FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965574428> ?p ?o ?g. }

• W1965574428 endingPage "3402" @default.
• W1965574428 startingPage "3398" @default.
• W1965574428 abstract "Extensive phase II metabolism of an advanced PKCε inhibitor resulted in sub-optimal pharmacokinetics in rat marked by elevated clearance. Synthesis of the O-glucuronide metabolite as a standard was followed by three distinct strategies to specifically temper phase II metabolic degradation of the parent molecule. In this study, it was determined that the introduction of proximal polarity to the primary alcohol generally curbed O-glucuronidation and improved PK and physical chemical properties while maintaining potency against the target. Utilization of a Jacobsen hydrolytic kinetic resolution to obtain optically enriched final compounds is also discussed." @default.
• W1965574428 created "2016-06-24" @default.
• W1965574428 creator A5004867144 @default.
• W1965574428 creator A5008730381 @default.
• W1965574428 creator A5020852223 @default.
• W1965574428 creator A5025988887 @default.
• W1965574428 creator A5029538767 @default.
• W1965574428 creator A5032006974 @default.
• W1965574428 creator A5034936331 @default.
• W1965574428 creator A5038317636 @default.
• W1965574428 creator A5042363507 @default.
• W1965574428 creator A5046861116 @default.
• W1965574428 creator A5047626436 @default.
• W1965574428 creator A5055417912 @default.
• W1965574428 creator A5056595730 @default.
• W1965574428 creator A5059040410 @default.
• W1965574428 creator A5064278171 @default.
• W1965574428 creator A5065106003 @default.
• W1965574428 creator A5065316038 @default.
• W1965574428 creator A5069492111 @default.
• W1965574428 creator A5070895391 @default.
• W1965574428 creator A5071786624 @default.
• W1965574428 creator A5072063223 @default.
• W1965574428 creator A5079170240 @default.
• W1965574428 creator A5080170794 @default.
• W1965574428 creator A5086019316 @default.
• W1965574428 date "2014-08-01" @default.
• W1965574428 modified "2023-10-14" @default.
• W1965574428 title "Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors" @default.
• W1965574428 cites W1701778517 @default.
• W1965574428 cites W1963591519 @default.
• W1965574428 cites W1974318174 @default.
• W1965574428 cites W1975458358 @default.
• W1965574428 cites W1976307613 @default.
• W1965574428 cites W2010580563 @default.
• W1965574428 cites W2050098038 @default.
• W1965574428 cites W2053608147 @default.
• W1965574428 cites W2064249788 @default.
• W1965574428 cites W2068875447 @default.
• W1965574428 cites W2075212824 @default.
• W1965574428 cites W2110929990 @default.
• W1965574428 cites W2130973111 @default.
• W1965574428 cites W2164215880 @default.
• W1965574428 cites W2169210654 @default.
• W1965574428 cites W2316477829 @default.
• W1965574428 doi "https://doi.org/10.1016/j.bmcl.2014.05.082" @default.
• W1965574428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24939756" @default.
• W1965574428 hasPublicationYear "2014" @default.
• W1965574428 type Work @default.
• W1965574428 sameAs 1965574428 @default.
• W1965574428 citedByCount "6" @default.
• W1965574428 countsByYear W19655744282014 @default.
• W1965574428 countsByYear W19655744282015 @default.
• W1965574428 countsByYear W19655744282019 @default.
• W1965574428 countsByYear W19655744282021 @default.
• W1965574428 crossrefType "journal-article" @default.
• W1965574428 hasAuthorship W1965574428A5004867144 @default.
• W1965574428 hasAuthorship W1965574428A5008730381 @default.
• W1965574428 hasAuthorship W1965574428A5020852223 @default.
• W1965574428 hasAuthorship W1965574428A5025988887 @default.
• W1965574428 hasAuthorship W1965574428A5029538767 @default.
• W1965574428 hasAuthorship W1965574428A5032006974 @default.
• W1965574428 hasAuthorship W1965574428A5034936331 @default.
• W1965574428 hasAuthorship W1965574428A5038317636 @default.
• W1965574428 hasAuthorship W1965574428A5042363507 @default.
• W1965574428 hasAuthorship W1965574428A5046861116 @default.
• W1965574428 hasAuthorship W1965574428A5047626436 @default.
• W1965574428 hasAuthorship W1965574428A5055417912 @default.
• W1965574428 hasAuthorship W1965574428A5056595730 @default.
• W1965574428 hasAuthorship W1965574428A5059040410 @default.
• W1965574428 hasAuthorship W1965574428A5064278171 @default.
• W1965574428 hasAuthorship W1965574428A5065106003 @default.
• W1965574428 hasAuthorship W1965574428A5065316038 @default.
• W1965574428 hasAuthorship W1965574428A5069492111 @default.
• W1965574428 hasAuthorship W1965574428A5070895391 @default.
• W1965574428 hasAuthorship W1965574428A5071786624 @default.
• W1965574428 hasAuthorship W1965574428A5072063223 @default.
• W1965574428 hasAuthorship W1965574428A5079170240 @default.
• W1965574428 hasAuthorship W1965574428A5080170794 @default.
• W1965574428 hasAuthorship W1965574428A5086019316 @default.
• W1965574428 hasConcept C112705442 @default.
• W1965574428 hasConcept C114373084 @default.
• W1965574428 hasConcept C146686406 @default.
• W1965574428 hasConcept C161790260 @default.
• W1965574428 hasConcept C181199279 @default.
• W1965574428 hasConcept C185592680 @default.
• W1965574428 hasConcept C202751555 @default.
• W1965574428 hasConcept C2777477808 @default.
• W1965574428 hasConcept C2779186261 @default.
• W1965574428 hasConcept C2779907587 @default.
• W1965574428 hasConcept C28173026 @default.
• W1965574428 hasConcept C55493867 @default.
• W1965574428 hasConcept C57992300 @default.
• W1965574428 hasConcept C62231903 @default.
• W1965574428 hasConcept C71240020 @default.
• W1965574428 hasConcept C71924100 @default.
• W1965574428 hasConcept C87644729 @default.
• W1965574428 hasConcept C89311334 @default.

• next