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- W1965514223 endingPage "159" @default.
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- W1965514223 abstract "The endoplasmic reticulum (ER) is a multifunctional organelle which co-ordinates protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins, ER stress and up-regulation of a signaling pathway called the ER stress response or the unfolded protein response (UPR). The UPR is characterized by the induction of chaperones, degradation of misfolded proteins and attenuation of protein translation. Age-related declines and activity in key molecular chaperones and folding enzymes compromise proper protein folding and the adaptive response of the UPR. This review will highlight age-related changes in the protein folding machinery and in the UPR." @default.
- W1965514223 created "2016-06-24" @default.
- W1965514223 creator A5088766184 @default.
- W1965514223 date "2009-07-01" @default.
- W1965514223 modified "2023-09-27" @default.
- W1965514223 title "ER and aging—Protein folding and the ER stress response" @default.
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- W1965514223 doi "https://doi.org/10.1016/j.arr.2009.03.001" @default.
- W1965514223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19491040" @default.
- W1965514223 hasPublicationYear "2009" @default.
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