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- W1965561454 abstract "To the Editor.— In his editorial, Dr. Chalmers states that positive inotropic effect on the heart... has now been confirmed by catheterization studies in humans, quoting as a source the review by Levey et al ( Ann Rev Med 25:69, 1974). In turn, this review alludes to Hildner et al, who studied 15 patients requiring cardiac catheterization in whom a bolus injection of 250 mg of tolbutamide, given intravenously, produced a definite inotropic effect as reflected by ventricular function curves. In a less convincing technique (noninvasive, using a carotid sensor), they demonstrated a similar effect by measuring preejection period and left ventricular ejection times. I believe Dr. Chalmers should, in fair balance, have included the following additional statements of Levey et al: The critical question pertaining to whether or not sulfonylureas have inotropic actions on human hearts remains unresolved. Epstein and co-workers examined the effects of tolbutamide on two human" @default.
- W1965561454 created "2016-06-24" @default.
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- W1965561454 date "1975-05-26" @default.
- W1965561454 modified "2023-09-27" @default.
- W1965561454 title "The UGDP Scandal and Cover-up" @default.
- W1965561454 doi "https://doi.org/10.1001/jama.1975.03250080010004" @default.
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