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- W1965448712 abstract "Novel 16,17- seco -naltrexone derivatives 3 were synthesized using 16–17 bond cleavage reaction of naltrexone as the key reaction to examine the Beckett–Casy model. Novel 16,17- seco -naltrexone derivatives 3 were synthesized using a 16–17 bond cleavage reaction of naltrexone as the key reaction to examine the Beckett–Casy model. All the prepared 16,17- seco -naltrexone derivatives 3 showed lower affinities for opioid receptors than naltrexone. Although the results of binding assay seem to support the existence of a cavity in the model, further investigation using 15,16-nornaltrexone derivatives 26 will be needed to confirm the model." @default.
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- W1965448712 date "2010-02-01" @default.
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- W1965448712 title "Investigation of Beckett–Casy model 1: Synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology" @default.
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- W1965448712 doi "https://doi.org/10.1016/j.bmcl.2009.12.039" @default.
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