Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965465229> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1965465229 endingPage "21" @default.
- W1965465229 startingPage "17" @default.
- W1965465229 abstract "An antiidiotypic/clonotypic marker, designated 1F7, is restricted to antibodies directed to human immunodeficiency virus type 1 (HIV-1) envelope, core, and reverse transcriptase proteins. 1F7-Id is shared by more than 70% of HIV-infected individuals, arising early and persisting throughout all disease stages. To study the specificity and biological function of this cross-reactive idiotypic marker, and to explore its potential in therapeutics, we have sought an appropriate animal model. 1F7-Id+ antiviral antibodies are found among experimentally HIV-1 IIIB-infected chimpanzees; however, these rare and expensive animals do not develop acquired immunodeficiency syndrome (AIDS), and so are not an appropriate model. We now report the presence in rhesus monkeys of 1F7-Id on antibodies to the external envelope glycoproteins of simian immunodeficiency virus (SIV). This may be surprising, in view of the genetic and serologic differences between SIV and HIV-1, but is in accord with the occurrence of 1F7-Id on antibodies reacting with a broad range of HIV-1 strains. We also found 1F7-Id on anti-gp120 antibodies in rhesus monkeys infected with chimeric immunodeficiency viruses (SHIV) expressing the env, tat, and rev genes of HIV-1 on a backbone of SIV. Both SIV and SHIV cause AIDS in these monkeys. Thus, SIV- and SHIV-infected rhesus monkeys are suitable models for exploring the role of 1F7 in AIDS pathogenesis and prevention. Experiments are underway using MAb 1F7 to test the hypothesis of deceptive imprinting in AIDS." @default.
- W1965465229 created "2016-06-24" @default.
- W1965465229 creator A5018515110 @default.
- W1965465229 creator A5024227929 @default.
- W1965465229 creator A5069727178 @default.
- W1965465229 date "1997-02-01" @default.
- W1965465229 modified "2023-10-16" @default.
- W1965465229 title "An HIV-1 Infection-Related Idiotype/Clonotype (1F7) Is Expressed on Antibodies Directed to Envelope Glycoprotein in Simian Immunodeficiency Virus- and Chimeric Simian/Human Immunodeficiency Virus-Infected Rhesus Monkeys" @default.
- W1965465229 cites W1571431813 @default.
- W1965465229 cites W1576742764 @default.
- W1965465229 cites W1586476245 @default.
- W1965465229 cites W1820808323 @default.
- W1965465229 cites W1837018648 @default.
- W1965465229 cites W1946734657 @default.
- W1965465229 cites W1965359767 @default.
- W1965465229 cites W2007644904 @default.
- W1965465229 cites W2013589453 @default.
- W1965465229 cites W2016906277 @default.
- W1965465229 cites W2032790020 @default.
- W1965465229 cites W2041213253 @default.
- W1965465229 cites W2041815393 @default.
- W1965465229 cites W2045777528 @default.
- W1965465229 cites W2053885475 @default.
- W1965465229 cites W2067237014 @default.
- W1965465229 cites W2091559213 @default.
- W1965465229 cites W2127291045 @default.
- W1965465229 cites W2164317596 @default.
- W1965465229 doi "https://doi.org/10.1089/hyb.1997.16.17" @default.
- W1965465229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9085123" @default.
- W1965465229 hasPublicationYear "1997" @default.
- W1965465229 type Work @default.
- W1965465229 sameAs 1965465229 @default.
- W1965465229 citedByCount "12" @default.
- W1965465229 countsByYear W19654652292013 @default.
- W1965465229 countsByYear W19654652292014 @default.
- W1965465229 countsByYear W19654652292016 @default.
- W1965465229 countsByYear W19654652292022 @default.
- W1965465229 crossrefType "journal-article" @default.
- W1965465229 hasAuthorship W1965465229A5018515110 @default.
- W1965465229 hasAuthorship W1965465229A5024227929 @default.
- W1965465229 hasAuthorship W1965465229A5069727178 @default.
- W1965465229 hasConcept C108625454 @default.
- W1965465229 hasConcept C159047783 @default.
- W1965465229 hasConcept C159654299 @default.
- W1965465229 hasConcept C203014093 @default.
- W1965465229 hasConcept C2522874641 @default.
- W1965465229 hasConcept C2777607303 @default.
- W1965465229 hasConcept C2777995582 @default.
- W1965465229 hasConcept C2779690655 @default.
- W1965465229 hasConcept C2780727368 @default.
- W1965465229 hasConcept C45189115 @default.
- W1965465229 hasConcept C542903549 @default.
- W1965465229 hasConcept C54355233 @default.
- W1965465229 hasConcept C74505204 @default.
- W1965465229 hasConcept C86803240 @default.
- W1965465229 hasConcept C8891405 @default.
- W1965465229 hasConcept C97380033 @default.
- W1965465229 hasConceptScore W1965465229C108625454 @default.
- W1965465229 hasConceptScore W1965465229C159047783 @default.
- W1965465229 hasConceptScore W1965465229C159654299 @default.
- W1965465229 hasConceptScore W1965465229C203014093 @default.
- W1965465229 hasConceptScore W1965465229C2522874641 @default.
- W1965465229 hasConceptScore W1965465229C2777607303 @default.
- W1965465229 hasConceptScore W1965465229C2777995582 @default.
- W1965465229 hasConceptScore W1965465229C2779690655 @default.
- W1965465229 hasConceptScore W1965465229C2780727368 @default.
- W1965465229 hasConceptScore W1965465229C45189115 @default.
- W1965465229 hasConceptScore W1965465229C542903549 @default.
- W1965465229 hasConceptScore W1965465229C54355233 @default.
- W1965465229 hasConceptScore W1965465229C74505204 @default.
- W1965465229 hasConceptScore W1965465229C86803240 @default.
- W1965465229 hasConceptScore W1965465229C8891405 @default.
- W1965465229 hasConceptScore W1965465229C97380033 @default.
- W1965465229 hasIssue "1" @default.
- W1965465229 hasLocation W19654652291 @default.
- W1965465229 hasLocation W19654652292 @default.
- W1965465229 hasOpenAccess W1965465229 @default.
- W1965465229 hasPrimaryLocation W19654652291 @default.
- W1965465229 hasRelatedWork W1525771412 @default.
- W1965465229 hasRelatedWork W1586476245 @default.
- W1965465229 hasRelatedWork W1598451890 @default.
- W1965465229 hasRelatedWork W1919653978 @default.
- W1965465229 hasRelatedWork W1965465229 @default.
- W1965465229 hasRelatedWork W1969535318 @default.
- W1965465229 hasRelatedWork W2007481115 @default.
- W1965465229 hasRelatedWork W2053446190 @default.
- W1965465229 hasRelatedWork W2121098802 @default.
- W1965465229 hasRelatedWork W2245075643 @default.
- W1965465229 hasVolume "16" @default.
- W1965465229 isParatext "false" @default.
- W1965465229 isRetracted "false" @default.
- W1965465229 magId "1965465229" @default.
- W1965465229 workType "article" @default.