FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965505536> ?p ?o ?g. }

• W1965505536 endingPage "303" @default.
• W1965505536 startingPage "296" @default.
• W1965505536 abstract "To evaluate photodynamic therapy (PDT) using 5-ALA-induced protoporphyrin IX (PPIX) in an in vivo hypoxic tumor model and its monitoring using MRI. Dunning R3327-AT2 tumors were grafted in the neck of Copenhagen rats. PDT using 150 mg 5-ALA/kg i.v. was performed by focal interstitial illumination of the photosensitized tumor (λ = 633 nm; fluence = 100 J/cm2). MRI at baseline and 2 days after treatment (T1, T2 and dynamic gadolinium enhanced sequences) were performed. Necrosis volumes were determined on post-procedure MRI. Tumors were resected 2 days post-PDT and obtained necrosis was determined histopathologically. Intra-tumoral PPIX distribution was evaluated using confocal microscopy and tissue porphyrin quantification. Twenty rats were treated divided into three groups: continuous (n = 7), fractionated illumination (n = 7), and a control group receiving only light or only ALA or neither (n = 6). Baseline MRI confirmed the hypoxic character of tumors. Necrosis volumes determined on posttreatment MRI were not reproducible and presented with important geometric and volumetric variability. Average necrosis volumes of 0.39 cc (0–0.874 cc) in the continuous group, 0.24 cc (0.107–0.436 cc) in the fractionated group and 0.012 cc (0–0.071 cc) in the control group were observed. Intra-tumoral PPIX distribution was heterogeneous and PPIX quantification revealed low intra-tumoral concentration. Necrosis volumes induced by 5-ALA-mediated PDT were highly variable and non reproducible, probably because of lack of intra-tissular oxygen. Photosensitizer was poorly represented inside the tumor and its distribution was heterogeneous. Our study suggests that 5-ALA-mediated PDT might not be the best management option for hypoxic prostatic adenocarcinoma." @default.
• W1965505536 created "2016-06-24" @default.
• W1965505536 creator A5003106799 @default.
• W1965505536 creator A5006791141 @default.
• W1965505536 creator A5019546842 @default.
• W1965505536 creator A5032190909 @default.
• W1965505536 creator A5049580074 @default.
• W1965505536 creator A5058330133 @default.
• W1965505536 creator A5061342616 @default.
• W1965505536 creator A5078340959 @default.
• W1965505536 creator A5078478531 @default.
• W1965505536 date "2013-09-01" @default.
• W1965505536 modified "2023-10-03" @default.
• W1965505536 title "Efficiency of 5-ALA mediated photodynamic therapy on hypoxic prostate cancer: A preclinical study on the Dunning R3327-AT2 rat tumor model" @default.
• W1965505536 cites W1605545829 @default.
• W1965505536 cites W1954519930 @default.
• W1965505536 cites W1971995358 @default.
• W1965505536 cites W1977861537 @default.
• W1965505536 cites W1991964551 @default.
• W1965505536 cites W1995287452 @default.
• W1965505536 cites W2012002134 @default.
• W1965505536 cites W2012390829 @default.
• W1965505536 cites W2040795610 @default.
• W1965505536 cites W2044760476 @default.
• W1965505536 cites W2049584508 @default.
• W1965505536 cites W2056839504 @default.
• W1965505536 cites W2061259677 @default.
• W1965505536 cites W2062305425 @default.
• W1965505536 cites W2074960820 @default.
• W1965505536 cites W2076754230 @default.
• W1965505536 cites W2081190733 @default.
• W1965505536 cites W2089989509 @default.
• W1965505536 cites W2094300507 @default.
• W1965505536 cites W2133871729 @default.
• W1965505536 cites W2143962930 @default.
• W1965505536 cites W2146641970 @default.
• W1965505536 cites W2151734986 @default.
• W1965505536 cites W2156132669 @default.
• W1965505536 cites W2157255230 @default.
• W1965505536 cites W2167521129 @default.
• W1965505536 cites W2172183230 @default.
• W1965505536 cites W2973926374 @default.
• W1965505536 doi "https://doi.org/10.1016/j.pdpdt.2013.01.003" @default.
• W1965505536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23993856" @default.
• W1965505536 hasPublicationYear "2013" @default.
• W1965505536 type Work @default.
• W1965505536 sameAs 1965505536 @default.
• W1965505536 citedByCount "18" @default.
• W1965505536 countsByYear W19655055362014 @default.
• W1965505536 countsByYear W19655055362015 @default.
• W1965505536 countsByYear W19655055362016 @default.
• W1965505536 countsByYear W19655055362017 @default.
• W1965505536 countsByYear W19655055362018 @default.
• W1965505536 countsByYear W19655055362020 @default.
• W1965505536 countsByYear W19655055362021 @default.
• W1965505536 countsByYear W19655055362023 @default.
• W1965505536 crossrefType "journal-article" @default.
• W1965505536 hasAuthorship W1965505536A5003106799 @default.
• W1965505536 hasAuthorship W1965505536A5006791141 @default.
• W1965505536 hasAuthorship W1965505536A5019546842 @default.
• W1965505536 hasAuthorship W1965505536A5032190909 @default.
• W1965505536 hasAuthorship W1965505536A5049580074 @default.
• W1965505536 hasAuthorship W1965505536A5058330133 @default.
• W1965505536 hasAuthorship W1965505536A5061342616 @default.
• W1965505536 hasAuthorship W1965505536A5078340959 @default.
• W1965505536 hasAuthorship W1965505536A5078478531 @default.
• W1965505536 hasConcept C110121322 @default.
• W1965505536 hasConcept C126838900 @default.
• W1965505536 hasConcept C134306372 @default.
• W1965505536 hasConcept C142724271 @default.
• W1965505536 hasConcept C143409427 @default.
• W1965505536 hasConcept C150903083 @default.
• W1965505536 hasConcept C178790620 @default.
• W1965505536 hasConcept C185592680 @default.
• W1965505536 hasConcept C207001950 @default.
• W1965505536 hasConcept C2779671804 @default.
• W1965505536 hasConcept C2781323092 @default.
• W1965505536 hasConcept C2781469039 @default.
• W1965505536 hasConcept C2989005 @default.
• W1965505536 hasConcept C33923547 @default.
• W1965505536 hasConcept C503630168 @default.
• W1965505536 hasConcept C71924100 @default.
• W1965505536 hasConcept C86803240 @default.
• W1965505536 hasConceptScore W1965505536C110121322 @default.
• W1965505536 hasConceptScore W1965505536C126838900 @default.
• W1965505536 hasConceptScore W1965505536C134306372 @default.
• W1965505536 hasConceptScore W1965505536C142724271 @default.
• W1965505536 hasConceptScore W1965505536C143409427 @default.
• W1965505536 hasConceptScore W1965505536C150903083 @default.
• W1965505536 hasConceptScore W1965505536C178790620 @default.
• W1965505536 hasConceptScore W1965505536C185592680 @default.
• W1965505536 hasConceptScore W1965505536C207001950 @default.
• W1965505536 hasConceptScore W1965505536C2779671804 @default.
• W1965505536 hasConceptScore W1965505536C2781323092 @default.
• W1965505536 hasConceptScore W1965505536C2781469039 @default.
• W1965505536 hasConceptScore W1965505536C2989005 @default.
• W1965505536 hasConceptScore W1965505536C33923547 @default.
• W1965505536 hasConceptScore W1965505536C503630168 @default.

• next