FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965500084> ?p ?o ?g. }

• W1965500084 endingPage "e119" @default.
• W1965500084 startingPage "e115" @default.
• W1965500084 abstract "Alzheimer's disease (AD) is a complex human neurodegenerative disease. Currently the therapeutics for AD only treats the symptoms. While numbers of excellent studies have used mammalian models to discover new compounds, the time and effort involved with screening large numbers of candidates is prohibitive. Cultured mammalian neurons are often used to perform high-throughput screens (HTS); however, cell culture lacks the organismal complexity involved in AD. To address these issues several researchers are turning to the roundworm, Caenorhabditis elegans. C. elegans has numerous models of both Tau and Aβ induced toxicity, the two prime components observed to correlate with AD pathology. These models have led to the discovery of numerous AD modulating candidates. Further, the ease of performing RNA interference for any gene in the C. elegans genome allows for identification of proteins involved in the mechanism of drug action. These attributes make C. elegans well positioned to aid in the discovery of new AD therapies." @default.
• W1965500084 created "2016-06-24" @default.
• W1965500084 creator A5050614625 @default.
• W1965500084 creator A5066662630 @default.
• W1965500084 date "2013-03-01" @default.
• W1965500084 modified "2023-10-15" @default.
• W1965500084 title "Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity" @default.
• W1965500084 cites W1504674761 @default.
• W1965500084 cites W1573558157 @default.
• W1965500084 cites W1599486403 @default.
• W1965500084 cites W1944127002 @default.
• W1965500084 cites W1947804549 @default.
• W1965500084 cites W1964959041 @default.
• W1965500084 cites W1971275150 @default.
• W1965500084 cites W1974323467 @default.
• W1965500084 cites W1975595547 @default.
• W1965500084 cites W1980825524 @default.
• W1965500084 cites W1992869587 @default.
• W1965500084 cites W1997680903 @default.
• W1965500084 cites W1998941123 @default.
• W1965500084 cites W2000706612 @default.
• W1965500084 cites W2018290089 @default.
• W1965500084 cites W2027773647 @default.
• W1965500084 cites W2031231661 @default.
• W1965500084 cites W2032208441 @default.
• W1965500084 cites W2038976773 @default.
• W1965500084 cites W2050553218 @default.
• W1965500084 cites W2051573801 @default.
• W1965500084 cites W2051629075 @default.
• W1965500084 cites W2061120469 @default.
• W1965500084 cites W2073358143 @default.
• W1965500084 cites W2092545090 @default.
• W1965500084 cites W2103147849 @default.
• W1965500084 cites W2105987904 @default.
• W1965500084 cites W2109502717 @default.
• W1965500084 cites W2131449630 @default.
• W1965500084 cites W2140836066 @default.
• W1965500084 cites W2145138002 @default.
• W1965500084 cites W2146688490 @default.
• W1965500084 cites W2157359173 @default.
• W1965500084 cites W2165021720 @default.
• W1965500084 doi "https://doi.org/10.1016/j.ddtec.2012.02.002" @default.
• W1965500084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640579" @default.
• W1965500084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24050239" @default.
• W1965500084 hasPublicationYear "2013" @default.
• W1965500084 type Work @default.
• W1965500084 sameAs 1965500084 @default.
• W1965500084 citedByCount "96" @default.
• W1965500084 countsByYear W19655000842013 @default.
• W1965500084 countsByYear W19655000842014 @default.
• W1965500084 countsByYear W19655000842015 @default.
• W1965500084 countsByYear W19655000842016 @default.
• W1965500084 countsByYear W19655000842017 @default.
• W1965500084 countsByYear W19655000842018 @default.
• W1965500084 countsByYear W19655000842019 @default.
• W1965500084 countsByYear W19655000842020 @default.
• W1965500084 countsByYear W19655000842021 @default.
• W1965500084 countsByYear W19655000842022 @default.
• W1965500084 countsByYear W19655000842023 @default.
• W1965500084 crossrefType "journal-article" @default.
• W1965500084 hasAuthorship W1965500084A5050614625 @default.
• W1965500084 hasAuthorship W1965500084A5066662630 @default.
• W1965500084 hasBestOaLocation W19655000842 @default.
• W1965500084 hasConcept C104317684 @default.
• W1965500084 hasConcept C111472728 @default.
• W1965500084 hasConcept C138885662 @default.
• W1965500084 hasConcept C142724271 @default.
• W1965500084 hasConcept C166703698 @default.
• W1965500084 hasConcept C169760540 @default.
• W1965500084 hasConcept C19843653 @default.
• W1965500084 hasConcept C207001950 @default.
• W1965500084 hasConcept C2776925932 @default.
• W1965500084 hasConcept C2778944004 @default.
• W1965500084 hasConcept C2779134260 @default.
• W1965500084 hasConcept C51323132 @default.
• W1965500084 hasConcept C54355233 @default.
• W1965500084 hasConcept C60644358 @default.
• W1965500084 hasConcept C67705224 @default.
• W1965500084 hasConcept C70721500 @default.
• W1965500084 hasConcept C71924100 @default.
• W1965500084 hasConcept C74187038 @default.
• W1965500084 hasConcept C86803240 @default.
• W1965500084 hasConcept C89611455 @default.
• W1965500084 hasConceptScore W1965500084C104317684 @default.
• W1965500084 hasConceptScore W1965500084C111472728 @default.
• W1965500084 hasConceptScore W1965500084C138885662 @default.
• W1965500084 hasConceptScore W1965500084C142724271 @default.
• W1965500084 hasConceptScore W1965500084C166703698 @default.
• W1965500084 hasConceptScore W1965500084C169760540 @default.
• W1965500084 hasConceptScore W1965500084C19843653 @default.
• W1965500084 hasConceptScore W1965500084C207001950 @default.
• W1965500084 hasConceptScore W1965500084C2776925932 @default.
• W1965500084 hasConceptScore W1965500084C2778944004 @default.
• W1965500084 hasConceptScore W1965500084C2779134260 @default.
• W1965500084 hasConceptScore W1965500084C51323132 @default.
• W1965500084 hasConceptScore W1965500084C54355233 @default.
• W1965500084 hasConceptScore W1965500084C60644358 @default.
• W1965500084 hasConceptScore W1965500084C67705224 @default.

• next