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- W196552199 abstract "Osteoblastic cell differentiation and proliferation are multistep processes involving numerous growth factors and signaling molecules in a regulated manner that is highly complex and not yet fully understood. Osteogenic Protein-1 (0P-1), a member of the bone morphogenetic protein (BMP) subfamily of the transforming growth factor-β3 (TGF-β) superfamily (1–5), induces new bone formation in vivo (6,7). In different osteoblastic cell cultures, including fetal rat calvaria (FRC) cells and human osteosarcoma cell lines, the recombinant human OP-1 stimulates synthesis of various biochemical markers characteristic of osteoblastic cell differentiation in a defined spatial and temporal manner (6,8–12). OP-1 also stimulates synthesis of other growth factors, such as insulin-like growth factor (IGF)-I (13–15). Knowledge of the functional relationship between OP-1 and these growth factors will not only further our understanding of the mechanism of the inductive action of OP-1 but also the osteoblastic cell differentiation." @default.
- W196552199 created "2016-06-24" @default.
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- W196552199 date "2004-01-01" @default.
- W196552199 modified "2023-09-27" @default.
- W196552199 title "Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation" @default.
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- W196552199 doi "https://doi.org/10.1007/978-1-59259-736-9_12" @default.
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