FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965508723> ?p ?o ?g. }

• W1965508723 endingPage "e76762" @default.
• W1965508723 startingPage "e76762" @default.
• W1965508723 abstract "The appearance of donor-derived lymphocytes in liver transplant patients suggests that adult livers may contain cells capable of lymphopoiesis. However, only a few published studies have addressed the lymphopoietic capacity of adult liver cells, and its kinetics and features remain unclear. Herein, we investigated the lymphopoietic capacity of adult liver mononuclear cells (MNCs) and purified liver hematopoietic progenitor cells (HPCs) in vivo. Similar to bone-marrow transplantation (BMT), transplantation of liver MNCs alone was able to rescue survival of lethally irradiated mice. In terms of kinetics, liver MNC-derived myeloid lineage cells reconstituted more slowly than those from BMT. Liver MNC-derived lymphocyte lineage cells in the blood, spleen and BM also reconstituted more slowly than BMT, but lymphocytes in the liver recovered at a similar rate. Interestingly, liver MNCs predominantly gave rise to CD3+CD19− T cells in both irradiated WT and non-irradiated lymphocyte-deficient Rag-1−/−Il2rg−/− recipients. To define the lymphopoietic potential of various cell populations within liver MNCs, we transplanted purified lineage-negative (Lin−) liver HPCs into recipient mice. Unlike total liver MNCs, liver HPCs reconstituted T and B cells in similar frequencies to BMT. We further determined that the predominance of T cells observed after transplanting total liver MNCs likely originated from mature T cells, as purified donor liver T cells proliferated in the recipients and gave rise to CD8+ T cells. Thus, the capacity of donor adult liver cells to reconstitute lymphocytes in recipients derives from both HPCs and mature T cells contained in the liver MNC population." @default.
• W1965508723 created "2016-06-24" @default.
• W1965508723 creator A5012198733 @default.
• W1965508723 creator A5041353057 @default.
• W1965508723 creator A5083130438 @default.
• W1965508723 creator A5086549736 @default.
• W1965508723 creator A5087062633 @default.
• W1965508723 date "2013-10-09" @default.
• W1965508723 modified "2023-09-26" @default.
• W1965508723 title "Characterizing the Lymphopoietic Kinetics and Features of Hematopoietic Progenitors Contained in the Adult Murine Liver In Vivo" @default.
• W1965508723 cites W1929834221 @default.
• W1965508723 cites W1937332911 @default.
• W1965508723 cites W1974520072 @default.
• W1965508723 cites W1994729912 @default.
• W1965508723 cites W1998566378 @default.
• W1965508723 cites W2010876644 @default.
• W1965508723 cites W2021672266 @default.
• W1965508723 cites W2028081773 @default.
• W1965508723 cites W2029180341 @default.
• W1965508723 cites W2030338295 @default.
• W1965508723 cites W2042982622 @default.
• W1965508723 cites W2048161767 @default.
• W1965508723 cites W2049781837 @default.
• W1965508723 cites W2067556396 @default.
• W1965508723 cites W2081536518 @default.
• W1965508723 cites W2085907177 @default.
• W1965508723 cites W2095166272 @default.
• W1965508723 cites W2101380121 @default.
• W1965508723 cites W2115864156 @default.
• W1965508723 cites W2118097954 @default.
• W1965508723 cites W2125334139 @default.
• W1965508723 cites W2154699417 @default.
• W1965508723 cites W2158242992 @default.
• W1965508723 cites W2163168560 @default.
• W1965508723 cites W2336171903 @default.
• W1965508723 cites W4249724591 @default.
• W1965508723 doi "https://doi.org/10.1371/journal.pone.0076762" @default.
• W1965508723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3793923" @default.
• W1965508723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24130788" @default.
• W1965508723 hasPublicationYear "2013" @default.
• W1965508723 type Work @default.
• W1965508723 sameAs 1965508723 @default.
• W1965508723 citedByCount "5" @default.
• W1965508723 countsByYear W19655087232016 @default.
• W1965508723 countsByYear W19655087232019 @default.
• W1965508723 countsByYear W19655087232021 @default.
• W1965508723 crossrefType "journal-article" @default.
• W1965508723 hasAuthorship W1965508723A5012198733 @default.
• W1965508723 hasAuthorship W1965508723A5041353057 @default.
• W1965508723 hasAuthorship W1965508723A5083130438 @default.
• W1965508723 hasAuthorship W1965508723A5086549736 @default.
• W1965508723 hasAuthorship W1965508723A5087062633 @default.
• W1965508723 hasBestOaLocation W19655087231 @default.
• W1965508723 hasConcept C109159458 @default.
• W1965508723 hasConcept C126322002 @default.
• W1965508723 hasConcept C201750760 @default.
• W1965508723 hasConcept C203014093 @default.
• W1965508723 hasConcept C2779282312 @default.
• W1965508723 hasConcept C2780007613 @default.
• W1965508723 hasConcept C2780931953 @default.
• W1965508723 hasConcept C28328180 @default.
• W1965508723 hasConcept C2908647359 @default.
• W1965508723 hasConcept C2911091166 @default.
• W1965508723 hasConcept C71924100 @default.
• W1965508723 hasConcept C79904392 @default.
• W1965508723 hasConcept C86803240 @default.
• W1965508723 hasConcept C95444343 @default.
• W1965508723 hasConcept C99454951 @default.
• W1965508723 hasConceptScore W1965508723C109159458 @default.
• W1965508723 hasConceptScore W1965508723C126322002 @default.
• W1965508723 hasConceptScore W1965508723C201750760 @default.
• W1965508723 hasConceptScore W1965508723C203014093 @default.
• W1965508723 hasConceptScore W1965508723C2779282312 @default.
• W1965508723 hasConceptScore W1965508723C2780007613 @default.
• W1965508723 hasConceptScore W1965508723C2780931953 @default.
• W1965508723 hasConceptScore W1965508723C28328180 @default.
• W1965508723 hasConceptScore W1965508723C2908647359 @default.
• W1965508723 hasConceptScore W1965508723C2911091166 @default.
• W1965508723 hasConceptScore W1965508723C71924100 @default.
• W1965508723 hasConceptScore W1965508723C79904392 @default.
• W1965508723 hasConceptScore W1965508723C86803240 @default.
• W1965508723 hasConceptScore W1965508723C95444343 @default.
• W1965508723 hasConceptScore W1965508723C99454951 @default.
• W1965508723 hasIssue "10" @default.
• W1965508723 hasLocation W19655087231 @default.
• W1965508723 hasLocation W19655087232 @default.
• W1965508723 hasLocation W19655087233 @default.
• W1965508723 hasLocation W19655087234 @default.
• W1965508723 hasLocation W19655087235 @default.
• W1965508723 hasOpenAccess W1965508723 @default.
• W1965508723 hasPrimaryLocation W19655087231 @default.
• W1965508723 hasRelatedWork W2008579876 @default.
• W1965508723 hasRelatedWork W2074196969 @default.
• W1965508723 hasRelatedWork W2314522894 @default.
• W1965508723 hasRelatedWork W2405181172 @default.
• W1965508723 hasRelatedWork W2410746613 @default.
• W1965508723 hasRelatedWork W2412102303 @default.
• W1965508723 hasRelatedWork W2413214566 @default.

• next