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- W1965536368 abstract "A68 Aims: In the present study we evaluated the influence of different immunosuppressive regimens on the delayed graft function and the progression of renal function in the 1st year after transplantation. Methods: Patients were divided in 4 groups according to the immunosuppressive regimen received: Group 1.Rapamycin (Rap) + Mycophenolate Mofetil (MMF) + Methylprednisolone (MP) + Daclizumab (Dmab) (n=44) Group 2.Tacrolimus (Tac) + MMF + MP + Dmab (n=39) Group 3. Cyclosporine (CsA) + MMF + MP + Basiliximab (Bmab) (n=30) Group 4.Antithymocyte Globulin (ATG) + MMF + MP and CsA after ATG’s withdrawal (n=40). Delayed graft function was defined as the need for hemodialysis post-transplantation. Data were analysed using ANOVA and linear regression. Results: There was no statistically significant difference between the 4 groups in terms of gender, time on dialysis before transplantation, histocompatibility, donor’ s age and cold-ischemia time. However age (49.8, 50.4, 49.8 and 43.5 years, p<0.05), panel reactive antibodies (22, 39, 27, 34 %, p<0.05) and time of delayed graft function (12, 7, 3, 6 days, p<0.05) were found to be significantly different between the 4 groups. The delayed graft function time was found to depend on the immunosuppressive regimen as well as donor’s and recipient’s age (p<0.05). The creatinine clearance demonstrated statistically significant difference between the 4 groups in the 1st month after transplantation (45, 46, 61, 53 ml/min, p<0.05), though no further difference was observed until the 12th month. Conclusions: The type of immunosuppressive therapy seems to substantially influence the time of recovery from delayed renal graft function, even though it doesn’t seem to affect future graft function. Especially Rapamycin, probably due to its potent antiproliferative effect, prolongs the time of graft recovery after renal transplantation." @default.
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- W1965536368 date "2004-07-01" @default.
- W1965536368 modified "2023-10-17" @default.
- W1965536368 title "DELAYED RENAL GRAFT FUNCTION: THE INFLUENCE OF IMMUNOSUPRESSION" @default.
- W1965536368 doi "https://doi.org/10.1097/00007890-200407271-01795" @default.
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