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• W1965530701 abstract "Podosomes are dynamic actin-enriched membrane structures that play an important role in invasive cell motility and extracellular matrix degradation. They are often found to assemble into large rosettelike structures in highly invasive cells. However, the mechanism of this assembly remains obscure. In this study, we identified focal adhesion kinase (FAK) as a key molecule necessary for assembly. Moreover, phosphorylation of p130Cas and suppression of Rho signaling by FAK were found to be important for FAK to induce the assembly of podosome rosettes. Finally, we found that suppression of vimentin intermediate filaments by FAK facilitates the assembly of podosome rosettes. Collectively, our results strongly suggest a link between FAK, podosome rosettes, and tumor invasion and unveil a negative role for Rho signaling and vimentin filaments in podosome rosette assembly." @default.
• W1965530701 created "2016-06-24" @default.
• W1965530701 creator A5016185746 @default.
• W1965530701 creator A5055541466 @default.
• W1965530701 creator A5082443098 @default.
• W1965530701 date "2011-10-03" @default.
• W1965530701 modified "2023-09-26" @default.
• W1965530701 title "FAK is required for the assembly of podosome rosettes" @default.
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• W1965530701 doi "https://doi.org/10.1083/jcb.201103016" @default.
• W1965530701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3187704" @default.
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• W1965530701 hasPublicationYear "2011" @default.
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