Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965560657> ?p ?o ?g. }
- W1965560657 endingPage "6367" @default.
- W1965560657 startingPage "6359" @default.
- W1965560657 abstract "Capillary online restricted-access media-liquid chromatography-electrospray ionization-tandem mass spectrometry (RAM-LC-ESI-MS/MS) for direct analysis of drugs and metabolites spiked in biological fluids was developed. Using a column switching setup it was possible to perform effective sample preparation and analysis of raw biological fluids (plasma and urine) without matrix effects in the electrospray mass spectrometric detection step. The peak focusing efficiency of the extraction column was more effective in backflush compared to foreflush mode. The system was able to concentrate diminished samples of polar drugs and their metabolites reaching quantifiable results as low as 1 ng/mL utilizing a sample volume of only 333 nL of biofluids. New column hardware was developed to circumvent clogging problems experienced with plasma injections. The glass fiber filter frit, which is commonly used, was replaced with a short piece of 20 microm i.d. fused silica capillary. The extraction columns were able to handle up to 60 injections and showed a high loading capacity, making the saturation of the MS detector the limiting factor on the linear dynamic range. The simultaneous separation and detection of 10 drugs and metabolites was obtained in 8 min of analysis, including the online sample preparation and enrichment step." @default.
- W1965560657 created "2016-06-24" @default.
- W1965560657 creator A5043604785 @default.
- W1965560657 creator A5058459874 @default.
- W1965560657 creator A5067538945 @default.
- W1965560657 creator A5072680368 @default.
- W1965560657 creator A5087057938 @default.
- W1965560657 date "2007-07-12" @default.
- W1965560657 modified "2023-10-08" @default.
- W1965560657 title "Capillary Column Switching Restricted-Access Media-Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry System for Simultaneous and Direct Analysis of Drugs in Biofluids" @default.
- W1965560657 cites W1967028528 @default.
- W1965560657 cites W1975571245 @default.
- W1965560657 cites W1975890572 @default.
- W1965560657 cites W1977314239 @default.
- W1965560657 cites W1980317106 @default.
- W1965560657 cites W1983757610 @default.
- W1965560657 cites W1990620284 @default.
- W1965560657 cites W1993508830 @default.
- W1965560657 cites W1996262571 @default.
- W1965560657 cites W2007455664 @default.
- W1965560657 cites W2012375346 @default.
- W1965560657 cites W2012495298 @default.
- W1965560657 cites W2016968987 @default.
- W1965560657 cites W2025910897 @default.
- W1965560657 cites W2027832078 @default.
- W1965560657 cites W2034532845 @default.
- W1965560657 cites W2040308794 @default.
- W1965560657 cites W2041575674 @default.
- W1965560657 cites W2049263486 @default.
- W1965560657 cites W2054752451 @default.
- W1965560657 cites W2057406669 @default.
- W1965560657 cites W2066323347 @default.
- W1965560657 cites W2071536080 @default.
- W1965560657 cites W2072683551 @default.
- W1965560657 cites W2073322299 @default.
- W1965560657 cites W2076373920 @default.
- W1965560657 cites W2079050321 @default.
- W1965560657 cites W2079554237 @default.
- W1965560657 cites W2080283413 @default.
- W1965560657 cites W2082662891 @default.
- W1965560657 cites W2085518714 @default.
- W1965560657 cites W2091000397 @default.
- W1965560657 cites W2092416385 @default.
- W1965560657 cites W2093203097 @default.
- W1965560657 cites W2124061340 @default.
- W1965560657 cites W2316461311 @default.
- W1965560657 cites W4230694333 @default.
- W1965560657 cites W4250812778 @default.
- W1965560657 cites W49021375 @default.
- W1965560657 cites W99072460 @default.
- W1965560657 doi "https://doi.org/10.1021/ac070671g" @default.
- W1965560657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17628079" @default.
- W1965560657 hasPublicationYear "2007" @default.
- W1965560657 type Work @default.
- W1965560657 sameAs 1965560657 @default.
- W1965560657 citedByCount "32" @default.
- W1965560657 countsByYear W19655606572012 @default.
- W1965560657 countsByYear W19655606572013 @default.
- W1965560657 countsByYear W19655606572014 @default.
- W1965560657 countsByYear W19655606572015 @default.
- W1965560657 countsByYear W19655606572016 @default.
- W1965560657 countsByYear W19655606572017 @default.
- W1965560657 countsByYear W19655606572020 @default.
- W1965560657 countsByYear W19655606572021 @default.
- W1965560657 countsByYear W19655606572022 @default.
- W1965560657 crossrefType "journal-article" @default.
- W1965560657 hasAuthorship W1965560657A5043604785 @default.
- W1965560657 hasAuthorship W1965560657A5058459874 @default.
- W1965560657 hasAuthorship W1965560657A5067538945 @default.
- W1965560657 hasAuthorship W1965560657A5072680368 @default.
- W1965560657 hasAuthorship W1965560657A5087057938 @default.
- W1965560657 hasConcept C113196181 @default.
- W1965560657 hasConcept C119128265 @default.
- W1965560657 hasConcept C159985019 @default.
- W1965560657 hasConcept C162356407 @default.
- W1965560657 hasConcept C185592680 @default.
- W1965560657 hasConcept C192562407 @default.
- W1965560657 hasConcept C194451485 @default.
- W1965560657 hasConcept C196806460 @default.
- W1965560657 hasConcept C2778576202 @default.
- W1965560657 hasConcept C31827203 @default.
- W1965560657 hasConcept C40684141 @default.
- W1965560657 hasConcept C43617362 @default.
- W1965560657 hasConcept C4725764 @default.
- W1965560657 hasConcept C64489805 @default.
- W1965560657 hasConceptScore W1965560657C113196181 @default.
- W1965560657 hasConceptScore W1965560657C119128265 @default.
- W1965560657 hasConceptScore W1965560657C159985019 @default.
- W1965560657 hasConceptScore W1965560657C162356407 @default.
- W1965560657 hasConceptScore W1965560657C185592680 @default.
- W1965560657 hasConceptScore W1965560657C192562407 @default.
- W1965560657 hasConceptScore W1965560657C194451485 @default.
- W1965560657 hasConceptScore W1965560657C196806460 @default.
- W1965560657 hasConceptScore W1965560657C2778576202 @default.
- W1965560657 hasConceptScore W1965560657C31827203 @default.
- W1965560657 hasConceptScore W1965560657C40684141 @default.
- W1965560657 hasConceptScore W1965560657C43617362 @default.
- W1965560657 hasConceptScore W1965560657C4725764 @default.