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- W1965467384 abstract "Abstract Whether, during iron uptake by rabbit reticulocytes, transferrin-iron molecules penetrate the membrane to the cell interior before release of iron has been investigated. Uptake of 125 I-labelled transferrin and 59 Fe by the stroma and cytoplasm fractions from reticulocyte haemolysates does not suggest that the protein accompanies iron into the cell. The greater part (75%) of the 125 I-labelled transferrin remain on the membrane while iron concentration in the cytoplasm fraction increased linearly with time during incubation. The 25% of 125 I-labelled transferrin in the supernatant may have been derived from contaminated lighter membrane fragments, since approximately the same proportion of membrane fragments as shown by acetylcholinesterase activity was found in the supernatant. When 59 Fe-labelled transferrin-Sepharose was incubated with reticulocytes and cells and then lyzed, 59 Fe activity in the supernatant increased with the time and increasing reticulocyte count; yet not trace of 125 I-labelled transferrin appeared in this fraction when reticulocytes were incubated with 125 I-labelled transferrin-Sepharose. Due to the size of Sepharose (particle size, 40–90 μm) and its covalent binding to transferrin, it is unlikely that transferrin-Sepharose could have penetrated deeply into the cell either by endocytosis or microtubular mechanisms. Our results suggest that transferrin molecules do not need to penetrate the membrane and reach the cell interior before releasing iron." @default.
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- W1965467384 date "1977-11-01" @default.
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- W1965467384 title "Transferrin and iron uptake by rabbit reticulocytes" @default.
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- W1965467384 doi "https://doi.org/10.1016/0005-2736(77)90399-6" @default.
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