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• W1965566672 abstract "Retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) is a pivotal receptor that detects numerous RNA and DNA viruses and mediates the innate induction of interferons and pro-inflammatory cytokines upon viral infection. In the present study, we cloned and characterized the first RIG-I gene in a marine mollusk , Crassostrea gigas , and designated it as CgRIG-I. The full-length CgRIG-I cDNA is 3436 bp, including 5′- and 3′-untranslated regions (UTRs) of 93 bp and 286 bp, respectively, and an open reading frame (ORF) of 3057 bp. The gene encodes a 1018 amino acid polypeptide with an estimated molecular mass of 116.5 kDa. SMART analysis showed that the CgRIG-I protein had the typical conserved domains, including the caspase activation and recruitment domains (CARDs), the RNA helicase domain and the C-terminal regulatory domain (RD). Phylogenetic analysis revealed that CgRIG-I was grouped into the clade of its vertebrate homologs. Moreover, CgRIG-I expression could be specifically increased after stimulation by poly(I:C) rather than by other PAMPs such as lipopolysaccharide (LPS), peptidoglycan (PGN), heat-killed Listeria monocytogenes (HKLM) and heat-killed Vibrio alginolyticus (HKVA). Meanwhile, six IRF , three STAT and one NF-κB predicted sites were identified in the CgRIG-I promoter, which was consistent with its high responsiveness to poly(I:C). In summary, this report provides the first CgRIG-I sequence of a mollusk, but its function in the antiviral immune response requires further investigation. • The full-length CgRIG-I cDNA is 3436 bp including an open reading frame of 3057 bp. • CgRIG-I has an ancient orgin that prior to the appearance of vertebrates. • CgRIG-I expression could be evidently up-regulated by poly(I:C), but not by LPS, PGN, HKLM and HKVA. • The first experimental evidence for presence of RLR in an mollusk." @default.
• W1965566672 created "2016-06-24" @default.
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• W1965566672 date "2014-10-01" @default.
• W1965566672 modified "2023-09-24" @default.
• W1965566672 title "The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas" @default.
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• W1965566672 doi "https://doi.org/10.1016/j.fsi.2014.07.029" @default.
• W1965566672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25107697" @default.
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