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• W1965402974 abstract "BackgroundAcinar cell carcinoma (ACC) is a rare pancreatic neoplasm, representing 1% of exocrine tumours and containing a variable endocrine component. Three recent cases of ACC are reported.Case outlinesA 72‐year‐old man with painless obstructive jaundice had a 5‐cm mass in the head of pancreas resected by Whipple's operation; histopathological examination showed a typical ACC. A 33‐year‐old man with weight loss and abnormal liver function had a dilated biliary tree but no mass on imaging. Pylorus‐preserving pancreatoduodenectomy was performed, and histology showed a mixed acinar‐neuroendocrine tumour. A 56‐year‐old man with weight loss and a palpable mass had a 15‐cm mass in the distal body of pancreas, which was resected en bloc with the spleen and adherent stomach; it was a cystic ACC.ResultsTwo patients are alive and free of disease at 30 months and 15 months, while the third patient with locally advanced disease died of myocardial infarction at 9 weeks.DiscussionAcinar structures are the hallmark of this neoplasm, which carries a better survival rate than ductal cancer. Surgical excision prolongs survival and offers the best chance of cure. Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm, representing 1% of exocrine tumours and containing a variable endocrine component. Three recent cases of ACC are reported. A 72‐year‐old man with painless obstructive jaundice had a 5‐cm mass in the head of pancreas resected by Whipple's operation; histopathological examination showed a typical ACC. A 33‐year‐old man with weight loss and abnormal liver function had a dilated biliary tree but no mass on imaging. Pylorus‐preserving pancreatoduodenectomy was performed, and histology showed a mixed acinar‐neuroendocrine tumour. A 56‐year‐old man with weight loss and a palpable mass had a 15‐cm mass in the distal body of pancreas, which was resected en bloc with the spleen and adherent stomach; it was a cystic ACC. Two patients are alive and free of disease at 30 months and 15 months, while the third patient with locally advanced disease died of myocardial infarction at 9 weeks. Acinar structures are the hallmark of this neoplasm, which carries a better survival rate than ductal cancer. Surgical excision prolongs survival and offers the best chance of cure." @default.
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• W1965402974 date "2002-06-01" @default.
• W1965402974 modified "2023-09-26" @default.
• W1965402974 title "Acinar cell carcinoma of the pancreas with and without endocrine differentiation" @default.
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• W1965402974 doi "https://doi.org/10.1080/136518202760378452" @default.
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