Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965467335> ?p ?o ?g. }
- W1965467335 endingPage "214" @default.
- W1965467335 startingPage "202" @default.
- W1965467335 abstract "Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a distinct disease rather than a subtype of multiple sclerosis. In NMO, serum antibodies, collectively known as NMO-IgG, characteristically bind to cerebral microvessels, pia mater and Virchow-Robin spaces. The main target antigen for this immunoreactivity has been identified as aquaporin-4 (AQP4). The antibodies are highly specific for NMO, and they are also found in patients with longitudinally extensive transverse myelitis without optic neuritis, which is thought to be a precursor to NMO in some cases. An antibody-mediated pathogenesis for NMO is supported by several observations, including the characteristics of the AQP4 antibodies, the distinct NMO pathology--which includes IgG and complement deposition and loss of AQP4 from spinal cord lesions--and emerging evidence of the beneficial effects of B-cell depletion and plasma exchange. Many aspects of the pathogenesis, however, remain unclear." @default.
- W1965467335 created "2016-06-24" @default.
- W1965467335 creator A5009280913 @default.
- W1965467335 creator A5011686938 @default.
- W1965467335 creator A5028689651 @default.
- W1965467335 creator A5038094544 @default.
- W1965467335 creator A5056912783 @default.
- W1965467335 creator A5062939642 @default.
- W1965467335 creator A5081462122 @default.
- W1965467335 creator A5083000991 @default.
- W1965467335 date "2008-03-11" @default.
- W1965467335 modified "2023-10-14" @default.
- W1965467335 title "Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica" @default.
- W1965467335 cites W1486269303 @default.
- W1965467335 cites W1495656315 @default.
- W1965467335 cites W1535419310 @default.
- W1965467335 cites W1561460904 @default.
- W1965467335 cites W1588005980 @default.
- W1965467335 cites W1593132420 @default.
- W1965467335 cites W1963614683 @default.
- W1965467335 cites W1970685254 @default.
- W1965467335 cites W1972774408 @default.
- W1965467335 cites W1977300079 @default.
- W1965467335 cites W1979488598 @default.
- W1965467335 cites W1980853756 @default.
- W1965467335 cites W1981601638 @default.
- W1965467335 cites W1982914364 @default.
- W1965467335 cites W1988296977 @default.
- W1965467335 cites W1990271301 @default.
- W1965467335 cites W1998029081 @default.
- W1965467335 cites W2004630293 @default.
- W1965467335 cites W2004973774 @default.
- W1965467335 cites W2007128839 @default.
- W1965467335 cites W2007654857 @default.
- W1965467335 cites W2009308901 @default.
- W1965467335 cites W2021554101 @default.
- W1965467335 cites W2026592520 @default.
- W1965467335 cites W2028844455 @default.
- W1965467335 cites W2028977155 @default.
- W1965467335 cites W2029012161 @default.
- W1965467335 cites W2030524649 @default.
- W1965467335 cites W2033063046 @default.
- W1965467335 cites W2033794046 @default.
- W1965467335 cites W2034612585 @default.
- W1965467335 cites W2036561925 @default.
- W1965467335 cites W2041331549 @default.
- W1965467335 cites W2042251435 @default.
- W1965467335 cites W2042300677 @default.
- W1965467335 cites W2048761373 @default.
- W1965467335 cites W2051760559 @default.
- W1965467335 cites W2053472907 @default.
- W1965467335 cites W2056788579 @default.
- W1965467335 cites W2061026694 @default.
- W1965467335 cites W2064541324 @default.
- W1965467335 cites W2067927161 @default.
- W1965467335 cites W2072150133 @default.
- W1965467335 cites W2073987596 @default.
- W1965467335 cites W2075614360 @default.
- W1965467335 cites W2079198633 @default.
- W1965467335 cites W2080148670 @default.
- W1965467335 cites W2080476124 @default.
- W1965467335 cites W2080572190 @default.
- W1965467335 cites W2081641090 @default.
- W1965467335 cites W2081840738 @default.
- W1965467335 cites W2082646193 @default.
- W1965467335 cites W2085393269 @default.
- W1965467335 cites W2089002261 @default.
- W1965467335 cites W2092066224 @default.
- W1965467335 cites W2092149677 @default.
- W1965467335 cites W2097299570 @default.
- W1965467335 cites W2099667986 @default.
- W1965467335 cites W2100232740 @default.
- W1965467335 cites W2104448214 @default.
- W1965467335 cites W2105722099 @default.
- W1965467335 cites W2105963284 @default.
- W1965467335 cites W2120238028 @default.
- W1965467335 cites W2124292468 @default.
- W1965467335 cites W2124376257 @default.
- W1965467335 cites W2124851812 @default.
- W1965467335 cites W2126145768 @default.
- W1965467335 cites W2126277063 @default.
- W1965467335 cites W2133934007 @default.
- W1965467335 cites W2136132690 @default.
- W1965467335 cites W2138427089 @default.
- W1965467335 cites W2144469764 @default.
- W1965467335 cites W2147062889 @default.
- W1965467335 cites W2150774332 @default.
- W1965467335 cites W2161681716 @default.
- W1965467335 cites W2164044035 @default.
- W1965467335 cites W2164731058 @default.
- W1965467335 cites W97069602 @default.
- W1965467335 doi "https://doi.org/10.1038/ncpneuro0764" @default.
- W1965467335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18334978" @default.
- W1965467335 hasPublicationYear "2008" @default.
- W1965467335 type Work @default.
- W1965467335 sameAs 1965467335 @default.
- W1965467335 citedByCount "285" @default.
- W1965467335 countsByYear W19654673352012 @default.