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- W1965512560 endingPage "489" @default.
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- W1965512560 abstract "Somatic hypermutation (SHM) requires selective targeting of the mutational machinery to the variable region of the immunoglobulin heavy chain gene. The induction of SHM in the BL2 cell line upon costimulation is associated with hyperacetylation of the chromatin at the variable region but not at the constant region. The V region-restricted histone hyperacetylation resulting from costimulation occurs independent of AID expression and mutation. Interestingly, costimulation in the presence of Trichostatin A causes hyperacetylation of histones associated with the constant region and extends mutations to the constant region. Under this condition, promoter proximal mutations are observed in the variable region as well. The overexpression of AID results in a similar deregulation of mutational targeting. Our results indicate that the stimulation of SHM in BL2 cells activates two independent pathways resulting in histone modifications that permit induced levels of AID to selectively target the variable region for mutation." @default.
- W1965512560 created "2016-06-24" @default.
- W1965512560 creator A5024371287 @default.
- W1965512560 creator A5053213338 @default.
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- W1965512560 date "2003-10-01" @default.
- W1965512560 modified "2023-10-16" @default.
- W1965512560 title "Induction of Somatic Hypermutation Is Associated with Modifications in Immunoglobulin Variable Region Chromatin" @default.
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- W1965512560 doi "https://doi.org/10.1016/s1074-7613(03)00261-9" @default.
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