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- W1965445423 abstract "To assess the effectiveness of combined therapy with azlocillin and amikacin in a group of neonates with sepsis caused by multiresistant staphylococci who were hospitalized in the neonatal intensive care unit of Hospital Ginecobstétrico America Arias in Havana, Cuba, from 1998 to 2000.A retrospective study was carried out of the clinical and laboratory results obtained in 15 patients with sepsis caused by multiresistant staphylococci who received combined therapy with azlocillin and amikacin, according to hospital guidelines on the use of antibiotics. We used a broth microdilution method to study the patterns of resistance shown by isolated strains to 10 of the antibiotics in use. In vitro synergy tests, specifically the checkerboard technique with microtitration plates, were used to observe the effects of treatment in 8 patients.Twelve coagulase-negative staphylococci and three Staphylococcus aureus isolates showed five different patterns of resistance on the basis of their sensitivity to oxacillin, three aminoglycosides, and vancomycin. Six of the synergy tests showed a considerable synergistic effect, with an average three-fold reduction in the minimum inhibitory concentrations (MIC) of the two antibiotics used to treat the patients. No antagonistic effects were noted, and the combined antibiotics showed an overall clinical effectiveness of 91.7%.The test showed that the therapeutic combination used was effective, but further studies are needed before conclusive results are obtained." @default.
- W1965445423 created "2016-06-24" @default.
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- W1965445423 date "2004-11-01" @default.
- W1965445423 modified "2023-09-23" @default.
- W1965445423 title "Azlocilina y amikacina: ¿una alternativa terapéutica para la septicemia por estafilococos resistentes?" @default.
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- W1965445423 doi "https://doi.org/10.1590/s1020-49892004001100004" @default.
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