FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965446630> ?p ?o ?g. }

• W1965446630 endingPage "140" @default.
• W1965446630 startingPage "132" @default.
• W1965446630 abstract "A correlation exists between the absence of alpha5-laminin and transit checkpoint fenestrations in vascular basement membranes. We hypothesized that similar laminin alpha5 low expression regions might exist in synovial lining, which, although lacking basement membrane, contains all basement membrane components in its interstitial matrix.Laminin alpha4 and alpha5 chains and lactoferrin were stained using immunofluorescence and cathepsin G and neutrophil elastase using immunoperoxidase. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure laminin alpha4 and alpha5 mRNA copy numbers in cultured synovial fibroblasts, without/with tumour necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta).Laminin alpha4 and alpha5 chains were found in the intercellular matrix in synovial lining samples of trauma and revision total hip replacements. Laminin alpha5 was weaker in osteoarthritis (OA) and rheumatoid arthritis (RA), and RA synovial lining also contained local low expression areas. Double staining disclosed convergence of lactoferrin-degranulating neutrophils towards these laminin alpha5 low expression regions. In cultured OA synovial fibroblasts, laminin alpha5 mRNA decreased (p < 0.05) at 1 ng/mL TNFalpha and was not found at all in cultured resting or cytokine-stimulated RA fibroblasts. Degranulation of cathepsin G and neutrophil elastase was seen in neutrophils passing through blood vessels or synovial lining.Migrating neutrophils in RA seem to use laminin alpha5 chain low expression regions to exit synovial tissue to enter synovial fluid. Transmigrating neutrophils remodel the intercellular matrix by releasing their proteolytic granular contents to enhance these low expression checkpoints and/or to produce chemotactic stimuli. In RA fibroblasts this is facilitated by cytokine-mediated down-regulation or lack of laminin alpha5 synthesis." @default.
• W1965446630 created "2016-06-24" @default.
• W1965446630 creator A5022218689 @default.
• W1965446630 creator A5024479701 @default.
• W1965446630 creator A5025972377 @default.
• W1965446630 creator A5050963625 @default.
• W1965446630 creator A5062239978 @default.
• W1965446630 date "2010-01-08" @default.
• W1965446630 modified "2023-09-30" @default.
• W1965446630 title "Immigration check for neutrophils in RA lining: laminin α5 low expression regions act as exit points" @default.
• W1965446630 cites W1518604518 @default.
• W1965446630 cites W1540327780 @default.
• W1965446630 cites W1870510950 @default.
• W1965446630 cites W1967470122 @default.
• W1965446630 cites W1968549998 @default.
• W1965446630 cites W1970443937 @default.
• W1965446630 cites W1976242517 @default.
• W1965446630 cites W1976833987 @default.
• W1965446630 cites W1978018593 @default.
• W1965446630 cites W1988808523 @default.
• W1965446630 cites W2016077190 @default.
• W1965446630 cites W2022550539 @default.
• W1965446630 cites W2033142287 @default.
• W1965446630 cites W2033821478 @default.
• W1965446630 cites W2047710667 @default.
• W1965446630 cites W2048559590 @default.
• W1965446630 cites W2049787898 @default.
• W1965446630 cites W2076960137 @default.
• W1965446630 cites W2085408539 @default.
• W1965446630 cites W2089747862 @default.
• W1965446630 cites W2093446277 @default.
• W1965446630 cites W2093719004 @default.
• W1965446630 cites W2097264743 @default.
• W1965446630 cites W2113155612 @default.
• W1965446630 cites W2118510088 @default.
• W1965446630 cites W2133692536 @default.
• W1965446630 cites W2137339420 @default.
• W1965446630 cites W2138919048 @default.
• W1965446630 cites W2139582968 @default.
• W1965446630 cites W2149970650 @default.
• W1965446630 cites W2152029916 @default.
• W1965446630 cites W2152765608 @default.
• W1965446630 cites W2154344438 @default.
• W1965446630 cites W2166703723 @default.
• W1965446630 cites W2167800322 @default.
• W1965446630 cites W2343428206 @default.
• W1965446630 cites W4214589643 @default.
• W1965446630 cites W4229959038 @default.
• W1965446630 cites W4238295192 @default.
• W1965446630 cites W4379136709 @default.
• W1965446630 doi "https://doi.org/10.3109/03009740903198980" @default.
• W1965446630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20059371" @default.
• W1965446630 hasPublicationYear "2010" @default.
• W1965446630 type Work @default.
• W1965446630 sameAs 1965446630 @default.
• W1965446630 citedByCount "6" @default.
• W1965446630 countsByYear W19654466302012 @default.
• W1965446630 countsByYear W19654466302022 @default.
• W1965446630 countsByYear W19654466302023 @default.
• W1965446630 crossrefType "journal-article" @default.
• W1965446630 hasAuthorship W1965446630A5022218689 @default.
• W1965446630 hasAuthorship W1965446630A5024479701 @default.
• W1965446630 hasAuthorship W1965446630A5025972377 @default.
• W1965446630 hasAuthorship W1965446630A5050963625 @default.
• W1965446630 hasAuthorship W1965446630A5062239978 @default.
• W1965446630 hasConcept C142724271 @default.
• W1965446630 hasConcept C153911025 @default.
• W1965446630 hasConcept C189165786 @default.
• W1965446630 hasConcept C203014093 @default.
• W1965446630 hasConcept C2776193487 @default.
• W1965446630 hasConcept C2776317360 @default.
• W1965446630 hasConcept C2776914184 @default.
• W1965446630 hasConcept C2777652487 @default.
• W1965446630 hasConcept C2779170986 @default.
• W1965446630 hasConcept C2779814568 @default.
• W1965446630 hasConcept C55493867 @default.
• W1965446630 hasConcept C71924100 @default.
• W1965446630 hasConcept C86492073 @default.
• W1965446630 hasConcept C86803240 @default.
• W1965446630 hasConcept C95444343 @default.
• W1965446630 hasConceptScore W1965446630C142724271 @default.
• W1965446630 hasConceptScore W1965446630C153911025 @default.
• W1965446630 hasConceptScore W1965446630C189165786 @default.
• W1965446630 hasConceptScore W1965446630C203014093 @default.
• W1965446630 hasConceptScore W1965446630C2776193487 @default.
• W1965446630 hasConceptScore W1965446630C2776317360 @default.
• W1965446630 hasConceptScore W1965446630C2776914184 @default.
• W1965446630 hasConceptScore W1965446630C2777652487 @default.
• W1965446630 hasConceptScore W1965446630C2779170986 @default.
• W1965446630 hasConceptScore W1965446630C2779814568 @default.
• W1965446630 hasConceptScore W1965446630C55493867 @default.
• W1965446630 hasConceptScore W1965446630C71924100 @default.
• W1965446630 hasConceptScore W1965446630C86492073 @default.
• W1965446630 hasConceptScore W1965446630C86803240 @default.
• W1965446630 hasConceptScore W1965446630C95444343 @default.
• W1965446630 hasIssue "2" @default.
• W1965446630 hasLocation W19654466301 @default.
• W1965446630 hasLocation W19654466302 @default.

• next