Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965476670> ?p ?o ?g. }
- W1965476670 endingPage "9" @default.
- W1965476670 startingPage "1" @default.
- W1965476670 abstract "Loss of the tumor suppressor protein merlin causes a variety of benign tumors such as schwannomas, meningiomas, and gliomas in man. We previously reported primary human schwannoma cells to show enhanced integrin-dependent adhesion and a hyperactivation of the small RhoGTPase Rac1. Here we show that the main intermediate filament protein of Schwann cells, the glial fibrillary acidic protein, is collapsed to the perinuclear region instead of being well-spread from the nucleus to the cell periphery. This cytoskeletal reorganization is accompanied by changes in cell shape and increased cell motility. Moreover, we report tyrosine phosphorylation to be enhanced in schwannoma cells, already described earlier in intermediate filament breakdown. Thus, we believe that Rac activation via tyrosine kinase stimulation leads to GFAP collapse in human schwannoma cells, and suggest that this process plays an important role in vivo where schwannoma cells become motile, unspecifically ensheathing extracellular matrix and forming pseudomesaxons." @default.
- W1965476670 created "2016-06-24" @default.
- W1965476670 creator A5031356003 @default.
- W1965476670 creator A5036615142 @default.
- W1965476670 creator A5045353364 @default.
- W1965476670 date "2005-06-01" @default.
- W1965476670 modified "2023-09-27" @default.
- W1965476670 title "Rearrangements of the intermediate filament GFAP in primary human schwannoma cells" @default.
- W1965476670 cites W1486018977 @default.
- W1965476670 cites W1755868117 @default.
- W1965476670 cites W1913069793 @default.
- W1965476670 cites W1914409163 @default.
- W1965476670 cites W1990537424 @default.
- W1965476670 cites W1990580277 @default.
- W1965476670 cites W1999088634 @default.
- W1965476670 cites W2002123658 @default.
- W1965476670 cites W2015900168 @default.
- W1965476670 cites W2021029937 @default.
- W1965476670 cites W2022031496 @default.
- W1965476670 cites W2027810531 @default.
- W1965476670 cites W2029976610 @default.
- W1965476670 cites W2033097516 @default.
- W1965476670 cites W2033789599 @default.
- W1965476670 cites W2052748706 @default.
- W1965476670 cites W2057209737 @default.
- W1965476670 cites W2058223738 @default.
- W1965476670 cites W2060655307 @default.
- W1965476670 cites W2077080652 @default.
- W1965476670 cites W2081504673 @default.
- W1965476670 cites W2086242462 @default.
- W1965476670 cites W2100868490 @default.
- W1965476670 cites W2102655738 @default.
- W1965476670 cites W2106989193 @default.
- W1965476670 cites W2117429550 @default.
- W1965476670 cites W2119297613 @default.
- W1965476670 cites W2122412289 @default.
- W1965476670 cites W2126048177 @default.
- W1965476670 cites W2133928928 @default.
- W1965476670 cites W2141287268 @default.
- W1965476670 cites W2169954069 @default.
- W1965476670 cites W2171635900 @default.
- W1965476670 cites W2330005549 @default.
- W1965476670 cites W4239941686 @default.
- W1965476670 cites W4294216491 @default.
- W1965476670 doi "https://doi.org/10.1016/j.nbd.2004.11.015" @default.
- W1965476670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15837555" @default.
- W1965476670 hasPublicationYear "2005" @default.
- W1965476670 type Work @default.
- W1965476670 sameAs 1965476670 @default.
- W1965476670 citedByCount "19" @default.
- W1965476670 countsByYear W19654766702013 @default.
- W1965476670 countsByYear W19654766702018 @default.
- W1965476670 crossrefType "journal-article" @default.
- W1965476670 hasAuthorship W1965476670A5031356003 @default.
- W1965476670 hasAuthorship W1965476670A5036615142 @default.
- W1965476670 hasAuthorship W1965476670A5045353364 @default.
- W1965476670 hasConcept C11960822 @default.
- W1965476670 hasConcept C142669718 @default.
- W1965476670 hasConcept C142724271 @default.
- W1965476670 hasConcept C1491633281 @default.
- W1965476670 hasConcept C151166631 @default.
- W1965476670 hasConcept C189165786 @default.
- W1965476670 hasConcept C203014093 @default.
- W1965476670 hasConcept C204232928 @default.
- W1965476670 hasConcept C2776165026 @default.
- W1965476670 hasConcept C2777004073 @default.
- W1965476670 hasConcept C2780495277 @default.
- W1965476670 hasConcept C2781447767 @default.
- W1965476670 hasConcept C502942594 @default.
- W1965476670 hasConcept C55493867 @default.
- W1965476670 hasConcept C58207958 @default.
- W1965476670 hasConcept C71924100 @default.
- W1965476670 hasConcept C78383274 @default.
- W1965476670 hasConcept C86803240 @default.
- W1965476670 hasConcept C95444343 @default.
- W1965476670 hasConceptScore W1965476670C11960822 @default.
- W1965476670 hasConceptScore W1965476670C142669718 @default.
- W1965476670 hasConceptScore W1965476670C142724271 @default.
- W1965476670 hasConceptScore W1965476670C1491633281 @default.
- W1965476670 hasConceptScore W1965476670C151166631 @default.
- W1965476670 hasConceptScore W1965476670C189165786 @default.
- W1965476670 hasConceptScore W1965476670C203014093 @default.
- W1965476670 hasConceptScore W1965476670C204232928 @default.
- W1965476670 hasConceptScore W1965476670C2776165026 @default.
- W1965476670 hasConceptScore W1965476670C2777004073 @default.
- W1965476670 hasConceptScore W1965476670C2780495277 @default.
- W1965476670 hasConceptScore W1965476670C2781447767 @default.
- W1965476670 hasConceptScore W1965476670C502942594 @default.
- W1965476670 hasConceptScore W1965476670C55493867 @default.
- W1965476670 hasConceptScore W1965476670C58207958 @default.
- W1965476670 hasConceptScore W1965476670C71924100 @default.
- W1965476670 hasConceptScore W1965476670C78383274 @default.
- W1965476670 hasConceptScore W1965476670C86803240 @default.
- W1965476670 hasConceptScore W1965476670C95444343 @default.
- W1965476670 hasIssue "1-2" @default.
- W1965476670 hasLocation W19654766701 @default.
- W1965476670 hasLocation W19654766702 @default.
- W1965476670 hasOpenAccess W1965476670 @default.