FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965531137> ?p ?o ?g. }

• W1965531137 endingPage "284" @default.
• W1965531137 startingPage "277" @default.
• W1965531137 abstract "The advantages Drosophila has to offer for studies on the induction of mutations and chromosome aberrations are in anifold. The wealth of specific tester strains, special markers, useful inversions, or other rearrangements makes it possible to test in one and the same experiment for the total spectrum of genetic changes ranging from dominant lethals and chromosome loss (as indication for non-restituted breaks) to translocations (misrepaired breaks), recessive lethals, deletions, crossing-over, nondisjunction, complete and mosaic visible mutations in a whole array of different germ cell stages. Moreover, a detailed genetic analysis of each of these is possible and thus may shed light on mechanisms and consequences of induction of the genetic changes involved. Studies on the ability of agents to produce both gene mutations and chromosome aberrations are particularly important when evaluating the relevance of current testing procedures for environmental mutagens in mammalian systems that are based on chromosome reakage effects. Thus, hycanthone, diethyl nitrosamine and diethyl sulphate that all produce recessive sex-linked lethals at high frequency in Drosophila, but no chromosome breakage, would erroneously register as safe in most mammalian test systems. New methods for the detection of autosomal non-disjunction have recently been worked out, and deficiencies which are expected to arise with a much higher frequency after chemical treatment than with X-rays, can be easily discovered by employing simple recessive lethal tests. One piece of recent evidence that strengthens the premise of the suitability of Drosophila for studies in chemical mutagenesis, is that in tests of “indirect mutagens” the flies appear to carry out the same activating transformations as those occurring in the mammalian liver. Furthermore, exact methods for chemical dosimetry are available. In addition to all other advantages, Drosophila certainly offers the quickest test system for mutations available in animals today. Consequently, it may provide guidance on the kind of questions that should be looked for in more laborious systems. Thus, observations on modifications and specificities in Drosophila, show at least that a particular treatment can be modified, and this may then be followed up in mammalian cells." @default.
• W1965531137 created "2016-06-24" @default.
• W1965531137 creator A5087905819 @default.
• W1965531137 date "1974-08-01" @default.
• W1965531137 modified "2023-09-28" @default.
• W1965531137 title "The advantages of drosophila for mutation studies" @default.
• W1965531137 cites W1547855195 @default.
• W1965531137 cites W1552585298 @default.
• W1965531137 cites W173571385 @default.
• W1965531137 cites W1964530403 @default.
• W1965531137 cites W1968998942 @default.
• W1965531137 cites W1972306590 @default.
• W1965531137 cites W1973140861 @default.
• W1965531137 cites W1975182655 @default.
• W1965531137 cites W1980064678 @default.
• W1965531137 cites W1983253167 @default.
• W1965531137 cites W1987923762 @default.
• W1965531137 cites W2017618578 @default.
• W1965531137 cites W2017995673 @default.
• W1965531137 cites W2018485131 @default.
• W1965531137 cites W2018828561 @default.
• W1965531137 cites W2023024605 @default.
• W1965531137 cites W2028738321 @default.
• W1965531137 cites W2037223648 @default.
• W1965531137 cites W2040391523 @default.
• W1965531137 cites W2054907346 @default.
• W1965531137 cites W2057875452 @default.
• W1965531137 cites W2060711085 @default.
• W1965531137 cites W2061535219 @default.
• W1965531137 cites W2073276461 @default.
• W1965531137 cites W2085962246 @default.
• W1965531137 cites W2127185728 @default.
• W1965531137 cites W2217368533 @default.
• W1965531137 cites W2407435165 @default.
• W1965531137 cites W2419108090 @default.
• W1965531137 cites W2460761244 @default.
• W1965531137 cites W2500454155 @default.
• W1965531137 cites W264438476 @default.
• W1965531137 cites W3139970425 @default.
• W1965531137 cites W3177827925 @default.
• W1965531137 cites W343267751 @default.
• W1965531137 cites W57099202 @default.
• W1965531137 doi "https://doi.org/10.1016/s0027-5107(74)80025-4" @default.
• W1965531137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4369264" @default.
• W1965531137 hasPublicationYear "1974" @default.
• W1965531137 type Work @default.
• W1965531137 sameAs 1965531137 @default.
• W1965531137 citedByCount "48" @default.
• W1965531137 countsByYear W19655311372019 @default.
• W1965531137 crossrefType "journal-article" @default.
• W1965531137 hasAuthorship W1965531137A5087905819 @default.
• W1965531137 hasConcept C104317684 @default.
• W1965531137 hasConcept C138626823 @default.
• W1965531137 hasConcept C16318435 @default.
• W1965531137 hasConcept C2776041557 @default.
• W1965531137 hasConcept C2779066155 @default.
• W1965531137 hasConcept C2779672484 @default.
• W1965531137 hasConcept C2780104201 @default.
• W1965531137 hasConcept C30481170 @default.
• W1965531137 hasConcept C501734568 @default.
• W1965531137 hasConcept C54355233 @default.
• W1965531137 hasConcept C86803240 @default.
• W1965531137 hasConceptScore W1965531137C104317684 @default.
• W1965531137 hasConceptScore W1965531137C138626823 @default.
• W1965531137 hasConceptScore W1965531137C16318435 @default.
• W1965531137 hasConceptScore W1965531137C2776041557 @default.
• W1965531137 hasConceptScore W1965531137C2779066155 @default.
• W1965531137 hasConceptScore W1965531137C2779672484 @default.
• W1965531137 hasConceptScore W1965531137C2780104201 @default.
• W1965531137 hasConceptScore W1965531137C30481170 @default.
• W1965531137 hasConceptScore W1965531137C501734568 @default.
• W1965531137 hasConceptScore W1965531137C54355233 @default.
• W1965531137 hasConceptScore W1965531137C86803240 @default.
• W1965531137 hasIssue "4" @default.
• W1965531137 hasLocation W19655311371 @default.
• W1965531137 hasLocation W19655311372 @default.
• W1965531137 hasOpenAccess W1965531137 @default.
• W1965531137 hasPrimaryLocation W19655311371 @default.
• W1965531137 hasRelatedWork W1503756910 @default.
• W1965531137 hasRelatedWork W1590731218 @default.
• W1965531137 hasRelatedWork W1927894038 @default.
• W1965531137 hasRelatedWork W2111061681 @default.
• W1965531137 hasRelatedWork W2121689324 @default.
• W1965531137 hasRelatedWork W2135257384 @default.
• W1965531137 hasRelatedWork W2136886756 @default.
• W1965531137 hasRelatedWork W2406076746 @default.
• W1965531137 hasRelatedWork W2409673575 @default.
• W1965531137 hasRelatedWork W2586867991 @default.
• W1965531137 hasVolume "26" @default.
• W1965531137 isParatext "false" @default.
• W1965531137 isRetracted "false" @default.
• W1965531137 magId "1965531137" @default.
• W1965531137 workType "article" @default.