Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965446739> ?p ?o ?g. }
- W1965446739 endingPage "1329" @default.
- W1965446739 startingPage "1315" @default.
- W1965446739 abstract "The survival and growth of squamous epithelial cells require signals generated by integrin-matrix interactions. After conversion to squamous cell carcinoma, the cells remain sensitive to detachment-induced anoikis, yet in tumor cell aggregates, which are matrix-deficient, these cells are capable of suprabasal survival and proliferation. Their survival is enhanced through a process we call synoikis, whereby junctional adhesions between neighboring cells generate specific downstream survival signals. Here we show that in squamous cell carcinoma cells, E-cadherin-mediated cell-cell contacts specifically induce activation of epidermal growth factor receptor (EGFR). EGFR activation in turn triggers the ERK/MAPK signaling module, leading to elevation of anti-apoptotic Bcl-2. After intercellular adhesion, formation of adherens junctions triggers the formation of E-cadherin-EGFR complexes, correlating with EGFR transactivation. Analysis of the process with a dominant-negative EGFR mutant indicated that activation of EGFR is ligand-independent. Our data implicate cell-cell adhesion-induced activation of EGFR as a cooperative mechanism that generates compensatory survival signaling, protecting malignant cells from detachment-induced death." @default.
- W1965446739 created "2016-06-24" @default.
- W1965446739 creator A5027631631 @default.
- W1965446739 creator A5086309026 @default.
- W1965446739 date "2004-10-01" @default.
- W1965446739 modified "2023-10-03" @default.
- W1965446739 title "Adhesion-Mediated Squamous Cell Carcinoma Survival through Ligand-Independent Activation of Epidermal Growth Factor Receptor" @default.
- W1965446739 cites W115812004 @default.
- W1965446739 cites W1967532587 @default.
- W1965446739 cites W1976971341 @default.
- W1965446739 cites W1981393628 @default.
- W1965446739 cites W1983072511 @default.
- W1965446739 cites W1983821491 @default.
- W1965446739 cites W1986402843 @default.
- W1965446739 cites W1986490038 @default.
- W1965446739 cites W1988064309 @default.
- W1965446739 cites W1992706018 @default.
- W1965446739 cites W1995819749 @default.
- W1965446739 cites W2000552194 @default.
- W1965446739 cites W2000707284 @default.
- W1965446739 cites W2001155346 @default.
- W1965446739 cites W2002885378 @default.
- W1965446739 cites W2004408045 @default.
- W1965446739 cites W2007572328 @default.
- W1965446739 cites W2015314629 @default.
- W1965446739 cites W2018847450 @default.
- W1965446739 cites W2021401761 @default.
- W1965446739 cites W2024651104 @default.
- W1965446739 cites W2027613471 @default.
- W1965446739 cites W2029039474 @default.
- W1965446739 cites W2030735294 @default.
- W1965446739 cites W2035967893 @default.
- W1965446739 cites W2038882649 @default.
- W1965446739 cites W2040865177 @default.
- W1965446739 cites W2041043194 @default.
- W1965446739 cites W2045455054 @default.
- W1965446739 cites W2047437874 @default.
- W1965446739 cites W2049793641 @default.
- W1965446739 cites W2053951755 @default.
- W1965446739 cites W2056593572 @default.
- W1965446739 cites W2057022330 @default.
- W1965446739 cites W2058085176 @default.
- W1965446739 cites W2058839845 @default.
- W1965446739 cites W2060208069 @default.
- W1965446739 cites W2064538929 @default.
- W1965446739 cites W2067447488 @default.
- W1965446739 cites W2075004606 @default.
- W1965446739 cites W2082952854 @default.
- W1965446739 cites W2089344215 @default.
- W1965446739 cites W2093024420 @default.
- W1965446739 cites W2102369096 @default.
- W1965446739 cites W2110358014 @default.
- W1965446739 cites W2114354954 @default.
- W1965446739 cites W2114646523 @default.
- W1965446739 cites W2121627701 @default.
- W1965446739 cites W2122829982 @default.
- W1965446739 cites W2128810146 @default.
- W1965446739 cites W2137022580 @default.
- W1965446739 cites W2140151933 @default.
- W1965446739 cites W2144209351 @default.
- W1965446739 cites W2147114673 @default.
- W1965446739 cites W2154553662 @default.
- W1965446739 cites W2160926271 @default.
- W1965446739 cites W2326572877 @default.
- W1965446739 cites W2435167068 @default.
- W1965446739 cites W4232995978 @default.
- W1965446739 cites W4243385699 @default.
- W1965446739 doi "https://doi.org/10.1016/s0002-9440(10)63390-1" @default.
- W1965446739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1618631" @default.
- W1965446739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15466396" @default.
- W1965446739 hasPublicationYear "2004" @default.
- W1965446739 type Work @default.
- W1965446739 sameAs 1965446739 @default.
- W1965446739 citedByCount "116" @default.
- W1965446739 countsByYear W19654467392012 @default.
- W1965446739 countsByYear W19654467392013 @default.
- W1965446739 countsByYear W19654467392014 @default.
- W1965446739 countsByYear W19654467392015 @default.
- W1965446739 countsByYear W19654467392016 @default.
- W1965446739 countsByYear W19654467392017 @default.
- W1965446739 countsByYear W19654467392018 @default.
- W1965446739 countsByYear W19654467392019 @default.
- W1965446739 countsByYear W19654467392020 @default.
- W1965446739 countsByYear W19654467392021 @default.
- W1965446739 countsByYear W19654467392022 @default.
- W1965446739 countsByYear W19654467392023 @default.
- W1965446739 crossrefType "journal-article" @default.
- W1965446739 hasAuthorship W1965446739A5027631631 @default.
- W1965446739 hasAuthorship W1965446739A5086309026 @default.
- W1965446739 hasBestOaLocation W19654467392 @default.
- W1965446739 hasConcept C1491633281 @default.
- W1965446739 hasConcept C149402561 @default.
- W1965446739 hasConcept C152000582 @default.
- W1965446739 hasConcept C170493617 @default.
- W1965446739 hasConcept C190283241 @default.
- W1965446739 hasConcept C201508349 @default.
- W1965446739 hasConcept C2776362946 @default.
- W1965446739 hasConcept C2779438470 @default.