71924100 @default.
- W1965391089 hasConceptScore W1965391089C86803240 @default.
- W1965391089 hasConceptScore W1965391089C90924648 @default.
- W1965391089 hasIssue "1" @default.
- W1965391089 hasLocation W19653910891 @default.
- W1965391089 hasLocation W19653910892 @default.
- W1965391089 hasOpenAccess W1965391089 @default.
- W1965391089 hasPrimaryLocation W19653910891 @default.
- W1965391089 hasRelatedWork W1965391089 @default.
- W1965391089 hasRelatedWork W1974396218 @default.
- W1965391089 hasRelatedWork W2007493862 @default.
- W1965391089 hasRelatedWork W2018681870 @default.
- W1965391089 hasRelatedWork W2106572315 @default.
- W1965391089 hasRelatedWork W2770657147 @default.
- W1965391089 hasRelatedWork W3121124333 @default.
- W1965391089 hasRelatedWork W33686792 @default.
- W1965391089 hasRelatedWork W4313353361 @default.
- W1965391089 hasRelatedWork W962811501 @default.
- W1965391089 hasVolume "78" @default.
- W1965391089 isParatext "false" @default.
- W1965391089 isRetracted "false" @default.
- W1965391089 magId "1965391089" @default.
- W1965391089 workType "article" @default.