FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965467407> ?p ?o ?g. }

• W1965467407 endingPage "693" @default.
• W1965467407 startingPage "683" @default.
• W1965467407 abstract "In the present work we investigated the in vitro effect of 3-hydroxy-3-methylglutarate (HMG) that accumulates in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (HMGLD) on important parameters of oxidative stress in rat cerebral cortex. It was observed that HMG induced lipid peroxidation by significantly increasing chemiluminescence and levels of thiobarbituric acid-reactive substances (TBA-RS). This effect was prevented by the antioxidants alpha-tocopherol, melatonin, N-acetylcysteine, and superoxide dismutase plus catalase, suggesting that free radicals were involved in the lipid oxidative damage. On the other hand, HMG did not change TBA-RS levels in intact or disrupted mitochondrial preparations, indicating that generation of oxidants by this organic acid was dependent on cytosolic mechanisms. HMG also induced protein oxidative damage in cortical supernatants, which was reflected by increased carbonyl content and sulfhydryl oxidation. Furthermore, HMG significantly reduced the nonenzymatic antioxidant defenses total-radical trapping antioxidant potential, total antioxidant reactivity, and reduced glutathione (GSH) levels in rat cerebral cortex. HMG-induced GSH reduction was totally blocked by melatonin pretreatment. We also verified that the decrease of GSH levels provoked by HMG in cortical supernatants was not due to a direct oxidative effect of this organic acid, because exposition of commercial GSH and purified membrane protein-bound thiol groups to HMG in the absence of cortical supernatants did not decrease the reduced sulfhydryl groups. Finally, the activities of the main antioxidant enzymes were not altered by HMG exposure. Our data indicate that oxidative stress elicited in vitro by HMG may possibly contribute at least in part to the pathophysiology of the brain injury in HMGLD." @default.
• W1965467407 created "2016-06-24" @default.
• W1965467407 creator A5002235189 @default.
• W1965467407 creator A5002304573 @default.
• W1965467407 creator A5011992351 @default.
• W1965467407 creator A5019553500 @default.
• W1965467407 creator A5021393597 @default.
• W1965467407 creator A5026628044 @default.
• W1965467407 creator A5035551134 @default.
• W1965467407 creator A5043892833 @default.
• W1965467407 creator A5049059767 @default.
• W1965467407 creator A5077703563 @default.
• W1965467407 creator A5086724940 @default.
• W1965467407 date "2008-01-01" @default.
• W1965467407 modified "2023-10-15" @default.
• W1965467407 title "Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex" @default.
• W1965467407 cites W1122013619 @default.
• W1965467407 cites W1225974061 @default.
• W1965467407 cites W1504816243 @default.
• W1965467407 cites W1544860636 @default.
• W1965467407 cites W1587210733 @default.
• W1965467407 cites W171355676 @default.
• W1965467407 cites W1775749144 @default.
• W1965467407 cites W183120241 @default.
• W1965467407 cites W191793640 @default.
• W1965467407 cites W1971060562 @default.
• W1965467407 cites W1973017657 @default.
• W1965467407 cites W1973193064 @default.
• W1965467407 cites W1979319186 @default.
• W1965467407 cites W1982116658 @default.
• W1965467407 cites W1989386559 @default.
• W1965467407 cites W1990242872 @default.
• W1965467407 cites W1996175319 @default.
• W1965467407 cites W1999518906 @default.
• W1965467407 cites W1999909021 @default.
• W1965467407 cites W2000074333 @default.
• W1965467407 cites W2001387453 @default.
• W1965467407 cites W2003845849 @default.
• W1965467407 cites W2020709143 @default.
• W1965467407 cites W2027499519 @default.
• W1965467407 cites W2031057169 @default.
• W1965467407 cites W2033900283 @default.
• W1965467407 cites W2037657088 @default.
• W1965467407 cites W2038460919 @default.
• W1965467407 cites W2040632746 @default.
• W1965467407 cites W2052023078 @default.
• W1965467407 cites W2066607752 @default.
• W1965467407 cites W2068739860 @default.
• W1965467407 cites W2070235240 @default.
• W1965467407 cites W2071392805 @default.
• W1965467407 cites W2074021937 @default.
• W1965467407 cites W2081874641 @default.
• W1965467407 cites W2103134692 @default.
• W1965467407 cites W2120601805 @default.
• W1965467407 cites W2132534755 @default.
• W1965467407 cites W2143582994 @default.
• W1965467407 cites W2157059809 @default.
• W1965467407 cites W2237282796 @default.
• W1965467407 cites W255295199 @default.
• W1965467407 cites W969915667 @default.
• W1965467407 doi "https://doi.org/10.1002/jnr.21527" @default.
• W1965467407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17941049" @default.
• W1965467407 hasPublicationYear "2008" @default.
• W1965467407 type Work @default.
• W1965467407 sameAs 1965467407 @default.
• W1965467407 citedByCount "32" @default.
• W1965467407 countsByYear W19654674072013 @default.
• W1965467407 countsByYear W19654674072014 @default.
• W1965467407 countsByYear W19654674072015 @default.
• W1965467407 countsByYear W19654674072016 @default.
• W1965467407 countsByYear W19654674072017 @default.
• W1965467407 countsByYear W19654674072018 @default.
• W1965467407 countsByYear W19654674072019 @default.
• W1965467407 countsByYear W19654674072020 @default.
• W1965467407 countsByYear W19654674072021 @default.
• W1965467407 countsByYear W19654674072022 @default.
• W1965467407 crossrefType "journal-article" @default.
• W1965467407 hasAuthorship W1965467407A5002235189 @default.
• W1965467407 hasAuthorship W1965467407A5002304573 @default.
• W1965467407 hasAuthorship W1965467407A5011992351 @default.
• W1965467407 hasAuthorship W1965467407A5019553500 @default.
• W1965467407 hasAuthorship W1965467407A5021393597 @default.
• W1965467407 hasAuthorship W1965467407A5026628044 @default.
• W1965467407 hasAuthorship W1965467407A5035551134 @default.
• W1965467407 hasAuthorship W1965467407A5043892833 @default.
• W1965467407 hasAuthorship W1965467407A5049059767 @default.
• W1965467407 hasAuthorship W1965467407A5077703563 @default.
• W1965467407 hasAuthorship W1965467407A5086724940 @default.
• W1965467407 hasConcept C134018914 @default.
• W1965467407 hasConcept C181199279 @default.
• W1965467407 hasConcept C185592680 @default.
• W1965467407 hasConcept C2775838275 @default.
• W1965467407 hasConcept C2776151105 @default.
• W1965467407 hasConcept C2778004101 @default.
• W1965467407 hasConcept C2778182776 @default.
• W1965467407 hasConcept C2778979269 @default.
• W1965467407 hasConcept C2780829032 @default.
• W1965467407 hasConcept C2781041448 @default.

• next