FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965467422> ?p ?o ?g. }

• W1965467422 endingPage "699" @default.
• W1965467422 startingPage "682" @default.
• W1965467422 abstract "Cellular mechanisms generating the polarized redistribution of maternal Type I postplasmic/PEM mRNAs in ascidian oocytes remain unknown. We have previously shown that PEM-1 mRNA is associated with a network of rough cortical Endoplasmic Reticulum (cER) polarized along the animal-vegetal (a-v) axis forming a cER-mRNA domain in mature oocytes. We now investigate the a-v polarization of this cER-mRNA domain during meiotic maturation using H. roretzi and C. intestinalis. We show that the cER and Hr-PEM-1 aggregate as interconnected cortical patches at the cell periphery before maturation, which uniformly spread out during maturation and form a reticulated organization enriched in the vegetal hemisphere at the end of maturation. Time-lapse video recordings coupled with micromanipulations reveal that stereotyped surface, cortical and cytoplasmic flows accompany the vegetal shift of the cER-mRNA domain and mitochondria-rich myoplasm. Treatments with cytochalasin B and nocodazole indicate that both polarization of the cER-mRNA domain and mitochondria-rich myoplasm and cortical and cytoplasmic flows depend on actin cytoskeleton, but not microtubules. Using cortical fragments prepared from maturing oocytes coupled with high resolution immuno/in situ localization, we have further analyzed the effects of these inhibitors on the reorganizations the cER network and Hr-PEM-1 mRNA. We show that before maturation starts, Hr-PEM-1 mRNAs are already associated with the cER, and actin cytoskeleton inhibitors disturb their association. Finally, we hypothesize that Germinal Vesicle Break Down (GVBD) triggers an actomyosin-dependent cortical flow which directs the a-v polarization of ascidian oocytes." @default.
• W1965467422 created "2016-06-24" @default.
• W1965467422 creator A5033802691 @default.
• W1965467422 creator A5079546587 @default.
• W1965467422 creator A5089696914 @default.
• W1965467422 date "2008-01-01" @default.
• W1965467422 modified "2023-09-26" @default.
• W1965467422 title "Cortical and cytoplasmic flows driven by actin microfilaments polarize the cortical ER-mRNA domain along the a–v axis in ascidian oocytes" @default.
• W1965467422 cites W1485940177 @default.
• W1965467422 cites W1590331881 @default.
• W1965467422 cites W1874891845 @default.
• W1965467422 cites W1931124483 @default.
• W1965467422 cites W1967796034 @default.
• W1965467422 cites W1969839166 @default.
• W1965467422 cites W1970016468 @default.
• W1965467422 cites W1983722060 @default.
• W1965467422 cites W1988405773 @default.
• W1965467422 cites W1988787228 @default.
• W1965467422 cites W1999129204 @default.
• W1965467422 cites W1999327797 @default.
• W1965467422 cites W2000021023 @default.
• W1965467422 cites W2002656407 @default.
• W1965467422 cites W2006200936 @default.
• W1965467422 cites W2010286953 @default.
• W1965467422 cites W2010932551 @default.
• W1965467422 cites W2016657704 @default.
• W1965467422 cites W2034073944 @default.
• W1965467422 cites W2036932956 @default.
• W1965467422 cites W2040811742 @default.
• W1965467422 cites W2042128989 @default.
• W1965467422 cites W2045787804 @default.
• W1965467422 cites W2049537615 @default.
• W1965467422 cites W2052744662 @default.
• W1965467422 cites W2052896280 @default.
• W1965467422 cites W2061043532 @default.
• W1965467422 cites W2061425302 @default.
• W1965467422 cites W2064658390 @default.
• W1965467422 cites W2066059272 @default.
• W1965467422 cites W2066422187 @default.
• W1965467422 cites W2066574156 @default.
• W1965467422 cites W2068065491 @default.
• W1965467422 cites W2068224181 @default.
• W1965467422 cites W2068234279 @default.
• W1965467422 cites W2068421472 @default.
• W1965467422 cites W2075274380 @default.
• W1965467422 cites W2080280371 @default.
• W1965467422 cites W2084167911 @default.
• W1965467422 cites W2085304902 @default.
• W1965467422 cites W2089021149 @default.
• W1965467422 cites W2089394002 @default.
• W1965467422 cites W2090615337 @default.
• W1965467422 cites W2091173681 @default.
• W1965467422 cites W2095247369 @default.
• W1965467422 cites W2098305300 @default.
• W1965467422 cites W2099957469 @default.
• W1965467422 cites W2101031857 @default.
• W1965467422 cites W2102021185 @default.
• W1965467422 cites W2106425485 @default.
• W1965467422 cites W2114056852 @default.
• W1965467422 cites W2114281959 @default.
• W1965467422 cites W2120942749 @default.
• W1965467422 cites W2124073775 @default.
• W1965467422 cites W2130024110 @default.
• W1965467422 cites W2134274895 @default.
• W1965467422 cites W2142698995 @default.
• W1965467422 cites W2153393929 @default.
• W1965467422 cites W2157067397 @default.
• W1965467422 cites W2158865499 @default.
• W1965467422 cites W2163196273 @default.
• W1965467422 cites W2166254523 @default.
• W1965467422 cites W2172257350 @default.
• W1965467422 cites W2183285801 @default.
• W1965467422 cites W2372682635 @default.
• W1965467422 cites W2413655421 @default.
• W1965467422 doi "https://doi.org/10.1016/j.ydbio.2007.11.001" @default.
• W1965467422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18062956" @default.
• W1965467422 hasPublicationYear "2008" @default.
• W1965467422 type Work @default.
• W1965467422 sameAs 1965467422 @default.
• W1965467422 citedByCount "36" @default.
• W1965467422 countsByYear W19654674222012 @default.
• W1965467422 countsByYear W19654674222013 @default.
• W1965467422 countsByYear W19654674222014 @default.
• W1965467422 countsByYear W19654674222015 @default.
• W1965467422 countsByYear W19654674222017 @default.
• W1965467422 countsByYear W19654674222018 @default.
• W1965467422 countsByYear W19654674222019 @default.
• W1965467422 countsByYear W19654674222020 @default.
• W1965467422 countsByYear W19654674222021 @default.
• W1965467422 countsByYear W19654674222022 @default.
• W1965467422 countsByYear W19654674222023 @default.
• W1965467422 crossrefType "journal-article" @default.
• W1965467422 hasAuthorship W1965467422A5033802691 @default.
• W1965467422 hasAuthorship W1965467422A5079546587 @default.
• W1965467422 hasAuthorship W1965467422A5089696914 @default.
• W1965467422 hasBestOaLocation W19654674221 @default.
• W1965467422 hasConcept C104317684 @default.
• W1965467422 hasConcept C105580179 @default.

• next