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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965469087> ?p ?o ?g. }

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• W1965469087 startingPage "2287" @default.
• W1965469087 abstract "Evidence is emerging that changes in the structural and mechanical properties of viral particles are closely linked and that such changes are essential to infectivity. Here, applying the nanostructural and nanomechanical approach of atomic force microscopy, we visualised capsids of the ubiquitous human pathogen herpes simplex virus type 1 (HSV-1) at nano-scale resolution in physiologically relevant conditions. Simultaneously performed nano-indentation measurements on genome-containing and genome-free capsids revealed that genome-containing HSV-1 capsids withstand an exceptionally large mechanical force of ∼6 nN, which is three times larger than the highest values previously reported for other viruses. Greater mechanical forces, however, led to a release of the viral genome. The resulting genome-free capsids, which largely retained their overall structure, were found to be utterly elastic. HSV-1 capsids thus exhibit an exceptional structural and mechanical stability, which is largely provided by the densely packaged genome. This stability might be the key determinant for capsid survival over long distances in the axonal cytoplasm where it is exposed to mechanical forces by molecular motors before it reaches the nuclear pore for crucial genome uncoating." @default.
• W1965469087 created "2016-06-24" @default.
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• W1965469087 date "2008-07-15" @default.
• W1965469087 modified "2023-10-03" @default.
• W1965469087 title "Exceptional mechanical and structural stability of HSV-1 unveiled with fluid atomic force microscopy" @default.
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• W1965469087 doi "https://doi.org/10.1242/jcs.032284" @default.
• W1965469087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18559888" @default.
• W1965469087 hasPublicationYear "2008" @default.
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