FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965431331> ?p ?o ?g. }

• W1965431331 endingPage "1235" @default.
• W1965431331 startingPage "1227" @default.
• W1965431331 abstract "The packing structures of transmembrane helices are traditionally attributed to patterns in residues along the contact surface. In this view, besides keeping the helices confined in the membrane, the bilayer has only a minor effect on the helices structure. Here, we use two different approaches to show that the lipid environment has a crucial effect in determining the cross-angle distribution of packed helices. We analyzed structural data of a membrane proteins database. We show that the distribution of cross angles of helix pairs in this database is statistically indistinguishable from the cross-angle distribution of two noninteracting helices imbedded in the membrane. These results suggest that the cross angle is, to a large extent, determined by the tilt angle of the individual helices. We test this hypothesis using molecular simulations of a coarse-grained model that contains no specific residue interactions. These simulations reproduce the same cross-angle distribution as found in the database. As the tilt angle of a helix is dominated by hydrophobic mismatch between the protein and surrounding lipids, our results indicate that hydrophobic mismatch is the dominant factor guiding the transmembrane helix packing. Other short-range forces might then fine-tune the structure to its final configuration." @default.
• W1965431331 created "2016-06-24" @default.
• W1965431331 creator A5039832669 @default.
• W1965431331 creator A5075317126 @default.
• W1965431331 date "2012-09-01" @default.
• W1965431331 modified "2023-10-06" @default.
• W1965431331 title "Robust Driving Forces for Transmembrane Helix Packing" @default.
• W1965431331 cites W1519714250 @default.
• W1965431331 cites W1966309781 @default.
• W1965431331 cites W1967383045 @default.
• W1965431331 cites W1970543598 @default.
• W1965431331 cites W1970605146 @default.
• W1965431331 cites W1973208468 @default.
• W1965431331 cites W1975304761 @default.
• W1965431331 cites W1989355568 @default.
• W1965431331 cites W1993418953 @default.
• W1965431331 cites W1999420570 @default.
• W1965431331 cites W2008708467 @default.
• W1965431331 cites W2013652494 @default.
• W1965431331 cites W2013850102 @default.
• W1965431331 cites W2023559429 @default.
• W1965431331 cites W2026863841 @default.
• W1965431331 cites W2027711565 @default.
• W1965431331 cites W2028203188 @default.
• W1965431331 cites W2029258147 @default.
• W1965431331 cites W2029653438 @default.
• W1965431331 cites W2030947664 @default.
• W1965431331 cites W2032655419 @default.
• W1965431331 cites W2040255016 @default.
• W1965431331 cites W2051425608 @default.
• W1965431331 cites W2051864856 @default.
• W1965431331 cites W2053747306 @default.
• W1965431331 cites W2059625238 @default.
• W1965431331 cites W2061888384 @default.
• W1965431331 cites W2064506623 @default.
• W1965431331 cites W2074362388 @default.
• W1965431331 cites W2074437547 @default.
• W1965431331 cites W2076444761 @default.
• W1965431331 cites W2080301705 @default.
• W1965431331 cites W2081030911 @default.
• W1965431331 cites W2082102819 @default.
• W1965431331 cites W2083336183 @default.
• W1965431331 cites W2086799757 @default.
• W1965431331 cites W2093386916 @default.
• W1965431331 cites W2097775366 @default.
• W1965431331 cites W2099347401 @default.
• W1965431331 cites W2101934167 @default.
• W1965431331 cites W2116441099 @default.
• W1965431331 cites W2123871914 @default.
• W1965431331 cites W2134418610 @default.
• W1965431331 cites W2134905807 @default.
• W1965431331 cites W2135765179 @default.
• W1965431331 cites W2142579286 @default.
• W1965431331 cites W2145020089 @default.
• W1965431331 cites W2148724380 @default.
• W1965431331 cites W2156360597 @default.
• W1965431331 cites W2156835500 @default.
• W1965431331 cites W2169210766 @default.
• W1965431331 cites W2170711116 @default.
• W1965431331 cites W2790579675 @default.
• W1965431331 cites W4298850410 @default.
• W1965431331 doi "https://doi.org/10.1016/j.bpj.2012.08.035" @default.
• W1965431331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3446696" @default.
• W1965431331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22995495" @default.
• W1965431331 hasPublicationYear "2012" @default.
• W1965431331 type Work @default.
• W1965431331 sameAs 1965431331 @default.
• W1965431331 citedByCount "24" @default.
• W1965431331 countsByYear W19654313312012 @default.
• W1965431331 countsByYear W19654313312013 @default.
• W1965431331 countsByYear W19654313312014 @default.
• W1965431331 countsByYear W19654313312015 @default.
• W1965431331 countsByYear W19654313312016 @default.
• W1965431331 countsByYear W19654313312022 @default.
• W1965431331 crossrefType "journal-article" @default.
• W1965431331 hasAuthorship W1965431331A5039832669 @default.
• W1965431331 hasAuthorship W1965431331A5075317126 @default.
• W1965431331 hasBestOaLocation W19654313311 @default.
• W1965431331 hasConcept C118892022 @default.
• W1965431331 hasConcept C12554922 @default.
• W1965431331 hasConcept C144647389 @default.
• W1965431331 hasConcept C147597530 @default.
• W1965431331 hasConcept C159467904 @default.
• W1965431331 hasConcept C170493617 @default.
• W1965431331 hasConcept C185592680 @default.
• W1965431331 hasConcept C18903297 @default.
• W1965431331 hasConcept C192157962 @default.
• W1965431331 hasConcept C24530287 @default.
• W1965431331 hasConcept C2524010 @default.
• W1965431331 hasConcept C2778530040 @default.
• W1965431331 hasConcept C2779844322 @default.
• W1965431331 hasConcept C2779965526 @default.
• W1965431331 hasConcept C33923547 @default.
• W1965431331 hasConcept C39944091 @default.
• W1965431331 hasConcept C41625074 @default.
• W1965431331 hasConcept C47701112 @default.
• W1965431331 hasConcept C55493867 @default.
• W1965431331 hasConcept C59593255 @default.

• next