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• W1965407048 endingPage "2804" @default.
• W1965407048 startingPage "2796" @default.
• W1965407048 abstract "The peroxidase-oxidase reaction is known to involve reactive oxygen species as intermediates. These intermediates inactivate many types of biomolecules, including peroxidase itself. Previously, we have shown that oscillatory dynamics in the peroxidase-oxidase reaction seem to protect the enzyme from inactivation. It was suggested that this is due to a lower average concentration of reactive oxygen species in the oscillatory state compared to the steady state. Here, we studied the peroxidase-oxidase reaction with either 4-hydroxybenzoic acid or melatonin as cofactors. We show that the protective effect of oscillatory dynamics is present in both cases. We also found that the enzyme degradation depends on the concentration of the cofactor and on the pH of the reaction mixture. We simulated the oscillatory behaviour, including the oscillation/steady state bistability observed experimentally, using a detailed reaction scheme. The computational results confirm the hypothesis that protection is due to lower average concentrations of superoxide radical during oscillations. They also show that the shape of the oscillations changes with increasing cofactor concentration resulting in a further decrease in the average concentration of radicals. We therefore hypothesize that the protective effect of oscillatory dynamics is a general effect in this system." @default.
• W1965407048 created "2016-06-24" @default.
• W1965407048 creator A5036398559 @default.
• W1965407048 creator A5067727401 @default.
• W1965407048 creator A5068328382 @default.
• W1965407048 date "2003-07-01" @default.
• W1965407048 modified "2023-10-16" @default.
• W1965407048 title "Mechanism of protection of peroxidase activity by oscillatory dynamics" @default.
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• W1965407048 doi "https://doi.org/10.1046/j.1432-1033.2003.03655.x" @default.
• W1965407048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12823550" @default.
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