Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965503024> ?p ?o ?g. }
- W1965503024 abstract "The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These receptors sense danger signals including damage-associated molecular patterns and pathogen-associated molecular patterns (DAMPS and PAMPS respectively). The best-characterized inflammasome is the NLRP3 inflammasome. On assembly of the NLRP3 inflammasome, post-translational processing and secretion of pro-inflammatory cytokines IL-1β and IL-18 occurs; in addition, cell death may be mediated via caspase-1. Intrinsic renal cells express components of the inflammasome pathway. This is most prominent in tubular epithelial cells and, to a lesser degree, in glomeruli. Several primary renal diseases and systemic diseases affecting the kidney are associated with NLRP3 inflammasome/IL-1β/IL-18 axis activation. Most of the disorders studied have been acute inflammatory diseases. The disease spectrum includes ureteric obstruction, ischaemia reperfusion injury, glomerulonephritis, sepsis, hypoxia, glycerol-induced renal failure, and crystal nephropathy. In addition to mediating renal disease, the IL-1/ IL-18 axis may also be responsible for development of CKD itself and its related complications, including vascular calcification and sepsis. Experimental models using genetic deletions and/or receptor antagonists/antiserum against the NLRP3 inflammasome pathway have shown decreased severity of disease. As such, the inflammasome is an attractive potential therapeutic target in a variety of renal diseases." @default.
- W1965503024 created "2016-06-24" @default.
- W1965503024 creator A5031062920 @default.
- W1965503024 creator A5054026641 @default.
- W1965503024 creator A5059544439 @default.
- W1965503024 creator A5080219500 @default.
- W1965503024 creator A5086478476 @default.
- W1965503024 date "2014-01-23" @default.
- W1965503024 modified "2023-10-14" @default.
- W1965503024 title "Is the inflammasome a potential therapeutic target in renal disease?" @default.
- W1965503024 cites W136692196 @default.
- W1965503024 cites W1539959617 @default.
- W1965503024 cites W1546177623 @default.
- W1965503024 cites W1560649513 @default.
- W1965503024 cites W1743744546 @default.
- W1965503024 cites W1756750202 @default.
- W1965503024 cites W1824528611 @default.
- W1965503024 cites W1838328739 @default.
- W1965503024 cites W1891826181 @default.
- W1965503024 cites W1894575361 @default.
- W1965503024 cites W1914666406 @default.
- W1965503024 cites W1954011194 @default.
- W1965503024 cites W1968265929 @default.
- W1965503024 cites W1970303743 @default.
- W1965503024 cites W1971133541 @default.
- W1965503024 cites W1973171955 @default.
- W1965503024 cites W1977884267 @default.
- W1965503024 cites W1978808773 @default.
- W1965503024 cites W1983523234 @default.
- W1965503024 cites W1984520240 @default.
- W1965503024 cites W1987148928 @default.
- W1965503024 cites W1988197452 @default.
- W1965503024 cites W1990079488 @default.
- W1965503024 cites W1991385627 @default.
- W1965503024 cites W1992789370 @default.
- W1965503024 cites W1992815676 @default.
- W1965503024 cites W1995194119 @default.
- W1965503024 cites W1995622771 @default.
- W1965503024 cites W2000779551 @default.
- W1965503024 cites W2002226578 @default.
- W1965503024 cites W2002387125 @default.
- W1965503024 cites W2008945784 @default.
- W1965503024 cites W2009004909 @default.
- W1965503024 cites W2010675399 @default.
- W1965503024 cites W2012453223 @default.
- W1965503024 cites W2012640720 @default.
- W1965503024 cites W2014011959 @default.
- W1965503024 cites W2014955407 @default.
- W1965503024 cites W2017077979 @default.
- W1965503024 cites W2018758055 @default.
- W1965503024 cites W2020675784 @default.
- W1965503024 cites W2023297037 @default.
- W1965503024 cites W2024503063 @default.
- W1965503024 cites W2026075546 @default.
- W1965503024 cites W2026161448 @default.
- W1965503024 cites W2027344074 @default.
- W1965503024 cites W2028225309 @default.
- W1965503024 cites W2028606370 @default.
- W1965503024 cites W2029203960 @default.
- W1965503024 cites W2029442240 @default.
- W1965503024 cites W2032661113 @default.
- W1965503024 cites W2035000995 @default.
- W1965503024 cites W2038370680 @default.
- W1965503024 cites W2044445066 @default.
- W1965503024 cites W2044819348 @default.
- W1965503024 cites W2046319977 @default.
- W1965503024 cites W2048048075 @default.
- W1965503024 cites W2048782984 @default.
- W1965503024 cites W2049000251 @default.
- W1965503024 cites W2050549183 @default.
- W1965503024 cites W2050662655 @default.
- W1965503024 cites W2051658957 @default.
- W1965503024 cites W2052874989 @default.
- W1965503024 cites W2054671245 @default.
- W1965503024 cites W2057442850 @default.
- W1965503024 cites W2057618757 @default.
- W1965503024 cites W2058114190 @default.
- W1965503024 cites W2059381041 @default.
- W1965503024 cites W2062346175 @default.
- W1965503024 cites W2063686879 @default.
- W1965503024 cites W2064282763 @default.
- W1965503024 cites W2066849914 @default.
- W1965503024 cites W2069271543 @default.
- W1965503024 cites W2070734764 @default.
- W1965503024 cites W2072172789 @default.
- W1965503024 cites W2074213282 @default.
- W1965503024 cites W2076063079 @default.
- W1965503024 cites W2080535870 @default.
- W1965503024 cites W2080718655 @default.
- W1965503024 cites W2082067229 @default.
- W1965503024 cites W2083358312 @default.
- W1965503024 cites W2084230276 @default.
- W1965503024 cites W2084363831 @default.
- W1965503024 cites W2090745853 @default.
- W1965503024 cites W2092606519 @default.
- W1965503024 cites W2093580810 @default.
- W1965503024 cites W2094014555 @default.
- W1965503024 cites W2097677296 @default.
- W1965503024 cites W2098444146 @default.
- W1965503024 cites W2098854209 @default.